DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chb and Clasp2

DIOPT Version :9

Sequence 1:	NP_524651.2	Gene:	chb / 43901	FlyBaseID:	FBgn0021760	Length:	1491	Species:	Drosophila melanogaster
Sequence 2:	XP_038936601.1	Gene:	Clasp2 / 114514	RGDID:	619789	Length:	1553	Species:	Rattus norvegicus

Alignment Length:	1666	Identity:	494/1666 - (29%)
Similarity:	790/1666 - (47%)	Gaps:	308/1666 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KPSDLDGFIQQMPKADMRVKVQLAEDLVTF---------LSDDTNSIVCTDMGFLIDGLMPWLTG 60
            :|...:.|..|:.:.|:..::|..|:|:.:         |.||.:.:..|     :|.|..|:..
  Rat     2 EPRGAEYFCAQVLQKDVSGRLQAGEELLLYLGAPGAIPDLEDDPSRLAKT-----VDALTGWVGS 61

  Fly    61 SHFKIAQKSLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPP 125
            |:::::...||..|..:.||.:.|.:|...|...:|||:||::|.|||:||.|...||: ...||
  Rat    62 SNYRVSLLGLEILSAFVDRLSTRFKSYVTMVTTALIDRMGDAKDKVREEAQNLTLKLMD-EAAPP 125

  Fly   126 QALIDKLATSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQ 190
            ..:.::|| |.|||||.:.||.....::..|:.:|||.|.:...:|.:|.|.||....||.||:.
  Rat   126 MYIWEQLA-SGFKHKNFRSREGVCLCLIETLNMFGTQPLVISKLVPHLCVLFGDSNSQVRNAAVS 189

  Fly   191 TLVEIYKHVGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEGLLLPSALKNTNGNGVGLDEADNI 255
            .:||||:|||::||.||.:. |:|.::|.|:..|||:|:..|.::.|..|:.:     .|:.:::
  Rat   190 AVVEIYRHVGEKLRIDLCKR-DIPPARLEMILAKFDEVQNSGGMILSVCKDKS-----FDDEESV 248

  Fly   256 GLRERPTRMIK-----------RPLHSA--VSSSLRPKPNVNDVTGDAGAVTMESFESSFEVVPQ 307
            . ..||:....           .|::||  ..|:..||.......|.||||..:.|..:|..||.
  Rat   249 D-GNRPSSAASAFKVPAPKTPGNPVNSARKPGSAGGPKAGGTSKEGGAGAVDEDDFIKAFTDVPS 312

  Fly   308 LNIFHAKDMDDIYKQVLVIISDKNADWEKRVDALKKIRALLI---LSYHTQPQFVAVQLKELSLS 369
            :.|:.::::::...::..|:||...||::|.:||||||:||:   ..|....|.:.:....|.||
  Rat   313 IQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLS 377

  Fly   370 FVDILKEELRSQVIREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASASTIALKYI 434
                 .::|||||:||||||:|::|..|.||.|....:|:..|.||:.|||||:|::...|:::|
  Rat   378 -----AKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFI 437

  Fly   435 IKYTHAPKLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDADC 499
            |::||.|:|:.:.|.... |||..:|....|.:.||.:||||.:|||:|.||.:|:||.|.|||.
  Rat   438 IRHTHVPRLIPLITSNCT-SKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADA 501

  Fly   500 DARRHSRYAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGGGGT----------------- 547
            :||..:|..|...|.|||..|:.:|.:|:.:.|::|:...:..|...:
  Rat   502 EARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNR 566

  Fly   548 ------GTGTGTAPETRRTV--SRIGRTPGTLQKPTPSMRSISAVDTAAAQRAKVRAQYTLYSRQ 604
                  .|...:|...|.:|  |:....||:||      ||.|.:|..||..||.........|.
  Rat   567 PFSSKWSTANPSAVAGRVSVGGSKASPLPGSLQ------RSRSDIDVNAAAGAKAHHAAGQAVRS 625

