DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E23 and Abcg1

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_445954.2	Gene:	Abcg1 / 85264	RGDID:	620294	Length:	666	Species:	Rattus norvegicus

Alignment Length:	789	Identity:	223/789 - (28%)
Similarity:	358/789 - (45%)	Gaps:	155/789 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 AATSVASSDSSASSSASSTSSSSSSSTSSEFTHTSQTTIPSTDNLTSSNGLANIGKSILVDAKSN 307
            ||.||.::.::::.||:.|...|              ...|.|.:.|||          ||....
  Rat     6 AAFSVGTAMNASNYSAAMTEPKS--------------VCVSVDEVVSSN----------VDELET 46

  Fly   308 SPASLSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQPQH-SLQLTFQNLNVLHNE------- 364
            .  .|:.|.:|              :.|:........:.|:. ::.:.|::|:....|
  Rat    47 D--LLNGHLKK--------------VDNNFTEAQRFSSLPRRAAVNIEFKDLSYSVPEGPWWRKK 95

  Fly   365 --RQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHID-SGSVFLNREPLTKKWRRRIG- 425
              :.:|..:||..:..|::|||||||:||:||::.|:|.|... .|:|.:|..|...:..|::.
  Rat    96 GYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGMPRDLRCFRKVSC 160

  Fly   426 YVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLS 490
            |::|:::..|.||::|.::.:|.|:|.|......:|  |..||.||.|..|..|:.|     .||
  Rat   161 YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREM--VKEILTALGLLPCANTRTG-----SLS 218

  Fly   491 GGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFH 555
            ||::||..||.||:.||.:|..|||||||||.|...::.::|..|| ..::||.::||||:::|.
  Rat   219 GGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ-GGRSIVCTIHQPSAKLFE 282

  Fly   556 MFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLK-SHPDIREKLFIAAKES 619
            :||:|.:|.||:..|.|.|.|:..:..|:|:....::||||||:|... .:.|...:|..|.:|
  Rat   283 LFDQLYVLSQGQCVYRGKVSNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVRE- 346

  Fly   620 HGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCRV 684
                   ....|.:..::...|.              :|.:...|.                  .
  Rat   347 -------GMCDSDYKRELGGDGD--------------VNPFLWHRP------------------A 372

  Fly   685 EEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSSRNF 749
            |||                   |.:...|||:||                 |..||||:|..|.|
  Rat   373 EED-------------------SASMEGCHSFSA-----------------SCLTQFCILFKRTF 401

  Fly   750 RE-AKPRMLSKLNWFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSFP 813
            .. .:..:|:.|.....||:.|:.|.::..:....:.:....|::|||..:.|..||...:.:||
  Rat   402 LSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFP 466

  Fly   814 SEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCTSLKLFFLMLIFL-LI 877
            .|..|..:|..:..|.|.||||||..|::|..|..|..|..|.|.|....|..:.|::...| .:
  Rat   467 LEMSVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTM 531

  Fly   878 NTIVAQSVGFFIGACCMDMNVSITLSALYTLATQLFGGYLSS--RIPEGLSWIRYTSMIHYAYQN 940
            .::||||:|..|||....:.|:..:..:..:...||.|:..|  .||..|.|:.|.|.:.|.::.
  Rat   532 TSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEG 596

  Fly   941 MQILEF----REGAAIGCGSPSSYEICKQQSTEFIPYEEILKAQNSTSPLWLNTLILMMFFLVFR 1001
            : ||..    ||.  :.|   ...|.|..|.:|.|..|  |..:|  :.|:|:.::|.:||:..|
  Rat   597 V-ILSIYGLDRED--LHC---DIAETCHFQKSEAILRE--LDVEN--AKLYLDFIVLGIFFISLR 651

  Fly  1002 CLGYAVLRF 1010
            .:.|.|||:
  Rat   652 LIAYFVLRY 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	86/232 (37%)
		3a01204	363..1009	CDD:273361	199/665 (30%)
		ABC2_membrane	744..943	CDD:279410	60/202 (30%)
Abcg1	NP_445954.2	3a01204	60..666	CDD:273361	204/695 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720