Protein Alignment E23 and ABCG8

DIOPT Version :10

• Sequence 1: NP_524648.3
• Gene: E23 / 43895
• FlyBaseID: FBgn0020445
• Length: 1017
• Species: Drosophila melanogaster
• Sequence 2: NP_071882.1
• Gene: ABCG8 / 64241
• HGNCID: 13887
• Length: 673
• Species: Homo sapiens
• Alignment Length: 797
• Identity: 211/797 - (26%)
• Similarity: 327/797 - (41%)
• Gaps: 207/797 - (25%)

  Fly   264 SSSSSTSSEFTHTSQTTIPSTDNLTSSNGLANIGKSILVDAKSNSPASLSYHFEKSAAANQQKQH 328
            ||.|..|..||::.|   |:|..:...|        ..||..|..|     .||:.|   |.|..
Human    29 SSESDNSLYFTYSGQ---PNTLEVRDLN--------YQVDLASQVP-----WFEQLA---QFKMP 74

  Fly   329 HNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLHNERQILSDVSGFVSPCEVLAIMGPSGSGKTT 393
            .....|             |:|.:|..|||             |..|...::|||:|.||.|:.:
Human    75 WTSPSC-------------QNSCELGIQNL-------------SFKVRSGQMLAIIGSSGCGRAS 113

  Fly   394 LLDCLSGQRH---IDSGSVFLNREPLTKKW-RRRIGYVLQEEIFFPQLTLRETVVYTALLRLPES 454
            |||.::|:.|   |.||.:::|.:|.:.:. |:.:.:|.|.....|.||:|||:.:.|.:|||.:
Human   114 LLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRT 178

  Fly   455 MPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGL 519
            ..:|::.::|:.::..|.|..|..|:.|:...|||||||::|.:|..:||.||.:::||||||||
Human   179 FSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGL 243

  Fly   520 DSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDI 584
            ||.:|.:|:|.|.|.|: ..:.::||:|||.|.:|.:||.:||:..|...|.|..|::.::|..|
Human   244 DSFTAHNLVKTLSRLAK-GNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAI 307

  Fly   585 GVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQAD 649
            |.....:.|||||                         |::...|......|...:..|.:..|.
Human   308 GYPCPRYSNPADF-------------------------YVDLTSIDRRSREQELATREKAQSLAA 347

  Fly   650 SIL-----IDDIINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCA 709
            ..|     :||.:                                      |.|.....:..:|.
Human   348 LFLEKVRDLDDFL--------------------------------------WKAETKDLDEDTCV 374

  Fly   710 SSDCHSYSAGSGPGHSADDDWLSYPTSFH---TQFCVLSSRNFREAKPRMLSKLNWFQTIGLALM 771
            .|..          ...|.:.|..||...   .||..|..|...          |.|:.:...|:
Human   375 ESSV----------TPLDTNCLPSPTKMPGAVQQFTTLIRRQIS----------NDFRDLPTLLI 419

  Fly   772 AGAIWFQLPRTEEFLHDLQG--WMFFSQTYWMLFALFGALNSFP----------SEREVVSKERR 824
            .||....:..|..||:...|  .:.|..|..:|| :.|||..|.          |||.::..|..
Human   420 HGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLF-MIGALIPFNVILDVISKCYSERAMLYYELE 483

  Fly   825 SGAYRLSAYYLAKMCAELP------LVITLPTVYLMISYPMLGCTSLKLFFLMLIFLLINTIVAQ 883
            .|.|....|:.||:..|||      ::..:||.:|....|     .|:.|  :|.|||:..:|
Human   484 DGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRP-----GLQPF--LLHFLLVWLVV-- 539

  Fly   884 SVGFFIGACCMDMNV------------SITLSALYTLATQLFGGY---LSS--RIPEGLSWIRYT 931
                   .||..|.:            |...:|||. :..|.||:   |||  .:|   :||...
Human   540 -------FCCRIMALAAAALLPTFHMASFFSNALYN-SFYLAGGFMINLSSLWTVP---AWISKV 593

  Fly   932 SMIHYAYQNMQILEFREGAAIGCGSPSSYEICKQQSTEFIPYEEILKAQNSTS-PLWLNTLILMM 995
            |.:.:.::.:..::|         |..:|::.....|..:..::||......| ||:...||::.
Human   594 SFLRWCFEGLMKIQF---------SRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIG 649

  Fly   996 FFLVFRCLGYAVLRFLR 1012
            ....|..|.|..|||::
Human   650 LSGGFMVLYYVSLRFIK 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	3a01204	363..1009	CDD:273361	182/693 (26%)
ABCG8	NP_071882.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		ABCG_White	60..295	CDD:213201	95/269 (35%)
		3a01204	88..663	CDD:273361	185/701 (26%)