  Fly   605 RKPLGPNNSNQAS----------MTGAAASGSLPRPRLNSNSGGTPATTPGSVTPRPRGRAG--- 656
            .: ||....|..|          |.|.|:.....|.:|:     ||....|:.....|||:.
  Rat   626 GR-LGAGALNPGSYASLEDTSDKMDGTASEDGRVRAKLS-----TPLVAVGNAKTDSRGRSRTKM 684

  Fly   657 VSQSQ------------------PGSRSTSPSTKLRDQYGGIGNYYRGA-----TGAIPKKASGI 698
            |||||                  .||||.||...|...  .:.....||     ..|..:|.|.|
  Rat   685 VSQSQRSSSPDKNEGSQSANTVGAGSRSGSPGRVLTTT--ALSTVSSGAQRILVNSASAQKRSKI 747

  Fly   699 PRSTASSRETSPTR---SGGGLMKRSMYSTGA---GSRRTPERNNPVR---PSAA---------- 744
            |||...|||.||:|   :....:.|...|.|.   .||.:....:|||   |.|:
  Rat   748 PRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLASRHHSRSTGAL 812

  Fly   745 -----------------ARLLAQSREAEHTLGVGDDGQPDYVSGDYMRSGGMRMGRK-------L 785
                             :..|:.|..|...|..|.|  .:....|.:..|.:|..:|       .
  Rat   813 YAPDVCGAAGPGYGMSQSSRLSSSVSAMRVLNTGSD--VEEAVADALLLGDIRTKKKPARRRYES 875

  Fly   786 MGRDESDDIDSEASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQFCAST 850
            .|....||.:|:|||.|||||:.|       .|.|:         .|.....:|:..::..|||:
  Rat   876 YGMHSDDDANSDASSACSERSYSS-------RNGSI---------PTYMRQTEDVAEVLNRCASS 924

  Fly   851 HWSERKDGLISLTQYLADGKELTQQQLKCVLDMFRKMFMDTHTK-VYSLFLDTVTELILVHANEL 914
            :|||||:||:.|...|.:.:.|::.:||.:.::|.:||.|.|.| |:|:||:|:.:.|.||.::|
  Rat   925 NWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKRVFSMFLETLVDFIQVHKDDL 989

  Fly   915 HEWLFILLTRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFRIISDSTQTPTTKTRIA 979
            .:|||:|||:|..|:|.|||.|:.:|:.|.|.|..|.||..||...|.|...|.||||:.|.::|
  Rat   990 QDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVA 1054

  Fly   980 ILRFLTDLANTYCKSSDFPSD--QSQACERTVLKLAQLAADQKSMELRSQARSCLVALYNLNTPQ 1042
            ||:::..||    |..| |.|  .|......|.::.....:.||.::|..|:|.|::|:.||||:
  Rat  1055 ILKYIETLA----KQMD-PGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPE 1114

  Fly  1043 MTLLLADLPKVYQDSARSCIHSHMRRQSQSCNSGANSPSSSPLSSSSPK-------PLQSPSVGP 1100
            .|:||..|||.:||.|...:|:|:|    :..:|..|...|||:..:|:       ||.||:
  Rat  1115 FTMLLGALPKTFQDGATKLLHNHLR----NTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPT--- 1172

  Fly  1101 FASLQSHHHQLSISSTSPRSRQSSVEQELLFSSELDIQHNIQKTSEEIRHCFGGQYQTALAPNGF 1165
                     ..|.::.||.:.....|.   .:|| ||..:::..:|.|::
  Rat  1173 ---------NTSQNTLSPSAFDYDTEN---MNSE-DIYSSLRGVTEAIQN--------------- 1209

  Fly  1166 NGHLQYHDQGQQDSCASLSSNSKTQS----------SANTTQSNTPESATMRLDN---------- 1210
                 :..:.|:|....|..:.|.:.          |......:.|:|:...|||
  Rat  1210 -----FSFRSQEDMSEPLKRDPKKEDGDTVCSGPGMSDPRAGGDAPDSSQPALDNKASLLHSVPL 1269

