Protein Alignment chb and cls-2

DIOPT Version :9

• Sequence 1: NP_524651.2
• Gene: chb / 43901
• FlyBaseID: FBgn0021760
• Length: 1491
• Species: Drosophila melanogaster
• Sequence 2: NP_001263723.1
• Gene: cls-2 / 176280
• WormBaseID: WBGene00000549
• Length: 1023
• Species: Caenorhabditis elegans
• Alignment Length: 1225
• Identity: 259/1225 - (21%)
• Similarity: 473/1225 - (38%)
• Gaps: 264/1225 - (21%)

  Fly   288 GDAGAVTMESFESSFEVVPQLNIFHAKDMDDIYKQVLVIISDKNADWEKRVDALKKIRALLILSY 352
            |....|:.:.|..|||.||::.|....|..:...|.:..:|....||.||::.||:||::::
 Worm    11 GGTCIVSKDDFLKSFEEVPKMEISSPSDFKEKLDQTIETLSKGQEDWNKRMNKLKQIRSMVV--- 72

  Fly   353 HTQPQFVAVQLKELSLSFVDILK---EELRSQVIREACITIAYMSKTLRNKLDAFCWSILEHLIN 414
            |.:......||....:...|.|.   ::||||::|||.||..::.|.....:.......|.....
 Worm    73 HGEDVIGREQLLSQLVRLTDCLDLSVKDLRSQILREAAITCGFLFKRFGTDVRQIAERCLPSAFA 137

  Fly   415 LIQNSAKVIASASTIALKYIIKYTHAPKLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKAL 479
            .:..|.||:|:...:...:|:::....::..... :.:.||.|:.|..||.|:.::.|.|..|..
 Worm   138 QVAVSTKVMATCGAVLTLFIVEFIQTKQIFTCIA-SYSTSKDKNQRRQLCALLEIVLEHWNEKIK 201

  Fly   480 ERNATVLRDTLKKSIGDADCDARRHSRYAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGG 544
            ......:.:.:|.:|.|||.:.|...|.|:..........||:::.::|.:.|:.|.........
 Worm   202 RTVLPQIGELIKAAICDADPETRVAGRKAFSKLDALHSTEADKLFASVDSSKQKMLRASDAASSS 266

  Fly   545 GGTGTGTGTAP-ETRRTVSRIG--RTPGTLQKPTPSMRSISAVDTAAAQRAKVRAQYTLYSRQRK 606
            ....:..|||| .::.:...||  |....:.....:.||.||:||....|...       |..|.
 Worm   267 TSINSERGTAPFRSKLSAGSIGGIRNAPNISSKFLAQRSASAIDTKQVTRMAT-------SVSRT 324

  Fly   607 PLGPNNSNQASMTGAAASGSLPRPRLNSNSGGTPATTP--GSVTPRP----RGRAGVSQSQPGSR 665
            |      |...||....|      :::::.||:....|  |::..|.    |.|..|..||||||
 Worm   325 P------NIRPMTTRTLS------KIDTSPGGSKFARPTVGALGSRTSSNLRARGSVPTSQPGSR 377

  Fly   666 STSPSTKLRDQYGGIGNYYRGATGAIPKKASGIPRSTASSRETSPTRSGGGLMKRSMYSTGAGSR 730
            :.||
 Worm   378 NGSP------------------------------------------------------------- 381

  Fly   731 RTPERNNPVRPSAAARLLAQSREAEHTLGVGDDGQPDYVSGDYMRSGGMRMGRKLMGRDESDDID 795
                   |.||||.....|:.:..:..||          |..::.|.......||
 Worm   382 -------PRRPSATEAFPAEMQRVKSNLG----------SNSFVSSLSAEEATKL---------- 419

  Fly   796 SEASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQRAPFDD--IETIIQFCASTHWSERKDG 858
            .:|.:...|.....|  |.:...:.|....|....:.|::..|.  :|.:|:.|:||..:|:::|
 Worm   420 QKAMNTAKESLRQPS--RNDDDEFLLPKRPTPQKATPQKSALDTSRVEEVIRACSSTSANEKREG 482

  Fly   859 LISLTQYLADGKELTQQQLKCVLDMFRKMFMDTHTKVYSLFLDTVTELILVHANELHEWLFILLT 923
            :..|...::: ..|:..::|.:..:..::..::..::   .|::::..:..|...|.:||.:.|.
 Worm   483 IKMLAGIVSE-PNLSNAEIKSLGAVLNRLLGESTNQI---VLESISSFVKTHHPRLSDWLKLGLG 543

