DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chb and TOGARAM1

DIOPT Version :9

Sequence 1:	NP_524651.2	Gene:	chb / 43901	FlyBaseID:	FBgn0021760	Length:	1491	Species:	Drosophila melanogaster
Sequence 2:	NP_001295049.1	Gene:	TOGARAM1 / 23116	HGNCID:	19959	Length:	1773	Species:	Homo sapiens

Alignment Length:	1578	Identity:	295/1578 - (18%)
Similarity:	511/1578 - (32%)	Gaps:	515/1578 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GFIQQ------MPKADMRVKVQLAEDLVTFL------SDDTNSIVCTDMGFLIDGLMPWLTGSHF 63
            |.|.|      :.:.|.:.:.|..|:|...|      |...:|:|    || |..|...|..|:|
Human   349 GIIPQELHSRLLDQEDYKNRTQAVEELKQVLGKFNPSSTPHSSLV----GF-ISLLYNLLDDSNF 408

  Fly    64 KIAQKSLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQAL 128
            |:...:||....|:.|||.....:...|:...:..|.|::..::::...:...||: .|.|.|.|
Human   409 KVVHGTLEVLHLLVIRLGEQVQQFLGPVIAASVKVLADNKLVIKQEYMKIFLKLMK-EVGPQQVL 472

  Fly   129 IDKLATSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLV 193
            .  |.....|||:::||||.:...:.:|..|.::...:......:...|.|....||:||::...
Human   473 C--LLLEHLKHKHSRVREEVVNICICSLLTYPSEDFDLPKLSFDLAPALVDSKRRVRQAALEAFA 535

  Fly   194 EIYKHVGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEGLLLPSALKNTNGNGVGLDEADNIGLR 258
            .:...:|              :.|.::|.:..|.|:.:          .||:||         :.
Human   536 VLASSMG--------------SGKTSILFKAVDTVELQ----------DNGDGV---------MN 567

  Fly   259 ERPTRMIKRPLHSAVSSSLRPKPNVNDVTGDAGAVTMESFESSFEVVPQL------NIFHAKDMD 317
            ....|:.::.|         |:            :|.:.|.....::|..      ::.|..|
Human   568 AVQARLARKTL---------PR------------LTEQGFVEYAVLMPSSAGGRSNHLAHGAD-- 609

  Fly   318 DIYKQVLVIISDKNADWEKRVDALKKIRALLILSYHTQPQFVAVQLKELSLSFVDILKEELRSQV 382
                          .||             |:....||
Human   610 --------------TDW-------------LLAGNRTQ--------------------------- 620

  Fly   383 IREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASAS-TIALKYIIKYTHAPKLLKI 446
                               .|.|     |..:.:::|..:..|.| ||..:.::........|..
Human   621 -------------------SAHC-----HCGDHVRDSMHIYGSYSPTICTRRVLSAGKGKNKLPW 661

  Fly   447 YTDT-----LNQ-SKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKS----IGDADCDA 501
            ..:.     .|| |.||||            |::.|.....:|     .||.|    :.|..|.:
Human   662 ENEQPGIMGENQTSTSKDI------------EQFSTYDFIPSA-----KLKLSQGMPVNDDLCFS 709

  Fly   502 R-RHSRYAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGGGGTGTG----TGTAPET--RR 559
            | |.||..:...|...|:       .|.:.|            .|.|||.    :|...:.  .:
Human   710 RKRVSRNLFQNSRDFNPD-------CLPLCA------------AGTTGTHQTNLSGKCAQLGFSQ 755

  Fly   560 TVSRIGRTPGTLQKPTPSMRSISAVDTAAAQRAKVRAQYTLYSRQRKPLGPNNSNQASMTGAAAS 624
            ...:.|.....||          .:.|.::.:.||.|.....|:.::..|    :|...|
Human   756 ICGKTGSVGSDLQ----------FLGTTSSHQEKVYASLNFGSKTQQTFG----SQTECT----- 801

  Fly   625 GSLPRPRLNSNSGGTPATTPGSVTPRPRGRAGVSQSQPGSRSTSPSTKLRDQYGGIGNYYRGATG 689
                     |::|..|  :||         |.:..|.|.|   ||.|.
Human   802 ---------SSNGQNP--SPG---------AYILPSYPVS---SPRTS----------------- 826

  Fly   690 AIPKKASGIPRSTASSRETS-------PTRSGGGLMKRSMYSTGAGSRRTPERNNPVRPSAAARL 747
              ||..|.:..|...|::.|       |.:|..||.|                     ||...:|
Human   827 --PKHTSPLIISPKKSQDNSVNFSNSWPLKSFEGLSK---------------------PSPQKKL 868

  Fly   748 LAQSREAEHTLGVGDDGQ---PDYVSGDYMRSGGMRMGRKLMGRDESDDIDSEASSVCSERSFDS 809
            ::|..........|::.|   |..::...:||...|.|  |.|......|....|.:..:....
Human   869 VSQKSSDPTGRNHGENSQEKPPVQLTPALVRSPSSRRG--LNGTKPVPPIPRGISLLPDKADLS- 930

  Fly   810 SYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQFCASTHWSERKDGL-ISLTQYLADGKELT 873
              |.|:|                ::.| |||           |...||.| |.|::.....|:|.
Human   931 --TVGHK----------------KKEP-DDI-----------WKCEKDSLPIDLSELNFKDKDLD 965

