DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and PDR15

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_010694.1	Gene:	PDR15 / 852015	SGDID:	S000002814	Length:	1529	Species:	Saccharomyces cerevisiae

Alignment Length:	825	Identity:	194/825 - (23%)
Similarity:	327/825 - (39%)	Gaps:	241/825 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 DNLTSSNGLANIGKSILVDAKSNSPAS---LSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQ 346
            :|..||...|...|.||.|:...|.:|   ......||.|.     .|..::|
Yeast   843 NNAGSSPDSATTEKKILDDSSEGSDSSSDNAGLGLSKSEAI-----FHWRDLC------------ 890

  Fly   347 PQHSLQLTFQNLNVLHNERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQ--RHIDSGSV 409
                     .::.:...:|:||::|.|:|.|..:.|:||.||:|||||||||:.:  ..:.:|::
Yeast   891 ---------YDVPIKGGQRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGNI 946

  Fly   410 FLNREPLTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELG 474
            |::.....:.:.|.|||..|:::.....|:||::.::|.||.|.|:...||.|.|:.:::.||:
Yeast   947 FVDGRLRDESFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPSSVSIEEKNRYVEEVIKILEM- 1010

  Fly   475 CCQQTKFGDYL----NRGLSGGEKKRANIACELLTNP-LLMLLDEPTSGLDSHSAISLMKVLKRY 534
              ||  :.|.:    ..||:..::||..|..||...| ||:.||||||||||.:|....:::::.
Yeast  1011 --QQ--YSDAVVGVAGEGLNVEQRKRLTIGVELAARPKLLVFLDEPTSGLDSQTAWDTCQLMRKL 1071

  Fly   535 AQLEQKTIVISVHQPSSQMFHMFDKLLLLHQ-GRTAYFGDV----QNIYRHFEDIGV-TIKPHYN 593
            |...| .|:.::||||:.:...||:||.|.: |:|.||||:    :.:..:||..|. ...|..|
Yeast  1072 ATHGQ-AILCTIHQPSAILMQQFDRLLFLQKGGQTVYFGDLGEGCKTMIDYFESKGAHKCPPDAN 1135

  Fly   594 PADFVLEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIIN 658
            ||:::||.:.:.|                        .||..|
Yeast  1136 PAEWMLEVVGAAP------------------------GSHATQ---------------------- 1154

  Fly   659 NYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPG 723
                        .|..:...|:..:..::|     |.|    .:.|.                ||
Yeast  1155 ------------DYNEVWRNSDEYKAVQEE-----LDW----MEKNL----------------PG 1182

  Fly   724 HSAD---DDWLSYPTSFHTQFCVLSSRNFRE--AKPRML-SKLNWFQTIGLALMAGAIWFQLPRT 782
            .|.:   ::...:..|.:.||.:::.|.|::  ..|..| ||  :..||...:..|..:|:..|:
Yeast  1183 RSKEPTAEEHKPFAASLYYQFKMVTIRLFQQYWRSPDYLWSK--FILTIFNQVFIGFTFFKADRS 1245

  Fly   783 EEFLHDLQGWMFFSQTYWMLF--ALFGALNSFPSEREVV-SKERRSGAYRLSAYYLAKMCAELPL 844
               |..||..|.....|.::|  .|...|.||..:|::. ::||.|..:...|::|:::..|:|.
Yeast  1246 ---LQGLQNQMLSIFMYTVIFNPILQQYLPSFVQQRDLYEARERPSRTFSWLAFFLSQIIVEIPW 1307

  Fly   845 VITLPTVYLMISYPMLGCTSL-----------KLFFLMLIFLLINTIVAQSVGFFI-----GACC 893
            .|...|:...|.|..:|..:.           .||:|.            |:.|::     |...
Yeast  1308 NILAGTIAYCIYYYAVGFYANASAAGQLHERGALFWLF------------SIAFYVYIGSMGLLM 1360

  Fly   894 MDMNVSITLSA-----LYTLATQLFGGYLSSRI-PEGLSWIRYTSMIHYAY-------------- 938
            :..|.....:|     |:|:|....|...:.:: |....::...|.:.|..
Yeast  1361 ISFNEVAETAAHMGTLLFTMALSFCGVMATPKVMPRFWIFMYRVSPLTYMIDALLALGVANVDVK 1425

  Fly   939 -QNMQILEFREGAAIGCG----------------SPSSYEICKQQSTEFIPYEEILKAQNSTSPL 986
             .|.::::|...:...||                .||:.:||.            ..|.::|:..
Yeast  1426 CSNYEMVKFTPPSGTTCGDYMASYIKLAGTGYLSDPSATDICS------------FCAVSTTNAF 1478

  Fly   987 -----------WLNTLILMMFFLVFRCLGYAVLRFL----RCPKK 1016
                       |.|..|    |:.:....|....||    |.|||
Yeast  1479 LATFSSHYYRRWRNYGI----FICYIAFDYIAATFLYWLSRVPKK 1519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	81/229 (35%)
		3a01204	363..1009	CDD:273361	173/731 (24%)
		ABC2_membrane	744..943	CDD:279410	50/241 (21%)
PDR15	NP_010694.1	ABC_trans_N	47..162	CDD:405234
PDR15	NP_010694.1	3a01205	110..1518	CDD:273362	191/822 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I2724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	2	2.000