DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and PDR5

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_014796.3	Gene:	PDR5 / 854324	SGDID:	S000005679	Length:	1511	Species:	Saccharomyces cerevisiae

Alignment Length:	818	Identity:	199/818 - (24%)
Similarity:	322/818 - (39%)	Gaps:	231/818 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 KSILVDAKSNSPASLSYHFEKSAAANQQKQ-----------HHNINICNSHHPHHHSQNQPQHSL 351
            :.:|.:..:|.|.::.   |:|..::.:|.           :..|.:..|....|
Yeast   819 RGVLTEKNANDPENVG---ERSDLSSDRKMLQESSEEESDTYGEIGLSKSEAIFH---------- 870

  Fly   352 QLTFQNL----NVLHNERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQ--RHIDSGSVF 410
               ::||    .:....|:||::|.|:|.|..:.|:||.||:|||||||||:.:  ..:.:|.:.
Yeast   871 ---WRNLCYEVQIKAETRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGDIL 932

  Fly   411 LNREPLTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGC 475
            :|..|..|.:.|.|||..|:::.....|:||::.::|.||.|..:...||.|.|:.:::.||:
Yeast   933 VNGIPRDKSFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPAEVSIEEKNRYVEEVIKILEM-- 995

  Fly   476 CQQTKFGDYL----NRGLSGGEKKRANIACELLTNP-LLMLLDEPTSGLDSHSAISLMKVLKRYA 535
               .|:.|.:    ..||:..::||..|..||...| ||:.||||||||||.:|.|:.:::|:.|
Yeast   996 ---EKYADAVVGVAGEGLNVEQRKRLTIGVELTAKPKLLVFLDEPTSGLDSQTAWSICQLMKKLA 1057

  Fly   536 QLEQKTIVISVHQPSSQMFHMFDKLLLLHQ-GRTAYFGDV----QNIYRHFEDIGVTIKP-HYNP 594
            ...| .|:.::||||:.:...||:||.:.: |:|.||||:    :.:..:||..|....| ..||
Yeast  1058 NHGQ-AILCTIHQPSAILMQEFDRLLFMQRGGKTVYFGDLGEGCKTMIDYFESHGAHKCPADANP 1121

  Fly   595 ADFVLEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINN 659
            |:::||.:.:.|                        .||.||                      :
Yeast  1122 AEWMLEVVGAAP------------------------GSHANQ----------------------D 1140

  Fly   660 YYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGH 724
            ||....|.                 ||.......|.|...:.....|..|:.|.|.:|..
Yeast  1141 YYEVWRNS-----------------EEYRAVQSELDWMERELPKKGSITAAEDKHEFSQS----- 1183

  Fly   725 SADDDWLSYPTSFHTQFCVLSSRNFRE--AKPRML-SKLNWFQTIGLALMAGAIWFQLPRTEEFL 786
                  :.|.|.      ::|.|.|::  ..|..| ||  :..||...|..|..:|:...:   |
Yeast  1184 ------IIYQTK------LVSIRLFQQYWRSPDYLWSK--FILTIFNQLFIGFTFFKAGTS---L 1231

  Fly   787 HDLQGWMFFSQTYWMLF--ALFGALNSFPSEREVV-SKERRSGAYRLSAYYLAKMCAELPLVITL 848
            ..||..|.....:.::|  .|...|.||..:|::. ::||.|..:...::..|::..|:|..|..
Yeast  1232 QGLQNQMLAVFMFTVIFNPILQQYLPSFVQQRDLYEARERPSRTFSWISFIFAQIFVEVPWNILA 1296

  Fly   849 PTVYLMISYPMLGCTSL-----------KLFFLMLIFLLINTIVAQSVGFFIGACCMDMNV---- 898
            .|:...|.|..:|..|.           .||:|.            |..|::....|.:.|
Yeast  1297 GTIAYFIYYYPIGFYSNASAAGQLHERGALFWLF------------SCAFYVYVGSMGLLVISFN 1349

  Fly   899 SITLSALYTLATQLFGGYLS--------SRIPEGLSWIRYTSMIHYAYQ---------------N 940
            .:..||. .||:.||...||        |.:|....::...|.:.|..|               :
Yeast  1350 QVAESAA-NLASLLFTMSLSFCGVMTTPSAMPRFWIFMYRVSPLTYFIQALLAVGVANVDVKCAD 1413

  Fly   941 MQILEFREGAAIGCGSPSSYEICKQQSTEFIPYEEILKA-----QNST----------------- 983
            .::|||...:.:.||          |..|  ||.::.|.     :|:|
Yeast  1414 YELLEFTPPSGMTCG----------QYME--PYLQLAKTGYLTDENATDTCSFCQISTTNDYLAN 1466

  Fly   984 -----SPLWLNTLILMMFFLVFRCLGYAVLRFLRCPKK 1016
                 |..|.|..|.:.:.......|.......|.|||
Yeast  1467 VNSFYSERWRNYGIFICYIAFNYIAGVFFYWLARVPKK 1504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	84/233 (36%)
		3a01204	363..1009	CDD:273361	184/729 (25%)
		ABC2_membrane	744..943	CDD:279410	54/242 (22%)
PDR5	NP_014796.3	ABC_trans_N	46..152	CDD:405234
PDR5	NP_014796.3	3a01205	100..1503	CDD:273362	196/815 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I2724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	2	2.000