  Fly   874 QQQLKCVLDMFRKMFMDTHTKVYSLFLDTVTELILVHANELHEWLFILLTRLFNKLGTDLLNSMH 938
            |:::...|...|........|:.....|                    |....:.:..||  :|.
Human   966 QEEMHSSLRSLRNSAAKKRAKLSGSTSD--------------------LESPDSAMKLDL--TMD 1008

  Fly   939 SKIWKTLQVVHEYFPTQLQLKELFRIISDSTQTPTTKTRIAILRFLTDLANTYCKSSDFPSDQSQ 1003
            |....:...::.|..:.:..:|  .:.|..:.||..|      |.::|:         ||:..|:
Human  1009 SPSLSSSPNINSYSESGVYSQE--SLTSSLSTTPQGK------RIMSDI---------FPTFGSK 1056

  Fly  1004 ACERTVLKLAQLAADQKSMELRSQARSCLVALYNLNTPQMTLLLADLPKVYQDSARSCIHSHMRR 1068
            .|.      .:|::.:|.:                                         ||:..
Human  1057 PCP------TRLSSAKKKI-----------------------------------------SHIAE 1074

  Fly  1069 QSQSCNSGANSPSSSPLSSSSPKPLQSPSV-----GPFASLQSHHHQLSISSTSPRSRQSSVEQE 1128
            ||.|..|.:|....|....::.|.|...||     |.|.||.      |..:|..:|..||||..
Human  1075 QSPSAGSSSNPQQISSFDFTTTKALSEDSVVVVGKGVFGSLS------SAPATCSQSVISSVENG 1133

  Fly  1129 LLFSSELDIQHNIQKTSEEIRHCFGGQYQTALAPNGFNGHLQYHDQGQQDSCASLSSNSKTQSSA 1193
            ..||    |:.:|:..|        |.|..::..| .:.:|..  :.::|:..|:|     :|:.
Human  1134 DTFS----IKQSIEPPS--------GIYGRSVQQN-ISSYLDV--ENEKDAKVSIS-----KSTY 1178

  Fly  1194 NTTQSNTPESATM---------------RLDNLERERTTQNAKSPTDDAKVITVSI-NMAENGEL 1242
            |..:....|...:               |:.:...|:....:::||.........: ::..:.|:
Human  1179 NKMRQKRKEEKELFHNKDCEKKEKNSWERMRHTGTEKMASESETPTGAISQYKERMPSVTHSPEI 1243

  Fly  1243 ILASNLMESEVVRVALT----LTKDQPVELLQTSLTNLGICIKGGNCELPNKHFR----SIMRML 1299
            :..|.|.......:|||    |..|:..|.....| |...|:...:.|:.|....    ::::.:
Human  1244 MDLSELRPFSKPEIALTEALRLLADEDWEKKIEGL-NFIRCLAAFHSEILNTKLHETNFAVVQEV 1307

  Fly  1300 LNILEAEHTDVVIAGLHVLSKIMRSNKMRHNWMHFLELILLKIIQCYQHSKEALR-DID----SM 1359
            .|:........|:....:.:.:.:|....      |:..:..::.....|...:| |:|    :|
Human  1308 KNLRSGVSRAAVVCLSDLFTYLKKSMDQE------LDTTVKVLLHKAGESNTFIREDVDKALRAM 1366

  Fly  1360 IPRIAPSLPLDLSINIVNPVIATGEFPTNLCAIKILLEVTEHHGSE-ITDAHLDI---VFPNLAR 1420
            :..:.|:..:   ::::|...:........|..:.|.:|.|....| |..|..|:   :.|..|:
Human  1367 VNNVTPARAV---VSLINGGQSHLHIAVRRCTAQHLSDVLEFMEPERILSAAKDMAERILPAAAK 1428

  Fly  1421 SADD----TQSMVRKAAVFCIVKLYFVLGEEKVKP-------KLSVLNPSKVRLLNVYIE----K 1470
            .|.|    |:...||...|.:....|....||..|       |.||.|..:..|..:.::    |
Human  1429 FAQDSSQETRYYGRKMLFFMMCHPNFEKMLEKYVPSKDLPYIKDSVRNLQQKGLGEIPLDTPSAK 1493

  Fly  1471 QRNCISGGGSSTKNSSAA 1488
            .|...:|...:|::||.:
Human  1494 GRRSHTGSVGNTRSSSVS 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787	9/27 (33%)
		CLASP_N	<74..211	CDD:289144	30/136 (22%)
		HEAT repeat	90..120	CDD:293787	5/29 (17%)
		HEAT_2	129..>210	CDD:290374	17/80 (21%)
		HEAT repeat	131..154	CDD:293787	8/22 (36%)
		HEAT repeat	165..195	CDD:293787	6/29 (21%)
		CLASP_N	316..536	CDD:289144	37/231 (16%)
TOGARAM1	NP_001295049.1	HEAT repeat	395..423	CDD:293787	10/28 (36%)
		HEAT repeat	435..465	CDD:293787	5/30 (17%)
		HEAT repeat	470..501	CDD:293787	11/32 (34%)
		HEAT repeat	512..537	CDD:293787	6/24 (25%)
		LRIF1	<811..1152	CDD:292369	103/529 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158166
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930