DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and SNQ2

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_010294.1	Gene:	SNQ2 / 851574	SGDID:	S000002418	Length:	1501	Species:	Saccharomyces cerevisiae

Alignment Length:	600	Identity:	152/600 - (25%)
Similarity:	266/600 - (44%)	Gaps:	177/600 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 ERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHID--SGSVFLNREPLTKKWRRRIGY 426
            :|.:|.:|||:..|..:.|:||.||:||||||:.|: ||::.  :|.:.:|..|:...:.||.||
Yeast   868 KRMLLDNVSGYCIPGTMTALMGESGAGKTTLLNTLA-QRNVGIITGDMLVNGRPIDASFERRTGY 931

  Fly   427 VLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEAL-----------ELGCCQQTK 480
            |.|::|...:||:||::.::|.:|.|:.:|.:|||..|:.|:..|           |:||
Yeast   932 VQQQDIHIAELTVRESLQFSARMRRPQHLPDSEKMDYVEKIIRVLGMEEYAEALVGEVGC----- 991

  Fly   481 FGDYLNRGLSGGEKKRANIACELLTNP-LLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVI 544
                   ||:..::|:.:|..||:..| ||:.||||||||||.|:.:::::|::.::..| :|:.
Yeast   992 -------GLNVEQRKKLSIGVELVAKPDLLLFLDEPTSGLDSQSSWAIIQLLRKLSKAGQ-SILC 1048

  Fly   545 SVHQPSSQMFHMFDKLLLLHQ-GRTAYFGDV----QNIYRHFEDIGV-TIKPHYNPADFVLEQLK 603
            ::||||:.:|..||:||||.: |:|.||||:    ..|..:||..|. ......|||:::||.:.
Yeast  1049 TIHQPSATLFEEFDRLLLLRKGGQTVYFGDIGKNSATILNYFERNGARKCDSSENPAEYILEAIG 1113

  Fly   604 SHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQRSNRH 668
            :......|     ::.|..:||            ||...:.|::     :.|:||:...|.:..
Yeast  1114 AGATASVK-----EDWHEKWLN------------SVEFEQTKEK-----VQDLINDLSKQETKS- 1155

  Fly   669 HHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDDWLSY 733
                                                            ..|..|.        .|
Yeast  1156 ------------------------------------------------EVGDKPS--------KY 1164

  Fly   734 PTSFHTQF---CVLSSRNFREAKPRMLSKLNWFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFF 795
            .||:..||   .:.:|.:|..:...::||:       :.::.|.::.             |:.||
Yeast  1165 ATSYAYQFRYVLIRTSTSFWRSLNYIMSKM-------MLMLVGGLYI-------------GFTFF 1209

  Fly   796 S--QTYW----MLFALF-------GALNSFP----SEREVVS-KERRSGAYRLSAYYLAKMCAEL 842
            :  ::|.    .:||.|       .|:|...    :.||:.. :|.:|..:..|...:.:..:||
Yeast  1210 NVGKSYVGLQNAMFAAFISIILSAPAMNQIQGRAIASRELFEVRESQSNMFHWSLVLITQYLSEL 1274

  Fly   843 PLVITLPTVYLMISYPMLGCTSLKLFFLMLIFLLINTIVAQSVGFFIGACCMDMNVSITLSALYT 907
            |..:...|::.:.||     ..|::||          ..::|..:|:..|.|        ..||.
Yeast  1275 PYHLFFSTIFFVSSY-----FPLRIFF----------EASRSAVYFLNYCIM--------FQLYY 1316

  Fly   908 LATQLFGGYLSSRIP 922
            :...|...|:|..:|
Yeast  1317 VGLGLMILYMSPNLP 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	84/222 (38%)
		3a01204	363..1009	CDD:273361	151/599 (25%)
		ABC2_membrane	744..943	CDD:279410	37/196 (19%)
SNQ2	NP_010294.1	3a01205	103..1480	CDD:273362	151/599 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I2724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	3	2.910