DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chb and LOC101884241

DIOPT Version :9

Sequence 1:	NP_524651.2	Gene:	chb / 43901	FlyBaseID:	FBgn0021760	Length:	1491	Species:	Drosophila melanogaster
Sequence 2:	XP_021335613.1	Gene:	LOC101884241 / 101884241	-ID:	-	Length:	1453	Species:	Danio rerio

Alignment Length:	1603	Identity:	491/1603 - (30%)
Similarity:	779/1603 - (48%)	Gaps:	276/1603 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SDLDGFIQQMPKADMRVKVQLAEDLVTFLSDDTNS-IVCTDMGFL---IDGL-MPWLTGSHFKIA 66
            |.::..:.|:.:.::..:.|:|.:::.::.|...| .:..|...|   :|.| ..|:..|:||:|
Zfish     3 SSMEYIVDQVTQKEVGRRFQVAPEIIGYILDRQKSHDLEVDQSMLERMVDSLTTSWINASNFKVA 67

  Fly    67 QKSLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQALIDK 131
            ...:|..|.|:.||...|..:..||||.::||||||::.||::||.||..:|: :...||.:.|:
Zfish    68 LLGMEIVSALVSRLQEHFKTHIGTVLPSLMDRLGDSKEQVRDQAQSLLLKMMD-QAANPQFVWDR 131

  Fly   132 LATSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLVEIY 196
            : .|.|:|||.:.||.....:::.|:.||.|.|::...:|.:|.|||||:..||:||:..|||||
Zfish   132 M-LSGFRHKNNRTREAVCFCLISTLNVYGAQGLTLSKIVPHICHLLGDPSSQVRDAAMNCLVEIY 195

  Fly   197 KHVGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEGLLLPSALKNTNGNGVGLDEADNI------ 255
            :|||:|:|.||.: ..:|.|:|.::..:||.|::.||::..|.||       :|:.|::
Zfish   196 RHVGERVRVDLGK-KGLPQSRLNVIFSRFDDVQRSGLMIVCADKN-------IDDEDSVDGGRSS 252

  Fly   256 ----GLRERPTRMIKRPLHSAVSSSLRP-----KPNVNDVTGDAGAVTMESFESSFEVVPQLNIF 311
                |...|.|...:||    .|:|.||     :|:....:..||||..|.|..:||.||.:.|:
Zfish   253 SSSKGASVRRTGSTRRP----SSASSRPSSASRRPSSGKESCGAGAVDEEDFIRAFEDVPTVQIY 313

  Fly   312 HAKDMDDIYKQVLVIISDKNADWEKRVDALKKIRALLILSYHTQPQFVAVQLKELSLSFVDILKE 376
            .|::::|...:|..|:||:..|||:||.||||:|:||:........| ...|::|..:| .:..:
Zfish   314 SARELEDSINKVREILSDEKHDWEQRVAALKKVRSLLLAGAGDYDGF-CHHLRQLDAAF-KLSAK 376

  Fly   377 ELRSQVIREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASASTIALKYIIKYTHAP 441
            :|||||:||||||:.::|..|.:|.|....:|:..|:||:.|||||:|::.:.|::.||.:||.|
Zfish   377 DLRSQVVREACITLGHLSSVLGSKFDHGAENIMPALLNLLPNSAKVMATSGSAAIRIIILHTHYP 441

  Fly   442 KLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDADCDARRHSR 506
            :|:.|.|.|. .|||..:|....|.:.|:.:||||.||||:.:||.:|:||.:.|||.:||..:|
Zfish   442 RLIPIMTSTC-MSKSVVVRRRCFEFLDLMLQEWQTTALERHVSVLMETIKKGVHDADSEARSLAR 505

  Fly   507 YAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGGGGTGTGTGTAPETRRTVSRIGRTPGTL 571
            ..||||..||...||.::..|:.:.||||:.:.:      :.....:.|::.|:.|   .:..:|
Zfish   506 KCYWAFHGHFSREADLLFQALEASYQRALQSQLQ------SSDSIMSLPQSDRSSS---SSQESL 561

