DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and PDR18

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_014468.3	Gene:	PDR18 / 855807	SGDID:	S000005353	Length:	1333	Species:	Saccharomyces cerevisiae

Alignment Length:	794	Identity:	198/794 - (24%)
Similarity:	332/794 - (41%)	Gaps:	234/794 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 GKSILVDAKSNSPASLSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQPQHS-----LQLT-- 354
            |...||..|....|     .::|.::...:::.|.:|.........|.|....|     |:.|
Yeast   669 GGDALVVKKGTKNA-----IQRSWSSKNDEENLNASIATQDMKEIASSNDDSTSADFEGLESTGV 728

  Fly   355 --FQNLN--VLHN--ERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHID--SGSVFL 411
              ::|::  :.|:  :|::|..|||:..|..:.|::|.||:||||||:.|: ||::.  :|.:.:
Yeast   729 FIWKNVSFTIPHSSGQRKLLDSVSGYCVPGTLTALIGESGAGKTTLLNTLA-QRNVGTITGDMLV 792

  Fly   412 NREPLTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCC 476
            :..|:...::||.|||.|:::...:||::|::.::|.:|.|:|:|.||||..|:.|:..||:...
Yeast   793 DGLPMDASFKRRTGYVQQQDLHVAELTVKESLQFSARMRRPQSIPDAEKMEYVEKIISILEMQEF 857

  Fly   477 QQTKFGDYLNRGLSGGEKKRANIACELLTNP-LLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQK 540
            .:...|: :..||:..::|:.:|..||:..| ||:.||||||||||.||.:::|:|||.| |..:
Yeast   858 SEALVGE-IGYGLNVEQRKKLSIGVELVGKPDLLLFLDEPTSGLDSQSAWAVVKMLKRLA-LAGQ 920

  Fly   541 TIVISVHQPSSQMFHMFDKLLLLHQ-GRTAYFGDV----QNIYRHFEDIGV-TIKPHYNPADFVL 599
            :|:.::||||:.:|..||:||||.: |:|.|||::    .::.::||..|. ..:.:.|||:::|
Yeast   921 SILCTIHQPSATLFEQFDRLLLLGKGGQTIYFGEIGKNSSSVIKYFEKNGARKCQQNENPAEYIL 985

  Fly   600 EQL---------KSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDD 655
            |.:         ::.|||.:|       || .|.|                           |::
Yeast   986 EAIGAGATASVQQNWPDIWQK-------SH-EYAN---------------------------INE 1015

  Fly   656 IINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGS 720
            .||:.....|:      ..||.|                    |...|.:::
Yeast  1016 KINDMIKDLSS------TTLHKT--------------------ATRASKYAT------------- 1041

  Fly   721 GPGHSADDDWLSYPTSFHTQFCVL--SSRNFREAKPRMLSKLNWFQTIGLALMAGAIWFQLPRTE 783
                       ||...||.   ||  ||..|       ...||:.....:.||...::.
Yeast  1042 -----------SYSYQFHH---VLKRSSLTF-------WRNLNYIMAKMMLLMISGLFI------ 1079

  Fly   784 EFLHDLQGWMFFS--------QTYWMLFALFGAL-NSFPS-----EREVVSK------ERRSGAY 828
                   |:.||.        |.  .|||.|.|: .|.|:     ||..|:|      |.:|..:
Yeast  1080 -------GFTFFHVGVNAIGLQN--SLFACFMAIVISAPATNQIQERATVAKELYEVRESKSNMF 1135

  Fly   829 RLSAYYLAKMCAELPLVITLPTVYLMISYPMLG----CTSLKLFFL--MLIFLLINTIVAQSVGF 887
            ..|...:.....|||..:...|::.:.||..||    .:...:|:|  .::|.|          :
Yeast  1136 HWSLLLITHYLNELPYHLLFSTIFFVSSYFPLGVFTEASRSSVFYLNYAILFQL----------Y 1190

  Fly   888 FIGACCMDMNVSITLSALYTLATQLFGGYLSSRI-------PEGLS---WIRYTSMIHYAY--QN 940
            :||...|.:.:|..|.:    |..:.|..||..:       |..|.   |.....:..|.|  ||
Yeast  1191 YIGLALMILYMSPNLQS----ANVIVGFILSFLLSFCGAVQPASLMPGFWTFMWKLSPYTYFLQN 1251

  Fly   941 MQILEFREGAAIGCG-------SPSSYEICKQQSTEFIPY-----------------------EE 975
            :..|...: ..:.|.       :|...:.|.:.:..|..:                       |.
Yeast  1252 LVGLLMHD-KPVRCSKKELSLFNPPVGQTCGEFTKPFFEFGTGYIANPDATADCAYCQYKVGDEY 1315

  Fly   976 ILKAQNSTSPLWLN 989
            :.:...|.|.||.|
Yeast  1316 LARINASFSYLWRN 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	91/238 (38%)
		3a01204	363..1009	CDD:273361	183/717 (26%)
		ABC2_membrane	744..943	CDD:279410	54/238 (23%)
PDR18	NP_014468.3	3a01205	1..1333	CDD:273362	198/794 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I2724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	2	2.000