DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and w

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster

Alignment Length:	796	Identity:	227/796 - (28%)
Similarity:	364/796 - (45%)	Gaps:	163/796 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 SSASSSASSTSSSSSSSTSSEFTHTSQTTIPSTDNLTSSNGLANIGKSILVDAKSNSPASLSYHF 316
            ::..|.|:|.|..:.....::...|.:...|..|:.:.|..||.               :|:|.:
  Fly    23 NNGDSGAASQSCINQGFGQAKNYGTLRPPSPPEDSGSGSGQLAE---------------NLTYAW 72

  Fly   317 EKSAAANQQKQHHNINICNSHHPHHHSQNQPQHS-LQLTFQNLNVLHNERQI-------LSDVSG 373
                        ||::|..       :.|||... .||..:...:..|||.|       |.:|.|
  Fly    73 ------------HNMDIFG-------AVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCG 118

  Fly   374 FVSPCEVLAIMGPSGSGKTTLLDCLS-----GQRHIDSGSVFLNREPL-TKKWRRRIGYVLQEEI 432
            ...|.|:||:||.||:||||||:.|:     |.:...||...||.:|: .|:.:.|..||.|:::
  Fly   119 VAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDDL 183

  Fly   433 FFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFG-DYLNRGLSGGEKKR 496
            |...||.||.:::.|::|:|..:...:::.:||.:::.|.|..||.|..| ....:||||||:||
  Fly   184 FIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKR 248

  Fly   497 ANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLL 561
            ...|.|.||:|.|::.|||||||||.:|.|:::|||:.:| :.||:::::|||||::|.:|||:|
  Fly   249 LAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQ-KGKTVILTIHQPSSELFELFDKIL 312

  Fly   562 LLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLKSHP--DIREKLFIAAKESHGNYL 624
            |:.:||.|:.|........|..:|.....:||||||.::.|...|  :|..:..||
  Fly   313 LMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGREIESRDRIA--------- 368

  Fly   625 NRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEE 689
                                 |..|:..|..:..:            .|.|..|.|   :|:..|
  Fly   369 ---------------------KICDNFAISKVARD------------MEQLLATKN---LEKPLE 397

  Fly   690 AAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSSRNFREA-K 753
            ..::                             |:       :|..::..||..:..|::... |
  Fly   398 QPEN-----------------------------GY-------TYKATWFMQFRAVLWRSWLSVLK 426

  Fly   754 PRMLSKLNWFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSFPSEREV 818
            ..:|.|:...||..:|::.|.|:.....|:..:.::.|.:|...|......:|..:|.|.||..|
  Fly   427 EPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSELPV 491

  Fly   819 VSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCTSLKLFF---LMLIFLLINTI 880
            ..:|.||..||...|:|.|..|||||.:|:|.|:..|:|||:|..:..|.|   |.|:.|:.|
  Fly   492 FMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVLHFFNCLALVTLVAN-- 554

  Fly   881 VAQSVGFFIGACCMDMNVSITLSALYTLATQLFGGYL--SSRIPEGLSWIRYTSMIHYAYQNMQI 943
            |:.|.|:.|.......::::::.....:...||||:.  |..:|..|.|:.|.|...||.:.:.|
  Fly   555 VSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLI 619

  Fly   944 LEFR--EGAAIGCGS-----PSSYEICKQQSTEFIPYEEILKAQN-STSPLWLNTLILMMFFLVF 1000
            .::.  |...|.|.|     |||.::             ||:..| |.:.|.|:.:.|.:..:.|
  Fly   620 NQWADVEPGEISCTSSNTTCPSSGKV-------------ILETLNFSAADLPLDYVGLAILIVSF 671

  Fly  1001 RCLGYAVLRFLRCPKK 1016
            |.|.|..|| ||..:|
  Fly   672 RVLAYLALR-LRARRK 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	96/236 (41%)
		3a01204	363..1009	CDD:273361	202/675 (30%)
		ABC2_membrane	744..943	CDD:279410	62/204 (30%)
w	NP_476787.1	3a01204	68..687	CDD:273361	217/736 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I2350
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm2959
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	9	8.820