DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chb and clasp1

DIOPT Version :9

Sequence 1:	NP_524651.2	Gene:	chb / 43901	FlyBaseID:	FBgn0021760	Length:	1491	Species:	Drosophila melanogaster
Sequence 2:	NP_001090708.1	Gene:	clasp1 / 100036688	XenbaseID:	XB-GENE-6049805	Length:	1452	Species:	Xenopus tropicalis

Alignment Length:	1591	Identity:	518/1591 - (32%)
Similarity:	809/1591 - (50%)	Gaps:	257/1591 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LDGFIQQMPKADMRVKVQLAEDLVTFLSDDTNSIVC----TDMGFLIDGL-MPWLTGSHFKIAQK 68
            :|.::.|:.:.|:..::|:..||:.:|||...||..    |.:..::||| ..|:..|::|:|..
Frog     5 MDYWLGQIQQKDVGKRLQVGPDLMEYLSDRQKSIDLEQDQTVLDRMVDGLATSWVNSSNYKVALL 69

  Fly    69 SLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQALIDKLA 133
            .::..|.|:.||...|.:...||||.::|||||::|:|||:.|.||..:|| :...||.:.:::
Frog    70 GMDILSALVTRLQDRFRSQIGTVLPSLMDRLGDAKDSVREQDQNLLIKIME-QASNPQYVWERM- 132

  Fly   134 TSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLVEIYKH 198
            .|.|||||.:.||.....::..|:.||...|::...:|.:|.|||||...||:|||..|||||:|
Frog   133 FSGFKHKNFRTREGVCLCLIATLNVYGAHSLTLSKIVPHICNLLGDPNSQVRDAAINCLVEIYRH 197

  Fly   199 VGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEG-LLLPSALKN------TNGN----------- 245
            ||:|:|.||.: ..:|.|:|.::..|||:|::.| ::|.||.||      .:||
Frog   198 VGERVRADLSK-KGLPQSRLNVIFTKFDEVQKSGTMILSSADKNFDDEDSVDGNRPSSASSSASS 261

  Fly   246 --------GVGLDEADNIGLRERPTRMIKRPLHSAVSSSLRPKPNVNDVTGDAGAVTMESFESSF 302
                    ||.|      |...||.           :||..|||......| ||.|..|.|...|
Frog   262 KAPQAARRGVSL------GTARRPG-----------TSSAAPKPGGTAKEG-AGGVDEEDFIRGF 308

  Fly   303 EVVPQLNIFHAKDMDDIYKQVLVIISDKNADWEKRVDALKKIRALLILSYHTQPQFVAVQLKELS 367
            |.||.:.|:.::|:::...::..|:||...|||:|:.||||||:||:........|.. ||:.|.
Frog   309 EDVPTVQIYSSRDLEESLNKIREILSDDKHDWEQRISALKKIRSLLLAGAAEYDTFFP-QLRLLD 372

  Fly   368 LSFVDILKEELRSQVIREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASASTIALK 432
            .:| .:..::|||||:||||||:.::|..|.||.|....:|:..:.||:.||||::|::..:|::
Frog   373 GAF-KLSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTVFNLVPNSAKIMATSGVVAIR 436

  Fly   433 YIIKYTHAPKLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDA 497
            .||:.||.|:|:.|.|.... |||..:|....|.:.||.:||||.:|||:.:||.:|:||.|.||
Frog   437 LIIRQTHVPRLIPIITSNCT-SKSVAVRRRCYEFLDLLLQEWQTHSLERHVSVLAETIKKGIHDA 500

  Fly   498 DCDARRHSRYAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGG----GGTGTGTGTAPE-- 556
            |.:||..:|..||.|..||.:.|:|::.||:.:.|:||:...:....    ..:...:.::.|
Frog   501 DSEARIVARKCYWGFHSHFSKEAEQLFHTLESSYQKALQSHLKNSDSIVSLPQSDRSSSSSQESL 565

  Fly   557 ----------TRRTVSRIG-----RTPGTLQKPTPSMRSISAVDTAAAQRAKVRAQYTLYSRQRK 606
                      |..||||..     .|||:||      ||.|.:|..||..||.:|      ....
Frog   566 NRPLSAKRSPTGSTVSRASTATSKSTPGSLQ------RSRSDIDVNAATCAKSKA------TSGA 618

