DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E23 and Abca17

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_001026807.1	Gene:	Abca17 / 287112	RGDID:	1560494	Length:	1773	Species:	Rattus norvegicus

Alignment Length:	266	Identity:	73/266 - (27%)
Similarity:	125/266 - (46%)	Gaps:	23/266 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 LTFQNLNVLHNERQIL---SDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHIDSGSVFLN-- 412
            |..:.|:.::.|:..|   :.||..|...|...::|.:|:|||::.:.|:.::.|.||..|:.
  Rat  1369 LVVKELSKVYKEKVPLLAVNKVSFVVKEKECFGLLGLNGAGKTSIFNMLTREQPITSGDAFVKGF 1433

  Fly   413 --REPLTK--KWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALEL 473
              |..:.|  :|   |||..:.:.....:|.||.:|..|.:|   .:|.......||.|||.| |
  Rat  1434 NIRTDMAKVQQW---IGYCPEFDALLNFMTGREMLVMHARIR---GIPECHIKTCVDMILENL-L 1491

  Fly   474 GCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLE 538
            .|.    :.|.|.:..|.|.|:..:.|..||..|.::|||||::|:|..:...:...:.|..: .
  Rat  1492 MCV----YADKLVKTYSDGNKRVLSTAIALLGEPTVILLDEPSTGMDPVARRLVWDAVGRVRE-S 1551

  Fly   539 QKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHF-EDIGVTIKPHYNPADFVLEQL 602
            .|||||:.|. ..:...:..:|.::.||:....|..|::...| ....:..|........:||:.
  Rat  1552 GKTIVITSHS-MEECEALCTRLAIMVQGQFKCLGSPQHLKSRFGSGYSLQAKVRRKWQQQMLEEF 1615

  Fly   603 KSHPDI 608
            |:..|:
  Rat  1616 KAFVDL 1621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	65/227 (29%)
		3a01204	363..1009	CDD:273361	71/256 (28%)
		ABC2_membrane	744..943	CDD:279410
Abca17	NP_001026807.1	ABC2_membrane_3	<262..464	CDD:289468
		ABC_subfamily_A	525..746	CDD:213230
		drrA	543..834	CDD:130256
		ABC2_membrane_3	913..1255	CDD:289468
		CcmA	1369..1682	CDD:224054	73/266 (27%)
		ABC_subfamily_A	1369..1590	CDD:213230	67/233 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1690..1773
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000