DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chb and cls-3

DIOPT Version :9

Sequence 1:	NP_524651.2	Gene:	chb / 43901	FlyBaseID:	FBgn0021760	Length:	1491	Species:	Drosophila melanogaster
Sequence 2:	NP_001379049.1	Gene:	cls-3 / 176298	WormBaseID:	WBGene00013847	Length:	983	Species:	Caenorhabditis elegans

Alignment Length:	1246	Identity:	253/1246 - (20%)
Similarity:	485/1246 - (38%)	Gaps:	320/1246 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 VSSSLRPKPNVNDVTGDAGAVTMESFESSFEVVPQLNIFHAKDMDDIYKQVLVIISDKNADWEKR 337
            ::|.::||..|.       :|:...|...||.||::.|..|.|:.:.:..|.:|:|:.:.||.||
Worm     1 MTSRMQPKSGVY-------SVSKADFTKIFEDVPKVPITSAVDLRNKFDAVRIILSNSSEDWNKR 58

  Fly   338 VDALKKIRALLILSYH-----TQPQFVA--VQLKELSLSFVDILKEELRSQVIREACITIAYMSK 395
            ...||.:|:|:|   |     .:|..:|  |||    |...::..::|||||:|||.||.:::..
Worm    59 QTQLKTVRSLVI---HGEKVVDRPTMIAHLVQL----LGCFELAVKDLRSQVLREAAITCSFIVS 116

  Fly   396 TLRNKLDAFCWSILEHLINLIQNSAKVIASASTIALKYIIKYTHAPKLLKIYTDTLNQSKSKDIR 460
            ....:..:....||...::.:..|.|::|::::...::|::|....::..|.: :.:.||.|..|
Worm   117 KYGIETHSIGEDILVPAMSQVAVSTKIMATSASTLTEFIVEYVQTRQVFTILS-SFSTSKDKSQR 180

  Fly   461 STLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDADCDARRHSRYAYWAFRRHFPELADQIYG 525
            ..|..|:.::..:|..:..::....:.:.:|.:|.|||.:.|...|.|:........|.||.:|.
Worm   181 RQLAALLEIVISKWSDRIKKQIMRQICELIKSAINDADSETRAAGRRAFAKLDEMHSEEADALYL 245

  Fly   526 TLDIAAQRALEREREGGGGGGTGTGTGTAPETRRTVSRIGRTPGTLQKPTPSMRSISAVDTAAAQ 590
            .||.:.|:.|.............:..|:.| .|..:|...:....:.....:.||.||:|..|.:
Worm   246 ELDHSKQKMLRGGDAASSWASVNSEKGSIP-IRSKLSAGSKAHMNISAKFLAQRSASAIDPKATK 309

  Fly   591 RA------KVRAQYTLYSRQRKPLGPNNSNQASM--TGAAASGSLPRPRLNSNSGGTPATTPGSV 647
            .|      :..:..|:..:...|.|...||..||  .....|..:|.|
Worm   310 FAGPSRLVRPTSTKTMARQDTSPAGCKYSNFISMFFKTLLLSAKIPYP----------------- 357

  Fly   648 TPRPRGRAGVSQSQPGSRSTSPSTKLRDQYGGIGNYYRGATGAIPKKASGIPRSTASSRETSPTR 712
                        ::||||:.:.|.                             ::..||:|||||
Worm   358 ------------NRPGSRTRTSSI-----------------------------TSTDSRDTSPTR 381

  Fly   713 SGGGLMKRSMYSTGAGSRRTPERNNPVRPSAAARLLAQSREAEHTLGVGDDGQPDYVSGDYMRSG 777
                                  ||:|:.|        ::::|          :..|.:|.:....
Worm   382 ----------------------RNSPLPP--------ETQKA----------RVKYGNGSFFAKL 406

  Fly   778 GMRMGRKLMGRDESDD--------IDSEASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQR 834
            ||        .|.:||        |.|...:...|                   :|
Worm   407 GM--------PDTTDDDEFLLPIRIRSPLKTPTIE-------------------AH--------- 435

  Fly   835 APFDDIETIIQFCASTHWSERKDGLISLTQYLADGKELTQQQLKCVLDMFRKMFMDTHT----KV 895
               |.:..:::.|.|:..||:|:|:..|...:|| ..|...::|.:.:...::..|...    ::
Worm   436 ---DKVSQVLKECCSSSVSEKKEGIKKLLPIVAD-TSLNPIEIKNIGNCLNRLLSDASNTMVLEI 496

  Fly   896 YSLFLDTVTELILVHANELHEWLFILLTRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKE 960
            ||:|:.|       |::.|.|||.:.|.:||.:...:.|.:...:|..||.|:.|.|....||..
Worm   497 YSIFVRT-------HSSRLSEWLRLALAKLFARKAAETLPNTKKQIGHTLNVILECFNAHHQLVT 554

