DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and CG5853

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster

Alignment Length:	788	Identity:	194/788 - (24%)
Similarity:	322/788 - (40%)	Gaps:	184/788 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 SSNGLANIGKSILVDAKSNS--------PASLS---YHFEKSAAANQQKQHHNINICNSHHPHHH 342
            |.||:|.:|..|.:...::|        |...|   .:.:.|...........:|..|.:.|...
  Fly    12 SDNGVAGLGLGIEIGEVTSSRVYNSTTVPVGNSGGWRNAQSSVTPPPIPTPPQVNYTNGNEPSKQ 76

  Fly   343 SQNQP------------------QHSLQLTFQNLNVL------HNERQILSDVSGFVSPCEVLAI 383
            ...:|                  :..:.:.|:.|::.      ...::||.:|.|.....:::||
  Fly    77 PPLEPVVEEEVHFDTDALNNLPAREPVDMEFKELSLTVKLGFNRGSKEILHNVCGKFPGSQLIAI 141

  Fly   384 MGPSGSGKTTLLDCLSGQR--HIDSGSVFLN-REPLTKKWRRRIGYVLQEEIFFPQLTLRETVVY 445
            |||||:||:||||.|||.:  .:| ||:.|| |......:||...|:.|::...|.||:.|.:..
  Fly   142 MGPSGAGKSTLLDALSGFKTTGVD-GSILLNGRRRDLPSFRRMSCYITQDDRLQPLLTVNENMHI 205

  Fly   446 TALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLM 510
            .|.|:|.:::...||..:::.||..|.|....||     |...||||:|||.:||.||:.||.:|
  Fly   206 AADLKLGQTVSYEEKESRIEDILLLLGLYNHDQT-----LTMRLSGGQKKRLSIAMELINNPTVM 265

  Fly   511 LLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQ 575
            .|||||:||||.|...::::||:... :.:||:.::|||::::|.:||::.:|..|...|.|..|
  Fly   266 FLDEPTTGLDSSSCTKVLELLKKLTS-QGRTIICTIHQPTAKLFQIFDQVYVLSAGNCVYQGSTQ 329

  Fly   576 NIYRHFEDIGVTIKPHYNPADFVLEQL--KSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVS 638
            .:....:.:.:....::||||:::|..  :...|..:.|.:|.:       |.:|:|..|:
  Fly   330 KLVPFLQSVDLPCPMYHNPADYIIELACGEYGYDKVDTLKLATE-------NGSCLTWFHN---- 383

  Fly   639 VSGAKGKKQADSILIDDIINNYY---NQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAAD 700
                     ..::|..:::...|   .:..:|
  Fly   384 ---------PSAVLRAEVLMRKYPIPKKTKSR--------------------------------- 406

  Fly   701 SQSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSSRNFREAK-PRMLSKLNWFQ 764
                                    |.:|      ||:..|..||..|.|.:|| ...::.|....
  Fly   407 ------------------------SLED------TSYSNQCSVLLRRGFIKAKRDTTMTHLRIGV 441

  Fly   765 TIGLALMAGAIWFQLPRTEEFLHDLQGWMF-----FSQTYWMLFALFGALNSFPSEREVVSKERR 824
            .|.:|.:.||::....|....:.|....:|     .|.|..||..|     :||.:..::.||..
  Fly   442 NIAVAALFGAMYDHTGREGSRVLDNYNLLFAILMHHSMTTMMLTVL-----TFPMDISILIKEHF 501

  Fly   825 SGAYRLSAYYLAKMCAELPLVIT-----LPTVYLMISYPMLGCTSLKLFFLMLIFLLINTIVAQS 884
            :..|.|.|||.|....:||:.|.     ...|||....||    ....||:.....|:...|..|
  Fly   502 NRWYSLKAYYTAMTLVDLPISIISCFFFTVIVYLWSYQPM----EWIRFFMFFSISLLTVFVGHS 562

  Fly   885 VGFFIGACCMDMNVSITLSALYTLATQLFGGY-LSSR-IPEGLSWIRYTSMIHYAYQN-MQILEF 946
            .|..||| ..|:.....|:.:.|:...:|.|: ::.| :|..|.|..:.|.:.|..:. :..:..
  Fly   563 FGLMIGA-WFDVVNGTFLAPVLTIPMMMFAGFGVTLRDLPSYLRWGSHISYLRYGLEGFISAIYG 626

  Fly   947 REGAAIGCGSPSSYEICKQQSTEFIPY----------EEILKAQNSTSPLWLNTLILMMFFLVFR 1001
            .:...:.|              |..||          |||....:.   .|.:.:.|.:..||||
  Fly   627 LDRGTLAC--------------EEAPYCHYRYPKKFLEEITMRGDQ---FWNDVIALGVMILVFR 674

  Fly  1002 CLGYAVLR 1009
            .:.|.||:
  Fly   675 FVSYVVLK 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	85/230 (37%)
		3a01204	363..1009	CDD:273361	177/677 (26%)
		ABC2_membrane	744..943	CDD:279410	56/212 (26%)
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	180/703 (26%)
		ABCG_EPDR	102..326	CDD:213180	85/230 (37%)
		ABC2_membrane	420..623	CDD:279410	56/212 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I2350
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	8	7.820