DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E23 and Abca12

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	XP_237242.6	Gene:	Abca12 / 301482	RGDID:	1304586	Length:	2595	Species:	Rattus norvegicus

Alignment Length:	364	Identity:	80/364 - (21%)
Similarity:	153/364 - (42%)	Gaps:	48/364 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 HSLQLTFQNLNVLHNERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHIDSGSVFLNR 413
            |.|..|:|   ::|.:...::::|..:...|...::|.:|:||||:...|:|.....||::.:..
  Rat  2257 HRLTKTYQ---LIHKKIIAVNNISLGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRN 2318

  Fly   414 EP----LTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELG 474
            :.    ........:||..||:.....:|:.|.:.:.|.:   ..:|..:....|..:|..|.|
  Rat  2319 KSGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARV---HGIPEKDIKETVHKLLRRLHL- 2379

  Fly   475 CCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQ 539
                ..:.|......|.|.|::.:.|..|:..|.::|||||:||:|..|...|.:::..  :::.
  Rat  2380 ----MAYKDRSTSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWRIISE--EVQN 2438

  Fly   540 KTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLKS 604
            |..||.......:...:..:|.::..||....|.:|:|...| ..|.|:|.|.......:|.|..
  Rat  2439 KCSVILTSHSMEECEALCTRLAIMVNGRFQCIGSLQHIKSRF-GRGFTVKVHLKNNKVSMENLTK 2502

  Fly   605 HPDIR-EKLFIAAKESHGNYLNRNCITSSHHNQVSVSGA-------KGKKQADSI--------LI 653
            ...:. .|.::  |:.|.:.|       .:|..|:..|.       :..|.|.:|        .:
  Rat  2503 FMQLHFPKTYL--KDQHLSML-------EYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTL 2558

  Fly   654 DDIINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQ 692
            :::..|:...:.:     |||:..:|.|..:..|.:..|
  Rat  2559 EEVFINFAKDQKS-----YENVDTSSQGSTISVDSQEDQ 2592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	51/225 (23%)
		3a01204	363..1009	CDD:273361	75/350 (21%)
		ABC2_membrane	744..943	CDD:279410
Abca12	XP_237242.6	ABC2_membrane_3	<1006..1267	CDD:289468
		NosY	<1108..1269	CDD:224196
		ZnuC	1346..1570	CDD:224046
		ABC_subfamily_A	1350..1565	CDD:213230
		ABC2_membrane_3	<1913..2174	CDD:289468
		CcmA	2253..2567	CDD:224054	73/332 (22%)
		ABC_subfamily_A	2254..2477	CDD:213230	54/232 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000