  Fly   572 QKP----TPSMRSISAVDTAAA-----------QRAKVRAQYTLYSRQRKPLGPNNSNQASMTG- 620
            .:|    ||:..|:|.....:|           .|:.|.....:.::.|.|..|..:..:|.|.
Zfish   562 SRPTTARTPAASSLSRAKVTSAGSCSSSGSLQRSRSDVDVNAAVCAKSRMPAVPTAAPFSSATAL 626

  Fly   621 -AAASGSLPRPRLNSNSGGTPATTPGSVT-PRPRGRA-GVSQSQPGSRSTSPSTKLRDQYGGIGN 682
             ..:..||.|.|....|..||.....||| .|.|.|| ..|||||||||:||...|  .||.:
Zfish   627 PPGSYASLGRVRTRRQSSETPTGGGASVTDSRGRSRAKAASQSQPGSRSSSPRKLL--SYGRV-- 687

  Fly   683 YYRGATGAIP----KKASGIPRSTASSRETSPTRSG---GGLMKRSMYSTGAG---SRRTPERNN 737
                  ..:|    .:.|.||||...||||||:|:.   |..:.|...|.|..   ||.:....:
Zfish   688 ------SVVPATHTHRLSKIPRSQGCSRETSPSRAAQARGSRIPRPSVSQGCSRDTSRESSRDTS 746

  Fly   738 PVR---PSAAAR--------------------LLAQSR-----EAEHTLGVGDDGQPDYVS---- 770
            |.|   |.|:.|                    ||.|:|     .|...|..|.:.:.....
Zfish   747 PARGFSPLASHRHCRSTGALTGTDGLQTDRFGLLHQARISASVNAMRILNTGTEVEAAVADALLL 811

  Fly   771 GDYM-RSGGMRMGRKLMGRDESDDIDSEASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQR 834
            ||.. :.|.:|...:..|....||::|:||||||||||.|       .|.|....|.|
Zfish   812 GDSRNKRGQVRRRYESPGVCSDDDVNSDASSVCSERSFSS-------RNGSAVPHHLR------- 862

  Fly   835 APFDDIETIIQFCASTHWSERKDGLISLTQYLADGKELTQQQLKCVLDMFRKMFMDTHTK-VYSL 898
             ..:|:..|:..|||.:.:|||:||:||...|.:.:.|::.:||.:.::|.:||.|.|:| |:|:
Zfish   863 -QTEDVAEILNRCASANCTERKEGLMSLQNLLKNQRVLSRVELKRLCEIFTRMFADPHSKRVFSM 926

  Fly   899 FLDTVTELILVHANELHEWLFILLTRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFR 963
            ||:|:.:.|.:|..:|.:|||||||:|..|.|.|||.|:.:::.:.|.|..|.||...|...|.|
Zfish   927 FLETLLDFISLHREDLQDWLFILLTQLLKKTGVDLLGSVQARVQRALDVTRESFPYDQQFNILMR 991

  Fly   964 IISDSTQTPTTKTRIAILRFLTDLANTYCKSSDFPSDQSQACERTVLKLAQLAADQKSMELRSQA 1028
            .|.|.||||..|....::                                          |:|||
Zfish   992 FIVDQTQTPNLKVGHTVM------------------------------------------LKSQA 1014

  Fly  1029 RSCLVALYNLNTPQMTLLLADLPKVYQDSARSCIHSHMRRQSQSCNSGANSPSSSPLSSSSP--- 1090
            ...:::......|..|   ...|..   |..|..|:.:   |.|...|.:|.|||.|:|..|
Zfish  1015 SPEVISSVKPPKPPAT---RSSPLT---SPTSGTHTGL---SPSRLWGWSSKSSSLLASPHPGSA 1070

