DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E23 and abcg4b

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_001104682.1	Gene:	abcg4b / 794238	ZFINID:	ZDB-GENE-080215-10	Length:	644	Species:	Danio rerio

Alignment Length:	756	Identity:	207/756 - (27%)
Similarity:	336/756 - (44%)	Gaps:	171/756 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 KSNSPASLSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQPQH-------------------- 349
            |::.|.|:|...|:|             :||       ..:|||.
Zfish     4 KTSDPGSVSIGMEES-------------LCN-------GGSQPQEAPLLTHLKKVENHITEAQRF 48

  Fly   350 -------SLQLTFQNLNVLHNE---------RQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCL 398
                   :::|.|:.|.....|         :.:|..:||..|..|::.||||||:||:||::.|
Zfish    49 SHLPKRTTVELEFKELCYTIREGPWWKKQGYKALLKCLSGKFSSRELIGIMGPSGAGKSTLMNIL 113

  Fly   399 SGQRHID-SGSVFLN---REPLTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAE 459
            :|.|... :|.:.:|   |:|.|  :|:...|::||:...|.|:::|.::.:|.|:|.||  ...
Zfish   114 AGYRETGMTGQILVNGKLRDPRT--FRKMSCYIMQEDKLLPHLSVQEAMMVSANLKLNES--SEV 174

  Fly   460 KMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSA 524
            |...:..||.||.|..|..|:     ...||||:.||..||.||:.||.:|..|||||||||.|.
Zfish   175 KKELIKEILTALGLHECVHTR-----TVSLSGGQCKRLAIALELVNNPPVMFFDEPTSGLDSASC 234

  Fly   525 ISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIK 589
            ..::.::|..|| ..:||:.::||||:::|.|||||.:|.||:..|.|.|..:..:...:|:...
Zfish   235 FQVVSLMKSLAQ-GGRTIICTIHQPSAKLFEMFDKLYILSQGQCIYKGSVPYLIPYLRGLGLHCP 298

  Fly   590 PHYNPADFVLEQLK-SHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILI 653
            .::|||||::|... .:.|:...||.|                       |.|..
Zfish   299 TYHNPADFIIEVASGEYGDLNPVLFEA-----------------------VQGGM---------- 330

  Fly   654 DDIINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSA 718
                                        |.:||.         |....::..:|||:      ..
Zfish   331 ----------------------------CALEEK---------CNCIDKTTVTSCAA------KC 352

  Fly   719 GSGPGHSADDDWLSYPTSFHTQFCVLSSRNF-REAKPRMLSKLNWFQTIGLALMAGAIWFQLPRT 782
            ...|||....   ::.||..||||:|..|.| ...:.::|:.|.....|.:.::.|.::..:...
Zfish   353 VKDPGHVESH---TFATSSLTQFCILFKRTFITICRDQVLTHLRLMSHISIGVLIGLLYLNIGND 414

  Fly   783 EEFLHDLQGWMFFSQTYWMLFALFGALN----SFPSEREVVSKERRSGAYRLSAYYLAKMCAELP 843
            ...:.:..|::|||    |||.:||||.    :||.|..|..:|..:..|.|.||||||..|::|
Zfish   415 ASKVFNNTGFLFFS----MLFLMFGALMPTVLTFPLEMAVFLREHLNYWYSLKAYYLAKTMADIP 475

  Fly   844 LVITLPTVYLMISYPMLGCTSLKLFFLMLIFLLINT-IVAQSVGFFIGACCMDMNVSITLSALYT 907
            ..:..|.:|..|.|.|.........:|:.:.|.|.| :||||:|..:||....:.|:..:..:..
Zfish   476 FQVLCPIMYCSIVYWMTEQPPEASRYLLFLALSICTALVAQSLGLLVGAASTSLQVATFVGPVTG 540

  Fly   908 LATQLFGGYLSS--RIPEGLSWIRYTSMIHYAYQNMQILEFREGAAIGCGSPSSYEICKQQSTEF 970
            :...||.|:..:  .|||.|.|..|.|.:.|.::.:.:..:        |...:...|..:..:|
Zfish   541 IPVLLFSGFFVNFDTIPEYLQWSSYVSYVRYGFEEVILSIY--------GMNRTERECPGRVCKF 597

  Fly   971 IPYEEILKAQN-STSPLWLNTLILMMFFLVFRCLGYAVLRF 1010
            ...||:|:..: ..:.|:::.::|.:||::.|...|.|||:
Zfish   598 QRPEEVLQLLDVEDAKLYMDFIVLGIFFVILRLATYVVLRY 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	89/234 (38%)
		3a01204	363..1009	CDD:273361	191/668 (29%)
		ABC2_membrane	744..943	CDD:279410	61/206 (30%)
abcg4b	NP_001104682.1	3a01204	42..644	CDD:273361	196/698 (28%)
		ABCG_EPDR	57..281	CDD:213180	89/233 (38%)
		ABC2_membrane	375..574	CDD:279410	61/202 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.710