  Fly   607 PLGPNNSNQASMTGAAAS-GSLPRPRLNSNSGGTPATTPGSVTPRPRGRAGVSQSQPGSRSTSPS 670
            ...|.:|..|...|:.|| |.:...|.:|.|..:.|:||.....|.|.:. ||||||||||:||.
Frog   619 SAAPFSSVAALPPGSYASLGRIRTRRQSSGSTTSTASTPADTRGRSRAKV-VSQSQPGSRSSSPG 682

  Fly   671 TKLRDQYGGIGNYYRGATG--AIP-----KKASGIPRSTASSRETSPTRSGGGLMKRSMYSTGAG 728
            ..|...||||      |:|  .:|     :|.|.||||...||||||:|.|   :.|...|
Frog   683 KLLGSGYGGI------ASGPQRVPQMPSSEKRSKIPRSQGCSRETSPSRIG---LDRFGIS---- 734

  Fly   729 SRRTPERNNPVRPSAAARLLAQSREAEHTLGVGDDGQPDYVSGDYMRSGGMRMGRKLMGRDESDD 793
                    .|.|..:|.|:|:.|.:.|..:            .|.::. .:|...:..|....||
Frog   735 --------QPGRIPSAMRVLSSSTDLEAAV------------ADALKK-PVRRRYEPYGMYSDDD 778

  Fly   794 IDSEASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQFCASTHWSERKDG 858
            .:|:|||.|||||:.|.  .|...:|              ....:|:..::..|||::|||||:|
Frog   779 ANSDASSACSERSYSSK--NGGIPHY--------------LRQTEDVAEVLNHCASSNWSERKEG 827

  Fly   859 LISLTQYLADGKELTQQQLKCVLDMFRKMFMDTHTK-VYSLFLDTVTELILVHANELHEWLFILL 922
            ||.|...|...:.|::.:||.:.::|.:||.|.|:| |:|:||:|:.:.:::|.::|.:||||||
Frog   828 LIGLQNLLKSQRTLSRVELKRLCEIFTRMFADPHSKRVFSMFLETLVDFVIIHKDDLQDWLFILL 892

  Fly   923 TRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFRIISDSTQTPTTKTRIAILRFLTDL 987
            |:|..|:|.|||.|:.:|:.|.|.|..:.||...|...|.|.|.|.||||..|.::|||:::..|
Frog   893 TQLLKKMGADLLGSVQAKVQKALDVTRDSFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESL 957

  Fly   988 ANTYCKSSDFPSD--QSQACERTVLKLAQLAADQKSMELRSQARSCLVALYNLNTPQMTLLLADL 1050
            |    :..| |:|  .|......|.::.....:.||.::|..|:..|::|:.||||:.|:||..|
Frog   958 A----RQMD-PTDFVNSSETRLAVSRIITWTTEPKSSDVRKAAQVVLISLFELNTPEFTMLLGAL 1017

  Fly  1051 PKVYQDSARSCIHSHMRRQSQSCNSGANSPSS------SPLSSSSPKPLQSP---SVGPFASLQS 1106
            ||.:||.|...:|:|::..|   ||...|||:      |..|||...||.||   |.|..:....
Frog  1018 PKTFQDGATKLLHNHLKNSS---NSSMGSPSNTIGRTPSRHSSSRASPLTSPTNCSHGGLSPSML 1079

  Fly  1107 HHHQLSISS----TSPRSRQSSVEQELLFSSELDIQHNIQ---KTSEEIRHCFGGQYQTALAPNG 1164
            .:...:::|    :|.|....::| :..|.|::|:...::   |...|:..|
Frog  1080 DYDTENLNSDEIYSSLRGVTEAIE-KFSFRSQVDLNEPVRREGKKESELGSC------------- 1130

  Fly  1165 FNGHLQYHDQGQQDSCASLSSNSKTQSSANTTQSNTPESATMRLDNLERERTTQNAKSPTD---- 1225
                    |.|.....:.|...           ::..|...|.|||......||..::.|.
Frog  1131 --------DVGIASPASDLRGG-----------TDMVEGGRMALDNKTSLLNTQPPRAFTGPRGR 1176

  Fly  1226 --DAKVITVSINMAENGELILASNLMESEVVRVALTLTKDQPV-------ELLQTSLTNLGICI- 1280
              :....:.|||..:  :..|...:.:.::.::     :|.|:       :||: .|:|....:
Frog  1177 EYNPYAYSDSINSYD--KTALKEAVFDDDMDQL-----RDVPIDHSDLVADLLK-ELSNHNERVE 1233

