DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and st

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster

Alignment Length:	754	Identity:	187/754 - (24%)
Similarity:	314/754 - (41%)	Gaps:	162/754 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 IGKSILVDAKSNSPASLSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNV 360
            :|.:|.|.:..::|        |.:..|..::...:...:...|       .:....|.:::|.|
  Fly    27 VGSTIEVPSLDSTP--------KLSKRNSSERSLPLRSYSKWSP-------TEQGATLVWRDLCV 76

  Fly   361 LHN-------ERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQR---HIDSGSVFLNREP 415
            ..|       .::|:::.:|.:.|..::|:||.||||||||:..|:.::   .:..|.:.:|...
  Fly    77 YTNVGGSGQRMKRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRR 141

  Fly   416 LTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTK 480
            :.....|..|||.|:::|...||:.|.:.:.|.|||...:.:.|:...:..:||...|....||:
  Fly   142 IGPFMHRISGYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTR 206

  Fly   481 FGDYLNRG-LSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVI 544
            .|...::. |||||:||...|.|||.||:::..||||:||||:||..|:..|...|| :..||:.
  Fly   207 IGSGDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQ-KGTTILC 270

  Fly   545 SVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLKSHPDIR 609
            ::||||||:|..|:.::||..||.|:.|..|:....|.:.|......||||||::..|.:.|.
  Fly   271 TIHQPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVLATDPG-- 333

  Fly   610 EKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQRSNRHHHQYEN 674
                                                               |.|.|.|
  Fly   334 ---------------------------------------------------YEQASQR------- 340

  Fly   675 LHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASS-------DCHSYSAGSGPGHSADDDW-- 730
                           :||||  |   .|...||.|..       :.|...:|:.|..:..:.:
  Fly   341 ---------------SAQHL--C---DQFAVSSAAKQRDMLVNLEIHMAQSGNFPFDTEVESFRG 385

  Fly   731 LSYPTSFHTQFCVLSSRNFREAKPRMLSKLNWFQTIGLALMAGAIWFQLPRTEEF-LHDLQGWMF 794
            :::...||..:...|....|:.   .:..|.:.|.|.:|.:.||.:.......:. :..:||.:|
  Fly   386 VAWYKRFHVVWLRASLTLLRDP---TIQWLRFIQKIAMAFIIGACFAGTTEPSQLGVQAVQGALF 447

  Fly   795 F---SQTYWMLFALFGALNSFPSEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMIS 856
            .   ..||   ..::..||.||....:..:|.|||.|....||.|.:.|.||.:|..|.::::|.
  Fly   448 IMISENTY---HPMYSVLNLFPQGFPLFMRETRSGLYSTGQYYAANILALLPGMIIEPLIFVIIC 509

  Fly   857 YPMLGCTSLKLFF---LMLIFLLINTIVAQSVGFFIGACC----MDMNVSITLSALYTLATQLFG 914
            |.:.|..|....|   .|.:.|::|  ||.:.|.|.....    :.|...:.|..::.:.:.:|
  Fly   510 YWLTGLRSTFYAFGVTAMCVVLVMN--VATACGCFFSTAFNSVPLAMAYLVPLDYIFMITSGIF- 571

  Fly   915 GYLSSRIPEGLSWIRYTSMIHYAYQNM---------QILEFREGAAIGCGSPSSYEICKQQSTEF 970
             ...:.:|....|.::.|.:.||.:.|         .|..|:|.|.:.|               |
  Fly   572 -IQVNSLPVAFWWTQFLSWMLYANEAMTAAQWSGVQNITCFQESADLPC---------------F 620

  Fly   971 IPYEEIL-KAQNSTSPLWLNTLILMMFFLVFRCLGYAVL 1008
            ...:::| |...:.|.::.|.|.::..:..|..|||..|
  Fly   621 HTGQDVLDKYSFNESNVYRNLLAMVGLYFGFHLLGYYCL 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	83/232 (36%)
		3a01204	363..1009	CDD:273361	177/687 (26%)
		ABC2_membrane	744..943	CDD:279410	51/218 (23%)
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	83/232 (36%)
		3a01204	67..665	CDD:273361	180/699 (26%)
		ABC2_membrane	395..600	CDD:279410	51/214 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm2959
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	7	6.920