DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E23 and ABCD4

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_005041.1	Gene:	ABCD4 / 5826	HGNCID:	68	Length:	606	Species:	Homo sapiens

Alignment Length:	216	Identity:	60/216 - (27%)
Similarity:	85/216 - (39%)	Gaps:	51/216 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 NERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHIDSGSV------------FLNREP 415
            :::.::.|:|..:|..:.|.|.|.:|:|||:||..|.|......|||            ||.::|
Human   399 SDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKP 463

  Fly   416 LTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALEL------- 473
                             ||...||||.|:|......|:|....:     :.||..|||
Human   464 -----------------FFTDGTLREQVIYPLKEVYPDSGSADD-----ERILRFLELAGLSNLV 506

  Fly   474 ----GCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRY 534
                |..||..:..|  ..||.||.:|.:.|......|...:|||.||.|..    .:...|.|.
Human   507 ARTEGLDQQVDWNWY--DVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTE----EVESELYRI 565

  Fly   535 AQLEQKTIVISVHQPSSQMFH 555
            .|....|.:...|:.|.:.||
Human   566 GQQLGMTFISVGHRQSLEKFH 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	60/216 (28%)
		3a01204	363..1009	CDD:273361	60/216 (28%)
		ABC2_membrane	744..943	CDD:279410
ABCD4	NP_005041.1	3a01203	9..600	CDD:273360	60/216 (28%)
		ABC_membrane_2	16..294	CDD:284003
		ABCD_peroxisomal_ALDP	387..598	CDD:213190	60/216 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3107
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950