DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and ABCG18

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_191071.1	Gene:	ABCG18 / 824677	AraportID:	AT3G55110	Length:	708	Species:	Arabidopsis thaliana

Alignment Length:	771	Identity:	191/771 - (24%)
Similarity:	327/771 - (42%)	Gaps:	181/771 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 NSHHPHHHSQNQP-QHSLQ-------------LTFQNL--NVLHNER------------QILSDV 371
            :|....:..:|.| ||.|.             |:|.||  ||:...|            .:|.|:
plant    31 DSGRKKYPGENAPTQHILDLAPAAETRSVPFLLSFNNLSYNVVLRRRFDFSRRKTASVKTLLDDI 95

  Fly   372 SGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHIDS--GSVFLNREPLTKKWRRRI--GYVLQEEI 432
            :|.....|:||::|.||:||:||:|.|:|:...||  |:|.||.|.:.:....::  .||:|:::
plant    96 TGEARDGEILAVLGGSGAGKSTLIDALAGRVAEDSLKGTVTLNGEKVLQSRLLKVISAYVMQDDL 160

  Fly   433 FFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRA 497
            .||.||::||:::.:..|||.|:|:::||.:|:.:::.|.|.....|..||..:||:||||::|.
plant   161 LFPMLTVKETLMFASEFRLPRSLPKSKKMERVETLIDQLGLRNAADTVIGDEGHRGVSGGERRRV 225

  Fly   498 NIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLL 562
            :|..:::.:|:|:.||||||||||.:|..:::||||.|| ....:::|:||||:::..:.|:|::
plant   226 SIGIDIIHDPILLFLDEPTSGLDSTNAFMVVQVLKRIAQ-SGSVVIMSIHQPSARIIGLLDRLII 289

  Fly   563 LHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESHGNYLNRN 627
            |..|::.:.|...::...|...|..|....|..:|.|:.      |||
plant   290 LSHGKSVFNGSPVSLPSFFSSFGRPIPEKENITEFALDV------IRE----------------- 331

  Fly   628 CITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCR--VEEDEEA 690
                                                           |..:|.|.|  ||.:|:.
plant   332 -----------------------------------------------LEGSSEGTRDLVEFNEKW 349

  Fly   691 AQHLVWCAADSQSNFS-------SCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSSRN 748
            .|:.. ..|.:||..|       |.:.....|.|:|:.|        :|..|       |.|..|
plant   350 QQNQT-ARATTQSRVSLKEAIAASVSRGKLVSGSSGANP--------ISMET-------VSSYAN 398

  Fly   749 FREAKPRMLSK---LNWFQT-------IGLALMAG----AIWFQLPRTEEFLHDLQGWMFFSQTY 799
            ...|:..:|:|   .||.:|       ||..::.|    .::::|..|.....:..|:..|..:
plant   399 PPLAETFILAKRYIKNWIRTPELIGMRIGTVMVTGLLLATVYWRLDNTPRGAQERMGFFAFGMS- 462

  Fly   800 WMLFALFGALNSFPSEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCT- 863
            .|.:.....:..|..||.:..:|....|||.|:|.::.....||.::.|...:...::..:|.:
plant   463 TMFYCCADNIPVFIQERYIFLRETTHNAYRTSSYVISHALVSLPQLLALSIAFAATTFWTVGLSG 527

  Fly   864 SLKLFFLMLIFLLINTIVAQSVGFFIGACCMDMNVSITLSALYTLATQLFGGYL--SSRIPEGLS 926
            .|:.||...:.:........|:..||.....::.:|..::..|.....|.||:.  ..|||....
plant   528 GLESFFYYCLIIYAAFWSGSSIVTFISGLIPNVMMSYMVTIAYLSYCLLLGGFYINRDRIPLYWI 592

  Fly   927 WIRYTSMIHYAYQNMQILEFRE-------GAAI-----------------------GCGSPSSYE 961
            |..|.|::.|.|:.:.|.||.:       |..:                       ..|:..:..
plant   593 WFHYISLLKYPYEAVLINEFDDPSRCFVKGVQVFDGTLLAEVSHVMKVKLLDTLSGSLGTKITES 657

  Fly   962 ICKQQSTEFIPYEEILKAQNSTSPLWLNTLILMMFFLVFRCLGYAVLRFLRCPKKT 1017
            .|.:...:.:..:.|.:. :....||    |.:.:.|.||.|.|..|.|....|:|
plant   658 TCLRTGPDLLMQQGITQL-SKWDCLW----ITLAWGLFFRILFYLSLLFGSKNKRT 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	89/252 (35%)
		3a01204	363..1009	CDD:273361	175/717 (24%)
		ABC2_membrane	744..943	CDD:279410	48/215 (22%)
ABCG18	NP_191071.1	3a01204	57..707	CDD:273361	183/742 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720