DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E23 and Abcg3l1

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_001004076.2	Gene:	Abcg3l1 / 289453	RGDID:	1303294	Length:	646	Species:	Rattus norvegicus

Alignment Length:	698	Identity:	176/698 - (25%)
Similarity:	301/698 - (43%)	Gaps:	131/698 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 LTFQNLNV---------LHNERQI---LSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHID 405
            |:|.|::.         |..:.::   ||.:||.:.| .:.|||||....::.|||.|:.:|  |
  Rat    37 LSFHNISYRETVQSGFPLRQQTRVMERLSSISGIMGP-GLNAIMGPQDGSRSLLLDVLAARR--D 98

  Fly   406 ----SGSVFLNREPLTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDH 466
                ||.:.:|.:|....::...||:.|.::....:|:|:.:.::|.||||.::.|.||.|:::.
  Rat    99 PCGLSGDILINGKPRPANFKCTSGYIPQNDVVLGTVTVRDNLEFSAALRLPMTVTRDEKRRRINE 163

  Fly   467 ILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVL 531
            :||.|.|...|..|       ..|.|.:||.:||.||:|...::.||:||:|||..:...::.:|
  Rat   164 VLELLHLEKEQNVK-------PRSKGLRKRTSIAMELVTEHPILFLDDPTTGLDLRTTTDVISIL 221

  Fly   532 KRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPAD 596
            :|.: ::.|||:.|::||...:|..||.|.|:..|:..:.|..::...:|...|...:.|.||||
  Rat   222 RRMS-MKGKTIIFSINQPQYSIFRFFDSLTLVASGKLMFHGPARDALEYFTSAGYQYESHNNPAD 285

  Fly   597 FVLEQLK-SHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNY 660
            |.|:.:. ..||..|       :.|....|...:...|    .|:|......|.|.|
  Rat   286 FFLDVINGGFPDTEE-------DGHEADENEEFVERQH----QVTGKLANMYAQSPL-------- 331

  Fly   661 YNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHS 725
                            |::...|:::          ...:.:.:.||...:.|
  Rat   332 ----------------HSATRARLDQ----------LLGEQKLDRSSAVETTC------------ 358

  Fly   726 ADDDWLSYPTSFHTQFCVLSSRNFREAKPRMLSKLNWFQTIG------LALMAGAIWFQLPRTEE 784
                    .|.|..|...::.|:|:.     .....|..||.      ||::.|.. |:|  .:.
  Rat   359 --------VTPFWHQLGWITRRSFKN-----FLGFPWVTTIQVIIIVILAVVVGTA-FRL--LQN 407

  Fly   785 FLHDLQGWMFFSQTYWMLFALFGALNS------FPSEREVVSKERRSGAYRLSAYYLAKMCAEL- 842
            ...:||    ......:|...|..:.|      |..:::....|..||.||:|:|:..|:.|||
  Rat   408 VCTELQ----MRAILILLLTGFQCITSVTAGELFVIDQDRFLHEHTSGYYRVSSYFFGKLLAELI 468

  Fly   843 PLVITLPTVYLMISYPMLGC-TSLKLFFLMLIFLLINTIVAQSVGFFIGACCMDMNVSITLSALY 906
            |..:...|::.:|:|.:.|. ||::.||.|...:::....|.|:...:||......::..|..:|
  Rat   469 PRRLLPSTIFTLITYFIAGLRTSVRGFFTMTFTIMMLAYSASSLSLSLGAGENVAAITTLLVTIY 533

  Fly   907 TLATQLFGGY-LSSRIPEGLSWIRYTSMIHYAYQNMQILEFREGAAIG---CGSPSSYEICKQQS 967
            .:....|.|. |.:.....||||||.|:.||.::.:...||     :|   |...::.|:.:.|:
  Rat   534 FVFMLFFSGLSLDTGFLPVLSWIRYFSIPHYGFRALLHNEF-----LGQNFCPEYNTEEVSRCQN 593

  Fly   968 TEFIPYEEILKAQN---STSPLWLNTLILMMFFLVFRCLGYAVLRFLR 1012
            ......||.|:.|.   |:...|.|.|.|....::...:.|..|..|:
  Rat   594 YVICTGEEFLEIQGFHLSSWGFWENHLALACTMIILLTITYVQLLLLK 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	74/234 (32%)
		3a01204	363..1009	CDD:273361	170/674 (25%)
		ABC2_membrane	744..943	CDD:279410	55/213 (26%)
Abcg3l1	NP_001004076.2	P-loop_NTPase	35..261	CDD:304359	74/234 (32%)
		3a01204	64..644	CDD:273361	172/671 (26%)
		ABC2_membrane	369..572	CDD:279410	55/214 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51839
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730