DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and CG3164

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster

Alignment Length:	711	Identity:	196/711 - (27%)
Similarity:	315/711 - (44%)	Gaps:	97/711 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 HSQNQPQHSLQLTFQNLNV------LHNERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSG 400
            |...:|  ::.|.|.||..      ..|.:.||..|||.:...|:.|||||||:||:|||:.|||
  Fly    38 HLPKRP--AVDLAFHNLTYRVKEGNRSNAKTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILSG 100

  Fly   401 QRHID-SGSVFLN-REPLTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQ 463
            .:... .|||.:| .|.....:|:...|::|:......||::|.:.....|:|.:...:.||...
  Fly   101 YKTSSIEGSVTMNGAERNLSAFRKLSAYIMQDNQLHGNLTVQEAMTVATNLKLSKKFSKPEKHSM 165

  Fly   464 VDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLM 528
            :|.||..|.|...:.|     :.|.||||:|||.:||.||::||.:|..|||||||||.:....:
  Fly   166 IDDILLTLSLSEHRYT-----MTRNLSGGQKKRLSIALELVSNPPIMFFDEPTSGLDSSTCFQCI 225

  Fly   529 KVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYN 593
            .:||..| ...:|::.::||||:::|.|||:|..|..|:..|.|..:.:......:.:....::|
  Fly   226 HLLKMLA-AGGRTVICTIHQPSARLFEMFDQLYTLADGQCVYQGSTKQLVPFLSTLNLECPSYHN 289

  Fly   594 PADFVLE-QLKSHPDIREKLFIAAK------ESHGNYLN---RNCITSSHH-----NQVSVSGAK 643
            ||.:|:| ....|.|...||..|..      .|..:|..   ||.:....:     ::...|...
  Fly   290 PASYVIEVSCGEHGDHTRKLVDAIDNGKRDVRSSADYAGLKARNDLVKVQNLKAILDKNDASSVS 354

  Fly   644 GKKQADSILIDD-IINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSS 707
            |:|..|::.::: ::|...|.                    :.::...:..||.......:....
  Fly   355 GRKYEDNLTLNNGLLNGMVND--------------------IVKEGNVSSALVTTNERGDAMIDV 399

  Fly   708 CASSDCHS---YSAGSGPGHSADDDWLSYPTSFHTQFCVLSSRNFREAKPRMLSKLNW------- 762
            ..|.:|.:   ....:.|..        ||||...||.|:..|..      :.|..:|
  Fly   400 EKSVNCTTALLTEEITSPER--------YPTSQFHQFWVVLKRTL------LFSYRDWTLMYLRL 450

  Fly   763 FQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSFPSEREVVSKERRSGA 827
            |..:.:..:.||:::.:......:....|::||:..:.|..::...:.|||.|..|:.||..:..
  Fly   451 FAHLLVGFLIGALYYDIGNDGAKVLSNLGFLFFNMLFLMYTSMTITILSFPLEMPVLLKENFNRW 515

  Fly   828 YRLSAYYLAKMCAELPL-----VITLPTVYLMISYPMLGCTSLKLFFLMLIFLLINTIVAQSVGF 887
            |.|.:||||...|:||.     ||.:..||...|.|.    .|..|.:.|...|:.:.||||||.
  Fly   516 YSLKSYYLAISVADLPFQAIFCVIYVSIVYYFTSQPW----ELFRFSMFLSACLLISFVAQSVGL 576

  Fly   888 FIGACCMDMNVSITLSALYTLATQLFGGYLSS--RIPEGLSWIRYTSMIHYAYQNMQILEFREGA 950
            .:|| .|::...:.|:.:.::...||.|:..|  .||..|.||.|.|.|.|.::...:      |
  Fly   577 VVGA-AMNVQNGVFLAPVMSVPFLLFSGFFVSFDAIPVYLRWITYLSYIRYGFEGTAL------A 634

  Fly   951 AIGCGSPSSYEICKQQSTEF-IPYEEILKAQNSTSPLWLNTLILMMFFLVFRCLGYAVLRF 1010
            ..|.|.....  |.|....| .|...:.:.....:...|:.:.|::.|:|.|...|..||:
  Fly   635 TYGYGREKLR--CFQTYCHFKSPITTLEELDMVNANFTLDIVALIVIFVVLRISAYLFLRW 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	87/229 (38%)
		3a01204	363..1009	CDD:273361	188/681 (28%)
		ABC2_membrane	744..943	CDD:279410	59/212 (28%)
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	87/229 (38%)
		3a01204	60..699	CDD:273361	190/687 (28%)
		ABC2_membrane	431..630	CDD:279410	59/209 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I2350
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	8	7.820