DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and ABCG1

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_181467.1	Gene:	ABCG1 / 818520	AraportID:	AT2G39350	Length:	740	Species:	Arabidopsis thaliana

Alignment Length:	764	Identity:	189/764 - (24%)
Similarity:	321/764 - (42%)	Gaps:	172/764 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 PHHHSQNQPQHS-------LQLTFQNL-------------NVLHNER---------------QIL 368
            |.|.|.||..:.       ..|:|.||             |:....|               .:|
plant    46 PVHESLNQDYNDGYMRTVPFVLSFDNLTYNVSVRPKLDFRNLFPRRRTEDPEIAQTARPKTKTLL 110

  Fly   369 SDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHIDS--GSVFLNREPLTKKWRRRI-GYVLQE 430
            :::||.....|::|::|.|||||:||:|.|:.:....|  |:|.||.|.|..:..:.| .||:|:
plant   111 NNISGETRDGEIMAVLGASGSGKSTLIDALANRIAKGSLKGTVKLNGETLQSRMLKVISAYVMQD 175

  Fly   431 EIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKK 495
            ::.||.||:.||:::.|..|||.|:|:::|..:|..:::.|.:....:|..||..:||:||||::
plant   176 DLLFPMLTVEETLMFAAEFRLPRSLPKSKKKLRVQALIDQLGIRNAAKTIIGDEGHRGISGGERR 240

  Fly   496 RANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKL 560
            |.:|..:::.:|:|:.||||||||||.||..::|||||.|| ....:::|:||||.::..:.|:|
plant   241 RVSIGIDIIHDPILLFLDEPTSGLDSTSAFMVVKVLKRIAQ-SGSIVIMSIHQPSHRVLGLLDRL 304

  Fly   561 LLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESHGNYLN 625
            :.|.:|.|.|.|...::.|.|.:.|..|..:.|..:|.|:.:              :|..|
plant   305 IFLSRGHTVYSGSPASLPRFFTEFGSPIPENENRTEFALDLI--------------RELEG---- 351

  Fly   626 RNCITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQRSNRHHHQ---------YENLHHTSNG 681
                        |..|.:|       ||:  .|..:.:...:.:.|         |.||
plant   352 ------------SAGGTRG-------LIE--FNKKWQEMKKQSNRQPPLTPPSSPYPNL------ 389

  Fly   682 CRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSS 746
                ..:||.     .|:.|:....|...|..|.       |.:.:...|:.|...:..:..:.:
plant   390 ----TLKEAI-----AASISRGKLVSGGESVAHG-------GATTNTTTLAVPAFANPMWIEIKT 438

  Fly   747 RNFREAKPRMLSKLNWFQTIGLAL--------MAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLF 803
            .    :|..||:.....:..|:.:        :...::::|..:.:.:.:..|:..|:.: .|.:
plant   439 L----SKRSMLNSRRQPELFGIRIASVVITGFILATVFWRLDNSPKGVQERLGFFAFAMS-TMFY 498

  Fly   804 ALFGALNSFPSEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPML----GCTS 864
            ....||..|..||.:..:|....|||.|:|.|:......|.:|.|...:...:|..:    |.|.
plant   499 TCADALPVFLQERYIFMRETAYNAYRRSSYVLSHAIVSFPSLIFLSVAFAATTYWAVGLDGGLTG 563

  Fly   865 LKLFFLMLIFLLINTIVAQSVGFFIGACCMDMNVSITLSAL--YTLATQ------LFGGYL--SS 919
            | ||:.::|.          ..|:.|:..:.....:..|.:  ||:...      ||.|:.  .:
plant   564 L-LFYCLIIL----------ASFWSGSSFVTFLSGVVPSVMLGYTIVVAILAYFLLFSGFFINRN 617

  Fly   920 RIPEGLSWIRYTSMIHYAYQNMQILEFRE-------GAAIGCGSP-----------------SSY 960
            |||:...|..|.|::.|.|:.:...||.:       |..|...:|                 .|.
plant   618 RIPDYWIWFHYMSLVKYPYEAVLQNEFSDATKCFVRGVQIFDNTPLGELPEVMKLKLLGTVSKSL 682

  Fly   961 EICKQQSTEFIPYEEILKAQNSTS-PLWLNTLILMMFFLVFRCLGYAVL 1008
            .:....:|......:||:.|.... ..|....|.:.|...||.|.|..|
plant   683 GVTISSTTCLTTGSDILRQQGVVQLSKWNCLFITVAFGFFFRILFYFTL 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	90/259 (35%)
		3a01204	363..1009	CDD:273361	179/720 (25%)
		ABC2_membrane	744..943	CDD:279410	46/220 (21%)
ABCG1	NP_181467.1	3a01204	106..739	CDD:273361	178/704 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720