  Fly   961 LFRIISDSTQTPTTKTRIAILRFLTDLANTYCKSSDFPSDQSQACERTVLKLAQLAADQK-SMEL 1024
            :..::.|.......|.|:.:|.:||.|.:.|.:..  .|..::..:..:.|:...|:|.: |:.|
Worm   555 VCELMCDPIHLMVPKARVVLLEYLTSLLDEYTEPG--ASINAKELKTAIRKMLTWASDPRLSILL 617

  Fly  1025 RSQARSCLVALYNLNTPQMTLLLADLPKVYQDSARSCIHSHMRRQSQSCNSGANSPSSSPLSSSS 1089
            .......:.:::.:|....:.|::||    ....::.||..::|     |...|..||:.::::|
Worm   618 TPHVEKAICSMFCVNVADFSALISDL----DSEQKNWIHQTLQR-----NGLENGISSNNIATNS 673

  Fly  1090 PKPLQSPSVGPFASLQSHHHQLSISSTS---PR--SRQSSVEQELLFSSELDIQHNIQKTSEEIR 1149
                     |..||.::.:......|||   |.  :|:......|   ..|:|.:|:..:..|
Worm   674 ---------GATASRETSNTSFQKESTSFGLPEFGARKGGTGVNL---GSLNISNNLALSRLE-- 724

  Fly  1150 HCFGGQYQTALAPNGFNGHLQYHDQGQQDSCASLSSNSKTQSSANTTQSNTPESATMRLDNLERE 1214
                                       :.|.:.|.......|:. |...:|.|......|.|::.
Worm   725 ---------------------------EQSTSRLMEKVNLNSTV-TLPPDTLEKIQNVQDLLQKM 761

  Fly  1215 RTTQNAKSPTDDAKVITVSINMAENG---------ELILASNLMESEVVRVALTLTKDQPVELLQ 1270
            |:::||..  .::.:.::.:.:.:.|         :|:|  ||.|        .|:|.:
Worm   762 RSSENADE--QESAISSIYMMICDGGFGVWEQCYAKLLL--NLFE--------ILSKSR------ 808

  Fly  1271 TSLTNLGICIKGGNCELPNKHFRSIMRMLLNILEAEHTDVVIAGLHVLSKIMRSNKMRHNWMHFL 1335
             |..|..:|                :|:|..:..|:           .:|:..|.
Worm   809 -SENNKKMC----------------LRILGKMCTAQ-----------AAKLFDST---------- 835

  Fly  1336 ELILLKIIQCYQHSKEALR--DIDSMIPRIAPSLPLDLSINIVNPVIATGEFPTN----LCAIKI 1394
            |:.:.|::....::.:|..  .::..:..:|..|||...|||...::  .:.|.:    ...:|:
Worm   836 EMAVCKVLDAAVNTNDATTALAVEDCLRTLATHLPLSNIINIAKVIL--NQEPIDDERASLVLKM 898

  Fly  1395 LLEVTEHHGSEITDAHLDIVFPNLARSADDTQSMVRKAAVFCIVKLYFVLGEEKVKPKLSVLNPS 1459
            :..:.|...:|..:..:|.:.|.:.::...|.|.|||..|:|:|.:...:||:::.|..:.|..:
Worm   899 VTRLFEELPAEELNNIVDDITPTIIKAYQSTSSTVRKTVVYCLVAMVNRVGEQRMTPHFTKLPKA 963

  Fly  1460 KVRLLNVYIEK 1470
            ...|:.||:.:
Worm   964 MTNLIQVYVNR 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787
		CLASP_N	<74..211	CDD:289144
		HEAT repeat	90..120	CDD:293787
		HEAT_2	129..>210	CDD:290374
		HEAT repeat	131..154	CDD:293787
		HEAT repeat	165..195	CDD:293787
		CLASP_N	316..536	CDD:289144	59/226 (26%)
cls-3	NP_001379049.1	CLASP_N	50..255	CDD:403532	56/212 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166750
Domainoid	1	1.000	149	1.000	Domainoid score	I2711
eggNOG	1	0.900	-	-		E1_KOG2956
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I2103
Isobase	1	0.950	-	0	Normalized mean entropy	S7030
OMA	1	1.010	-	-		QHG59940
OrthoDB	1	1.010	-	-		D62708at33208
OrthoFinder	1	1.000	-	-		FOG0001668
OrthoInspector	1	1.000	-	-		otm14073
orthoMCL	1	0.900	-	-		OOG6_102734
Panther	1	1.100	-	-	O	PTHR21567
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1839
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.720