DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and Abcg3

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	XP_038948191.1	Gene:	Abcg3 / 498327	RGDID:	1565568	Length:	703	Species:	Rattus norvegicus

Alignment Length:	777	Identity:	187/777 - (24%)
Similarity:	327/777 - (42%)	Gaps:	146/777 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 SQTTIPSTDNLTSSNGLA-------NIGKSILVDAKSNSPASLSYHFEKSAAANQQKQHHNINIC 334
            |:|:||...  .|||.::       || |..|::.....|..:|.:.:.......:::|.::...
  Rat     7 SKTSIPWKG--VSSNCVSIHRSTYKNI-KPTLINPLKEEPLKMSSNNDPIVIPMAERRHSDLPET 68

  Fly   335 NSHHPHHHSQNQPQHSLQLTFQNLNV---------LHNERQI---LSDVSGFVSPCEVLAIMGPS 387
            |:..|...::     ...|:|.|::.         |..:.::   ||.:||.:.| .:.|||||.
  Rat    69 NTSDPETLTK-----EAVLSFHNISYRETVQSGFPLRQQTRVIERLSSISGIMGP-GLNAIMGPQ 127

  Fly   388 GSGKTTLLDCLSGQRHID--SGSVFLNREPLTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLR 450
            ...::.|||.|:.:|...  ||.:.:|.:|....::...|||.|.::....:|:|:.:.::|.||
  Rat   128 DGSRSLLLDVLAARRDPSGLSGDILVNGKPRPANFKCTSGYVPQNDVVMHTVTVRDNLEFSAALR 192

  Fly   451 LPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEP 515
            ||.::.|.||.|:::.:||.|.|...|.||       ..|...:||.:||.||:....::.||:|
  Rat   193 LPMTITRDEKRRRINEVLELLHLDKEQNTK-------PRSKELRKRTSIAVELIAEHPILFLDDP 250

  Fly   516 TSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRH 580
            |:.||..:...::.||:|.: ::.|||:.|::||...:|..||.|.|:..|:..:.|..::...:
  Rat   251 TTDLDLTTTTYVISVLRRMS-MKGKTIIFSINQPQYSIFRFFDSLTLVASGKLMFHGPARDALEY 314

  Fly   581 FEDIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESH--GNYLNRNCITSSHHNQVSVSGAK 643
            |...|...:.|.|||||.|:.      |...|....::.|  |||
  Rat   315 FTSAGYQYESHNNPADFFLDV------INGGLCDTEEDGHEAGNY-------------------- 353

  Fly   644 GKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCRVEE-------DEEAAQHLVWCAADS 701
                      :::....|.......:...::..|:....|:::       |..:|..
  Rat   354 ----------EELFERKYQATKKLANMYAQSRLHSDTRARLDQLLGQQQLDRNSAVE-------- 400

  Fly   702 QSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSSRNFR-----EAKPRMLSKLN 761
                ::|.:...|...            |::|.          |.:|.|     .||..::
  Rat   401 ----TTCVTPFWHQLM------------WITYQ----------SFKNIRGFLLVTAKQAVI---- 435

  Fly   762 WFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSFPSEREVVSKERRSG 826
               |..||.:.| |.||:.:.......::..:.:..|.:.......|...|..:|:....|..||
  Rat   436 ---TATLAALVG-IAFQILKNGCIEVYIRAGLLYLLTIFQCITSVSAGELFVIDRDRFLHEHTSG 496

  Fly   827 AYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGC-TSLKLFFLMLIFLLINTIVAQSVGFFIG 890
            .||:|:|:..|:.|||.....||:..::|:|.:.|. ||:..||.||..:::....|.|:...||
  Rat   497 YYRVSSYFFGKLLAELIPRRLLPSTIVLITYFIAGVKTSMSSFFAMLFTVMMLAYSASSLPLSIG 561

  Fly   891 ACCMDMNVSITLSALYTLATQLFGG---YLSSRIPEGLSWIRYTSMIHYAYQNMQILEFREGAAI 952
            |....:.|......:|.:....|.|   |..|.:|: ||||:|.::.||.::.:...||     :
  Rat   562 AGENAVAVPTLFVTIYFVFMLFFSGLSLYSGSLLPQ-LSWIQYFNIPHYGFKALLHNEF-----L 620

  Fly   953 G---CGSPSSYEICKQQSTEFIPYEEILKAQN---STSPLWLNTLILMMFFLVFRCLGYAVL 1008
            |   |...:..|:.:..:......||.|..|.   |:...|.|.|.|....::...:.|..|
  Rat   621 GQNFCSEHNIEEVSRCHNYVICTGEEFLTIQGIDLSSWGFWENHLALACIMIILLTITYVQL 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	73/235 (31%)
		3a01204	363..1009	CDD:273361	167/675 (25%)
		ABC2_membrane	744..943	CDD:279410	57/207 (28%)
Abcg3	XP_038948191.1	3a01204	109..683	CDD:273361	167/667 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010