DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E23 and ABCG20

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_190919.1	Gene:	ABCG20 / 824519	AraportID:	AT3G53510	Length:	739	Species:	Arabidopsis thaliana

Alignment Length:	829	Identity:	202/829 - (24%)
Similarity:	342/829 - (41%)	Gaps:	198/829 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 TAATSVASSD--SSASSSASSTSSSSSSSTSSEFTHTSQTTIPSTDNLTSSNGLANIGKSILVDA 304
            ||..||..::  .|........|.:...:.:|.|    .:::||:                  ..
plant    38 TARVSVTLAELLMSVEDEGDDQSRAMDIAVASNF----WSSVPSS------------------RV 80

  Fly   305 KSNSPASLSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLHNERQILS 369
            .|:||..||:          :...:::.|.....|.....|.|       |...::..|.:.:|:
plant    81 PSSSPFVLSF----------KDLTYSVKIKKKFKPFPCCGNSP-------FDGNDMEMNTKVLLN 128

  Fly   370 DVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHIDS--GSVFLNREPLTKKWRRRI-GYVLQEE 431
            .:||.....|::|::|.|||||:||:|.|:.:...:|  |.:.||.|.|.....:.| .||:|::
plant   129 GISGEAREGEMMAVLGASGSGKSTLIDALANRISKESLRGDITLNGEVLESSLHKVISAYVMQDD 193

  Fly   432 IFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKR 496
            :.||.||:.||::::|..|||.|:.:.:|..:|..:::.|.|....:|..||..:||:||||::|
plant   194 LLFPMLTVEETLMFSAEFRLPSSLSKKKKKARVQALIDQLGLRNAAKTVIGDEGHRGVSGGERRR 258

  Fly   497 ANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLL 561
            .:|..:::.:|:::.||||||||||.||..::|||:|.|| ....:::|:||||.::..:.|||:
plant   259 VSIGTDIIHDPIILFLDEPTSGLDSTSAYMVVKVLQRIAQ-SGSIVIMSIHQPSYRILGLLDKLI 322

  Fly   562 LLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLE---QLKSHPDIREKLFIAAKESHGNY 623
            .|.:|.|.|.|...::.:.|.:.|..|..:.|..:|.|:   :|:..|:..:.|.    |.|..:
plant   323 FLSRGNTVYSGSPTHLPQFFSEFGHPIPENENKPEFALDLIRELEDSPEGTKSLV----EFHKQW 383

  Fly   624 LNRNCITSSHHN-------QVSVSGAKGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNG 681
            ..:...:.|..|       .:|.|.::||
plant   384 RAKQTSSQSRRNTNVSLKDAISASISRGK------------------------------------ 412

  Fly   682 CRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSS 746
                        ||..|.:.:|:|.:.|:                         .|.|:..|:..
plant   413 ------------LVSGATNLRSSFQTFAN-------------------------PFWTEMLVIGK 440

  Fly   747 RNFREAK--PRMLSKLNWFQTIGLALMAG----AIWFQLPRTEEFLHDLQGWMFF--SQTYWMLF 803
            |:...::  |.:..     ..:|..|:.|    .|:::|..:...:.:..|:..|  |.|:   :
plant   441 RSILNSRRQPELFG-----IRLGAVLVTGMILATIFWKLDNSPRGIQERLGFFAFAMSTTF---Y 497

  Fly   804 ALFGALNSFPSEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCTSLKLF 868
            ....|:..|..||.:..:|....|||.|:|.||.....:|.:|.|...:...::..:|.......
plant   498 TCAEAIPVFLQERYIFMRETAYNAYRRSSYVLAHTIISIPALIILSAAFAASTFSAVGLAGGSEG 562

  Fly   869 FLMLIFLLINTIVAQS--VGFFIGA---CCMDMNVSITLSALYTLATQLFGGYLSS--RIPEGLS 926
            ||...|.::....|.|  |.|..|.   ..:...|.:.:.|.:.    ||.|:..|  |||....
plant   563 FLFFFFTILTAFWAGSSFVTFLSGVVSHVMIGFTVVVAILAYFL----LFSGFFISRDRIPLYWI 623

  Fly   927 WIRYTSMIHYAYQNMQILEFRE-------GAAIGCGSP-------SSYEICKQQS---------- 967
            |..|.|::.|.|:.:...||.:       |..:...||       ....:.|..|
plant   624 WFHYLSLVKYPYEGVLQNEFEDPTKCFVRGIQMFDNSPLGQVPTAVKISLLKSMSGVLGINVTAE 688

  Fly   968 ---TEFIPYEEILKAQNST-----SPLWLNTLILMMFFLVFRCLGYAVL 1008
               |..|   :|||.|..|     :.||:.  :...||  ||.|.|..|
plant   689 TCVTTGI---DILKQQGITEISKWNCLWIT--VAWGFF--FRVLFYFTL 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	84/224 (38%)
		3a01204	363..1009	CDD:273361	182/706 (26%)
		ABC2_membrane	744..943	CDD:279410	49/213 (23%)
ABCG20	NP_190919.1	P-loop_NTPase	119..333	CDD:304359	83/214 (39%)
		3a01204	120..738	CDD:273361	182/708 (26%)
		ABC2_membrane	438..641	CDD:279410	49/214 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720