  Fly  1091 -KPLQSPSVGPFASLQSHHHQLSISSTSPRS----RQSSVEQELLFSSELDIQ--HNIQKTSEEI 1148
             .||::|......||      |...:.:..|    |.:...|...|.|:.||:  ....|..|.|
Zfish  1071 TPPLRAPRRAYSPSL------LEYDTENMNSEDIFRVTEAIQSFSFRSQEDIETAKRDAKREETI 1129

  Fly  1149 RHCFGGQYQTALAPNGFNG----------------HLQYHDQGQQDSCA-----SLSSNSKTQSS 1192
                 |...:|:...|...                ..:|:.....||.:     :|:....|:.:
Zfish  1130 -----GVLSSAMMEGGRTALDNKTSLLNMPSPRPWMREYNPYNYSDSISAYEKGALAGFEDTEQT 1189

  Fly  1193 ANTTQSNTPESATMRLDNLERERTTQNAKSPTDDAKVITVSINMAENGELI--LASNLMESEVVR 1255
            .:..|.::.|:..|.....        :..|....:::         |||:  |::.....|..|
Zfish  1190 RDERQQDSGENKVMHPKGF--------SAGPRQQLELV---------GELLKELSNRSARVEERR 1237

  Fly  1256 VALTLTKDQPVELLQTSLTNLGICIKGGNCELPNKHFRSIMRMLLNIL-EAEHTDVVIAGLHVLS 1319
            .||       :|||:.:        :..:..:..:||:|::.:||..| :.:||...:| |.||.
Zfish  1238 AAL-------LELLKVT--------RDDSLSVWEEHFKSMLLLLLETLGDTDHTVRALA-LRVLK 1286

  Fly  1320 KIMRSNKMRHNWMHFLELILLKIIQCYQH-SKEALRDIDSMIPRIAPSLPLDLSINIVNPVIATG 1383
            :|:||...|  :.::.||.::|.::.::. .||.:|..:.....:|.|:..:..|.::.|:|.|.
Zfish  1287 EILRSQPER--FKNYAELTIMKTLEAHKDCHKEVVRAAEETACTLAGSIHSEQCIKVLCPIIQTA 1349

  Fly  1384 EFPTNLCAIKILLEVTEHHGSEITDAHLDIVFPNLARSADDTQSMVRKAAVFCIVKLYFVLGEEK 1448
            ::|.:|.|||:...|.|....:.....|..:.|.|.:..|:|:|.||||:|||:|.:|.|:||:
Zfish  1350 DYPISLSAIKMQTRVIERISHDSLLQLLPDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIGED- 1413

  Fly  1449 VKPKLSVLNPSKVRLLNVYIEKQRNCISGGGSSTKNSSAASSS 1491
            :||.:..|..||::|||:||::         :.|.||:::|||
Zfish  1414 LKPHIQQLTGSKMKLLNLYIKR---------AQTINSTSSSSS 1447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787	11/31 (35%)
		CLASP_N	<74..211	CDD:289144	60/136 (44%)
		HEAT repeat	90..120	CDD:293787	17/29 (59%)
		HEAT_2	129..>210	CDD:290374	36/80 (45%)
		HEAT repeat	131..154	CDD:293787	7/22 (32%)
		HEAT repeat	165..195	CDD:293787	13/29 (45%)
		CLASP_N	316..536	CDD:289144	93/219 (42%)
LOC101884241	XP_021335613.1	CLASP_N	<81..206	CDD:315101	55/126 (44%)
		HEAT repeat	91..121	CDD:293787	17/30 (57%)
		HEAT repeat	127..153	CDD:293787	8/26 (31%)
		HEAT repeat	165..194	CDD:293787	13/28 (46%)
		CLASP_N	324..535	CDD:315101	92/213 (43%)
		Herpes_ICP4_C	594..>769	CDD:332854	59/184 (32%)
		HEAT repeat	1300..1328	CDD:293787	6/27 (22%)
		HEAT repeat	1337..1366	CDD:293787	10/28 (36%)
		HEAT repeat	1377..1403	CDD:293787	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62708at33208
OrthoFinder	1	1.000	-	-		FOG0001668
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920