  Fly   924 RLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFRIISDSTQTPTTKTRIAILRFLTDLA 988
            :||.|.|.::..:...:|..|:..:...|...||||....::.|.....:.|:|:.:|.:|.:|.
 Worm   544 KLFAKKGAEMTLNSKKQISTTISCILSSFDPTLQLKSTCELVCDPIHLMSPKSRVVLLEYLNELL 608

  Fly   989 NTYC-KSSDFPSDQSQACERTVLKLAQLAADQKSMEL-RSQARSCLVALYNLNTPQMTLLLADLP 1051
            ..|. :.|.|.:.:.:|   |:||:....|||::.:| .......|.:|:.||....:.|..|..
 Worm   609 GKYMERGSSFNTKEMKA---TILKMFSWMADQRNEQLITPHGEKVLCSLFALNNADFSALFNDFN 670

  Fly  1052 KVYQDSARSCIHSHMRRQ---------SQSCNSGANSPSSSPLS------SSSPKPLQSPSVGPF 1101
            ..|:|.|...:.||...|         .::|.....|.:::.:.      :....|::|||.
 Worm   671 PDYRDWAYKVLQSHGHDQHVPQQDAVSEEACVRATISTTAAQIEDFVVSRNLDMTPVKSPST--- 732

  Fly  1102 ASLQSHHHQLSISSTSPRSRQSSVEQELL--FSSELDIQHNIQKTSEEIRHCFGGQYQTALAPNG 1164
                     .:|||...|     |:.|.|  .|||::.||..::.|
 Worm   733 ---------RAISSGFKR-----VDAEPLRPLSSEMNSQHRDEELS------------------- 764

  Fly  1165 FNGHLQYHDQGQQDSCASLSSNSKTQSSANTTQSNTPESATMRLDNLERERTTQNAKSPTDDAKV 1229
            ||           :|...|..||.|....:|::                       :|....:|:
 Worm   765 FN-----------ESFDRLKLNSTTHLIDDTSE-----------------------QSKYVASKL 795

  Fly  1230 ITVSINM-AENGELILASNLMESEVVRVALTLTKDQPVELLQTSLTNLGICIKGGNCELPNKHFR 1293
            ..:|.:| |:..|.:|:                       :||.|..       |:..|..::|.
 Worm   796 AQISGDMGAQQYEGLLS-----------------------IQTMLCE-------GSFTLWEQNFA 830

  Fly  1294 SIMRMLLNILEAEHTDV-VIAGLHVLSKIMRSNKMRHNWMHFLELILLKIIQCYQHSKEALRDI- 1356
            .::..:.::|....:|. ....|.||:|:..|...|  .....|:.:.|::....:|::...::
 Worm   831 KLLIAVFDVLSKSESDANKKVALRVLTKMCTSQASR--LFDSTEMAICKVLDAAVNSQDGTMNVT 893

  Fly  1357 -DSMIPRIAPSLPLDLSINIVNPVI-----ATGEFPTNLCAIKILLEVTEHHGSEITDAHLDIVF 1415
             |..:..:|..|||...:||...::     ...:.|.....:|::..:.|...::.....:|.:.
 Worm   894 ADDCLKTLATHLPLAKVVNISQLILNEYLQEKAQEPKASLVLKMMTRLFEGLQADELSPVVDDLA 958

  Fly  1416 PNLARSADDTQSMVRKAAVFCIVKLYFVLGEEKVKPKLSVLNPSKVRLLNVYIEK 1470
            |.:.:|.|...|.|||.||:|:|.:...||.:.::|.|..|:..|:.|:.||:.:
 Worm   959 PCVIKSYDSPSSAVRKTAVYCLVAMVNKLGMKTMEPHLQNLSSGKLNLVQVYVNR 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787
		CLASP_N	<74..211	CDD:289144
		HEAT repeat	90..120	CDD:293787
		HEAT_2	129..>210	CDD:290374
		HEAT repeat	131..154	CDD:293787
		HEAT repeat	165..195	CDD:293787
		CLASP_N	316..536	CDD:289144	53/222 (24%)
cls-2	NP_001263723.1	CLASP_N	56..257	CDD:289144	51/204 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166751
Domainoid	1	1.000	149	1.000	Domainoid score	I2711
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I2103
Isobase	1	0.950	-	0	Normalized mean entropy	S7030
OMA	1	1.010	-	-		QHG59940
OrthoDB	1	1.010	-	-		D62708at33208
OrthoFinder	1	1.000	-	-		FOG0001668
OrthoInspector	1	1.000	-	-		otm14073
orthoMCL	1	0.900	-	-		OOG6_102734
Panther	1	1.100	-	-	LDO	PTHR21567
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2455
SonicParanoid	1	1.000	-	-		X1839
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.890