DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and ABCG26

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_187928.2	Gene:	ABCG26 / 820512	AraportID:	AT3G13220	Length:	685	Species:	Arabidopsis thaliana

Alignment Length:	783	Identity:	227/783 - (28%)
Similarity:	367/783 - (46%)	Gaps:	151/783 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 SSTSSEFTHTSQTTIPSTDNLTSSNGLAN-------------IGKSILVDAK-------SNSPAS 311
            |:...|..|..|        :|.|||:.:             ....|.:|.:       .::|..
plant     6 STEEVEENHVMQ--------ITGSNGIVHNMEFMPQAYLRNQYSSEIDIDEEFVSTYPLEDAPLP 62

  Fly   312 LSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLHNE------RQILSD 370
            :...||..          ...:.|||        ....:|..|..:..|.|..      :.||..
plant    63 IFLKFEDV----------EYKVRNSH--------ASSANLVKTMVSKVVTHTNPDPDGYKHILKG 109

  Fly   371 VSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHIDS--GSVFLNREPLTKKWRRRIGYVLQEEIF 433
            ::|...|.|:||:||||||||||||..:.| |..|:  |.:..|..|.:...:||||:|.|:::.
plant   110 ITGSTGPGEILALMGPSGSGKTTLLKIMGG-RLTDNVKGKLTYNDIPYSPSVKRRIGFVTQDDVL 173

  Fly   434 FPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRAN 498
            .||||:.||:.:.|.||||.||.:.:|..:::.|::.|.|..|::|:.|....:|:||||:|||:
plant   174 LPQLTVEETLAFAAFLRLPSSMSKEQKYAKIEMIIKELGLERCRRTRVGGGFVKGISGGERKRAS 238

  Fly   499 IACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLL 563
            ||.|:|.:|.|:|||||||||||.||..|:.:|:..|: ..:|::.::|||||:||||||||||:
plant   239 IAYEILVDPSLLLLDEPTSGLDSTSATKLLHILQGVAK-AGRTVITTIHQPSSRMFHMFDKLLLI 302

  Fly   564 HQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLE----QLK--SHPDIREKLFIAAKESHGN 622
            .:|..|::|..:....:|..:.:..:...|||:|:|:    |:.  |.||    ..:|||.:
plant   303 SEGHPAFYGKARESMEYFSSLRILPEIAMNPAEFLLDLATGQVSDISLPD----ELLAAKTA--- 360

  Fly   623 YLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQR--SNRHHHQYENLHHTSNGCRVE 685
                                    |.||   ::::..|..||  ::....:.|..|
plant   361 ------------------------QPDS---EEVLLKYLKQRYKTDLEPKEKEENH--------- 389

  Fly   686 EDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSSRNFR 750
            .:.:|.:||....                          ....||   ..|:..||.:||.|.||
plant   390 RNRKAPEHLQIAI--------------------------QVKKDW---TLSWWDQFLILSRRTFR 425

  Fly   751 EAKPRMLSKLNWFQTIGLALMAGAIWFQLPR-TEEFLHDLQGWMFFSQTYWMLFALFGALNSFPS 814
            |.:.....||...|::|:|::.|.:|::... ||..|.|..|.||:...:|...:||||:..||.
plant   426 ERRRDYFDKLRLVQSLGVAVVLGLLWWKSKTDTEAHLRDQVGLMFYICIFWTSSSLFGAVYVFPF 490

  Fly   815 EREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCT-SLKLFFLMLIFLLIN 878
            |:..:.|||::..||||.||:.....::...:..||.:::|.|.|.... ::..|...::.:|:.
plant   491 EKIYLVKERKAEMYRLSVYYVCSTLCDMVAHVLYPTFFMIIVYFMAEFNRNIPCFLFTVLTILLI 555

  Fly   879 TIVAQSVGFFIGACCMDMNVSITLSALYTLATQLFGGYLSSRIPEGLSWIRYTSMIHYAYQNMQI 943
            .|.:|..|.|:||..:.:..:..:::|..:...|.|||....||:.:.|::|.|.:||.::.:..
plant   556 AITSQGAGEFLGASVLSIKRAGMIASLVLMLFLLTGGYYVQHIPKFMQWLKYLSFMHYGFRLLLK 620

  Fly   944 LEFREGAAIGCGSPSSYEICK--QQSTEFIPYEEILKAQNSTSPLWLNTLILMMFFLVFRCLGYA 1006
            :::.......|||...   |:  |.|:.|    :.:........||:  |:.|.|  .:|...|.
plant   621 VQYSADQLFECGSKGG---CRTLQSSSSF----DTINLNGGLQELWV--LLAMAF--GYRLCAYF 674

  Fly  1007 VLR 1009
            .||
plant   675 CLR 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	103/229 (45%)
		3a01204	363..1009	CDD:273361	205/665 (31%)
		ABC2_membrane	744..943	CDD:279410	62/200 (31%)
ABCG26	NP_187928.2	PLN03211	62..678	CDD:215634	216/719 (30%)
		ABCG_EPDR	93..311	CDD:213180	101/219 (46%)
		ABC2_membrane	435..621	CDD:279410	55/185 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	148	1.000	Domainoid score	I1436
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	371	1.000	Inparanoid score	I563
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm2959
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	O	PTHR48041
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.960