Protein Alignment E23 and Abcg8

DIOPT Version :10

• Sequence 1: NP_524648.3
• Gene: E23 / 43895
• FlyBaseID: FBgn0020445
• Length: 1017
• Species: Drosophila melanogaster
• Sequence 2: NP_080456.1
• Gene: Abcg8 / 67470
• MGIID: 1914720
• Length: 673
• Species: Mus musculus
• Alignment Length: 806
• Identity: 199/806 - (24%)
• Similarity: 330/806 - (40%)
• Gaps: 206/806 - (25%)

  Fly   254 ASSSASSTSSSSSSSTSSEFTHTSQTTIPSTDNLTSSNGLANIGKSILVDAKSNSPASLSYHFEK 318
            ||.....:..||.|..|..||::.|:......:||..           ||..|..|     .||:
Mouse    20 ASQGLQDSLFSSESDNSLYFTYSGQSNTLEVRDLTYQ-----------VDIASQVP-----WFEQ 68

  Fly   319 SAAANQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLHNERQILSDVSGFVSPCEVLAI 383
            .|......:.|:                .|.|.:|..:||             |..|...::|||
Mouse    69 LAQFKIPWRSHS----------------SQDSCELGIRNL-------------SFKVRSGQMLAI 104

  Fly   384 MGPSGSGKTTLLDCLSGQRH---IDSGSVFLNREPLTKKW-RRRIGYVLQEEIFFPQLTLRETVV 444
            :|.||.|:.:|||.::|:.|   :.||.:::|.:|.|.:. |:.:.:|.|.:...|.||:|||:.
Mouse   105 IGSSGCGRASLLDVITGRGHGGKMKSGQIWINGQPSTPQLVRKCVAHVRQHDQLLPNLTVRETLA 169

  Fly   445 YTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLL 509
            :.|.:|||.:..:|::.::|:.::..|.|..|..|:.|:...||:||||::|.:|..:||.||.:
Mouse   170 FIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGI 234

  Fly   510 MLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDV 574
            ::||||||||||.:|.:|:..|.|.|: ..:.::||:|||.|.:|.:||.:||:..|...|.|..
Mouse   235 LILDEPTSGLDSFTAHNLVTTLSRLAK-GNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAA 298

  Fly   575 QNIYRHFEDIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSV 639
            |.:.::|..||.....:.|||||                         |::...|......:...
Mouse   299 QQMVQYFTSIGHPCPRYSNPADF-------------------------YVDLTSIDRRSKEREVA 338

  Fly   640 SGAKGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSN 704
            :..|.:..|...|                                 |..:.....:|.|...:.|
Mouse   339 TVEKAQSLAALFL---------------------------------EKVQGFDDFLWKAEAKELN 370

  Fly   705 FSS-------CASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVL----SSRNFREAKPRMLS 758
            .|:       ...:||.  :|...||             ...||..|    .|.:||:. |.:|
Mouse   371 TSTHTVSLTLTQDTDCG--TAVELPG-------------MIEQFSTLIRRQISNDFRDL-PTLL- 418

  Fly   759 KLNWFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSF----------P 813
             ::..:...::|:.|.:::.        |..: .:.|..|..:|| :.|||..|          .
Mouse   419 -IHGSEACLMSLIIGFLYYG--------HGAK-QLSFMDTAALLF-MIGALIPFNVILDVVSKCH 472

  Fly   814 SEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCTSLK----LFFLMLIF 874
            |||.::..|...|.|....|:.||:..|||.......:|.|   |:...|:|:    ||  :|.|
Mouse   473 SERSMLYYELEDGLYTAGPYFFAKILGELPEHCAYVIIYAM---PIYWLTNLRPVPELF--LLHF 532

  Fly   875 LLINTIVAQSVGFFIGACCMDMNV------------SITLSALYTLATQLFGGYLSSR-----IP 922
            ||:..:|         .||..|.:            |...:|||. :..|..|::.:.     :|
Mouse   533 LLVWLVV---------FCCRTMALAASAMLPTFHMSSFFCNALYN-SFYLTAGFMINLDNLWIVP 587

  Fly   923 EGLSWIRYTSMIHYAYQNMQILEFREGAAIGCGSPSSYEICKQQSTEFIPYEEILKAQNSTS-PL 986
               :||...|.:.:.:..:..::|.       |...:.:|  ...|..|..:.::.|.:..| ||
Mouse   588 ---AWISKLSFLRWCFSGLMQIQFN-------GHLYTTQI--GNFTFSILGDTMISAMDLNSHPL 640

  Fly   987 WLNTLILMMFFLVFRCLGYAVLRFLR 1012
            :...||::.....|..|.|..|:.::
Mouse   641 YAIYLIVIGISYGFLFLYYLSLKLIK 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	3a01204	363..1009	CDD:273361	174/692 (25%)
Abcg8	NP_080456.1	ABCG_White	71..296	CDD:213201	85/254 (33%)
		3a01204	89..664	CDD:273361	177/701 (25%)