  Fly  1281 --KGGNCELP-----------NKHFRSIMRMLLNIL-EAEHTDVVIAGLHVLSKIMRSNKMRHNW 1331
              ||..|||.           .:||::|:.:||..| :.:|....:| |.||.:|:|:...|  :
Frog  1234 ERKGALCELLKITREDSLAVWEEHFKTILLLLLETLGDKDHAIRALA-LRVLREILRNQPAR--F 1295

  Fly  1332 MHFLELILLKIIQCYQHS-KEALRDIDSMIPRIAPSLPLDLSINIVNPVIATGEFPTNLCAIKIL 1395
            .::.||.::|.::.::.| ||.:|..:.....:|.|:..:..|.::.|:|.|.::|.||.|||:.
Frog  1296 KNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLAGSIHPEQCIKVLCPIIQTADYPINLAAIKMQ 1360

  Fly  1396 LEVTEHHGSEITDAHLDIVFPNLARSADDTQSMVRKAAVFCIVKLYFVLGEEKVKPKLSVLNPSK 1460
            .:|.|....|.....|..:.|.|.:..|:|:|.||||:|||:|.:|.|:||| :||.|:.|...|
Frog  1361 TKVIERISKESLHQILPDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIGEE-LKPYLAQLTGGK 1424

  Fly  1461 VRLLNVYIEKQRNCISGGGSSTKNSSAASSS 1491
            ::|||:||::         :.|.||:::|||
Frog  1425 MKLLNLYIKR---------AQTTNSNSSSSS 1446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787	9/28 (32%)
		CLASP_N	<74..211	CDD:289144	61/136 (45%)
		HEAT repeat	90..120	CDD:293787	17/29 (59%)
		HEAT_2	129..>210	CDD:290374	36/80 (45%)
		HEAT repeat	131..154	CDD:293787	8/22 (36%)
		HEAT repeat	165..195	CDD:293787	14/29 (48%)
		CLASP_N	316..536	CDD:289144	90/219 (41%)
clasp1	NP_001090708.1	HEAT 1. /evidence=ECO:0000255	68..87		5/18 (28%)
		CLASP_N	<77..208	CDD:315101	60/132 (45%)
		HEAT 2. /evidence=ECO:0000255	88..124		18/36 (50%)
		HEAT repeat	93..120	CDD:293787	14/26 (54%)
		HEAT repeat	132..156	CDD:293787	8/24 (33%)
		HEAT 3. /evidence=ECO:0000255	163..200		20/36 (56%)
		HEAT repeat	167..194	CDD:293787	14/26 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..299		18/77 (23%)
		CLASP_N	328..539	CDD:315101	90/213 (42%)
		HEAT 4. /evidence=ECO:0000255	407..442		11/34 (32%)
		HEAT 5. /evidence=ECO:0000255	443..479		14/36 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..735		71/223 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	771..792		11/20 (55%)
		HEAT repeat	809..836	CDD:293787	12/26 (46%)
		HEAT repeat	848..879	CDD:293787	11/30 (37%)
		HEAT repeat	888..917	CDD:293787	16/28 (57%)
		HEAT 6. /evidence=ECO:0000255	926..963		16/41 (39%)
		HEAT repeat	928..957	CDD:293787	12/28 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1033..1076		16/45 (36%)
		HEAT repeat	1195..1224	CDD:293787	5/34 (15%)
		HEAT repeat	1239..1289	CDD:293787	15/50 (30%)
		HEAT 7. /evidence=ECO:0000255	1256..1293		13/37 (35%)
		HEAT repeat	1299..1331	CDD:293787	8/31 (26%)
		HEAT 8. /evidence=ECO:0000255	1374..1411		16/36 (44%)
		HEAT repeat	1376..1402	CDD:293787	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	351	1.000	Domainoid score	I1012
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41024
Inparanoid	1	1.050	666	1.000	Inparanoid score	I755
OMA	1	1.010	-	-		QHG59940
OrthoDB	1	1.010	-	-		D62708at33208
OrthoFinder	1	1.000	-	-		FOG0001668
OrthoInspector	1	1.000	-	-		otm47849
Panther	1	1.100	-	-	LDO	PTHR21567
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2455
SonicParanoid	1	1.000	-	-		X1839
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.200