  Fly  1211 ----LERERTTQN---AKSP-----------TDDAKVITVSINMAENGELI------LASNLMES 1251
                ..|:....|   :.||           .|||......::: ::.:|:      |:::....
  Rat  1270 HSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSL-DHSDLVAELLKELSNHNERI 1333

  Fly  1252 EVVRVAL----TLTKDQPVELLQTSLTNLGICIKGGNCELPNKHFRSIMRMLLNILEAEHTDVVI 1312
            |..::||    .||:::...:.                   ::||::|:.:||..|..:...:..
  Rat  1334 EERKIALYELMKLTQEESFSVW-------------------DEHFKTILLLLLETLGDKEPTIRA 1379

  Fly  1313 AGLHVLSKIMRSNKMRHNWMHFLELILLKIIQCYQH-SKEALRDIDSMIPRIAPSLPLDLSINIV 1376
            ..|.||.:|:|....|  :.::.||.::|.::.::. .||.:|..:.....:|.|:..:..|.::
  Rat  1380 LALKVLKEILRHQPAR--FKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVL 1442

  Fly  1377 NPVIATGEFPTNLCAIKILLEVTEHHGSEITDAHLDIVFPNLARSADDTQSMVRKAAVFCIVKLY 1441
            .|:|.|.::|.||.|||:..:|.|....|..:..|..:.|.|.:..|:::|.||||.|||:|.::
  Rat  1443 CPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVH 1507

  Fly  1442 FVLGEEKVKPKLSVLNPSKVRLLNVYIEKQRNCISGGGSST 1482
            .|:|:| :||.||.|..||::|||:||::.:...:|...:|
  Rat  1508 AVIGDE-LKPHLSQLTGSKMKLLNLYIKRAQTGSAGADPTT 1547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787	7/27 (26%)
		CLASP_N	<74..211	CDD:289144	57/136 (42%)
		HEAT repeat	90..120	CDD:293787	15/29 (52%)
		HEAT_2	129..>210	CDD:290374	35/80 (44%)
		HEAT repeat	131..154	CDD:293787	10/22 (45%)
		HEAT repeat	165..195	CDD:293787	10/29 (34%)
		CLASP_N	316..536	CDD:289144	90/222 (41%)
Clasp2	XP_038936601.1	CLASP_N	<81..197	CDD:403532	48/117 (41%)
		HEAT repeat	91..121	CDD:293787	15/30 (50%)
		HEAT repeat	128..153	CDD:293787	10/25 (40%)
		HEAT repeat	165..194	CDD:293787	10/28 (36%)
		CLASP_N	326..538	CDD:403532	90/217 (41%)
		Spc7_N	<687..>809	CDD:373822	35/123 (28%)
		HEAT repeat	914..941	CDD:293787	11/26 (42%)
		HEAT repeat	953..984	CDD:293787	12/30 (40%)
		HEAT repeat	993..1022	CDD:293787	15/28 (54%)
		HEAT repeat	1033..1062	CDD:293787	11/28 (39%)
		HEAT repeat	1323..1345	CDD:293787	4/21 (19%)
		HEAT repeat	1358..1389	CDD:293787	9/30 (30%)
		HEAT repeat	1399..1432	CDD:293787	7/32 (22%)
		HEAT repeat	1477..1506	CDD:293787	13/28 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352153
Domainoid	1	1.000	340	1.000	Domainoid score	I1058
eggNOG	1	0.900	-	-		E1_KOG2956
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	599	1.000	Inparanoid score	I916
OMA	1	1.010	-	-		QHG59940
OrthoDB	1	1.010	-	-		D62708at33208
OrthoFinder	1	1.000	-	-		FOG0001668
OrthoInspector	1	1.000	-	-		otm44807
orthoMCL	1	0.900	-	-		OOG6_102734
Panther	1	1.100	-	-	O	PTHR21567
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1839
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810