Protein Alignment E23 and Abcg2

DIOPT Version :9

• Sequence 1: NP_524648.3
• Gene: E23 / 43895
• FlyBaseID: FBgn0020445
• Length: 1017
• Species: Drosophila melanogaster
• Sequence 2: NP_852046.1
• Gene: Abcg2 / 312382
• RGDID: 631345
• Length: 657
• Species: Rattus norvegicus
• Alignment Length: 672
• Identity: 199/672 - (29%)
• Similarity: 321/672 - (47%)
• Gaps: 99/672 - (14%)

  Fly   364 ERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHID----SGSVFLNREPLTKKWRRRI 424
            |::||||::|.:.| .:.||:||:|.||::|||.|:.::  |    ||.|.:|..|....::...
  Rat    59 EKEILSDINGIMKP-GLNAILGPTGGGKSSLLDVLAARK--DPRGLSGDVLINGAPQPANFKCSS 120

  Fly   425 GYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGL 489
            |||:|:::....||:||.:.::|.||||::|...||..:::.|::.|.|.....:|.|....||:
  Rat   121 GYVVQDDVVMGTLTVRENLQFSAALRLPKAMKTHEKNERINTIIKELGLDKVADSKVGTQFTRGI 185

  Fly   490 SGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMF 554
            ||||:||.:|..||:|:|.::.|||||:||||.:|.:::.:|||.:: :.:||:.|:|||...:|
  Rat   186 SGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK-QGRTIIFSIHQPRYSIF 249

  Fly   555 HMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKES 619
            .:||.|.||..|:..:.|..|....:|...|...:|:.|||||.|:.:..             :|
  Rat   250 KLFDSLTLLASGKLMFHGPAQKALEYFASAGYHCEPYNNPADFFLDVING-------------DS 301

  Fly   620 HGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCRV 684
            ....|||.  ...|....:...:|.:|.    :|:::...|.|.              |..|
  Rat   302 SAVMLNRG--EQDHEANKTEEPSKREKP----IIENLAEFYINS--------------TIYG--- 343

  Fly   685 EEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSSRNF 749
            |...|..|..|                      |....|.||..:.: |.|||..|...::.|:|
  Rat   344 ETKAELDQLPV----------------------AQKKKGSSAFREPV-YVTSFCHQLRWIARRSF 385

  Fly   750 RE--AKPRMLSKLNWFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSF 812
            :.  ..|: .|......|:.|.|:.||::|.|......:.:..|..||..|. ..|....|:..|
  Rat   386 KNLLGNPQ-ASVAQLIVTVILGLIIGALYFGLKNDPTGMQNRAGVFFFLTTN-QCFTSVSAVELF 448

  Fly   813 PSEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTV-YLMISYPMLGC-TSLKLFFLMLIFL 875
            ..|:::...|..||.||:|:|:..|:.::|..:..||:| |..:.|.|||. .:::.||:|:..|
  Rat   449 VVEKKLFIHEYISGYYRVSSYFFGKLVSDLLPMRFLPSVIYTCLLYFMLGLKRTVEAFFIMMFTL 513

  Fly   876 LINTIVAQSVGFFIGACCMDMNVSITLSALYTLATQLFGGYLSS--RIPEGLSWIRYTSMIHY-- 936
            ::....|.|:...|.|....::|:..|..:..:...||.|.|.:  .|...|||::|.|:..|
  Rat   514 IMVAYTASSMALAIAAGQSVVSVATLLMTISFVFMMLFSGLLVNLRTIGPWLSWLQYFSIPRYGF 578

  Fly   937 -AYQNMQIL--EFREGAAIGCGSP--SSYEICK------QQSTEFIPYEEILKAQNSTSPLWLNT 990
             |.|:.:.|  ||..|..:...|.  :||.||.      .|..:..|:           .||.|.
  Rat   579 TALQHNEFLGQEFCPGLNVTMNSTCVNSYTICTGNDYLINQGIDLSPW-----------GLWRNH 632

  Fly   991 LILMMFFLVFRCLGYAVLRFLR 1012
            :.|....::|..:.|..|.||:
  Rat   633 VALACMIIIFLTIAYLKLLFLK 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	84/211 (40%)
		3a01204	363..1009	CDD:273361	196/667 (29%)
		ABC2_membrane	744..943	CDD:279410	59/207 (29%)
Abcg2	NP_852046.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		3a01204	46..651	CDD:273361	196/667 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51839
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730