DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and Abca5

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_775429.1	Gene:	Abca5 / 286970	RGDID:	628661	Length:	1642	Species:	Rattus norvegicus

Alignment Length:	813	Identity:	156/813 - (19%)
Similarity:	301/813 - (37%)	Gaps:	254/813 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 QILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHIDSG--SVFLNREPLTKKW---RRRIG 425
            :.|.::|..:...::.|::|.||:||:||::.|.|......|  |::.:|.....:.   |:.||
  Rat   495 EALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIG 559

  Fly   426 YVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLS 490
            ...|.::.|..||:.|.:   ::|...:.:|....:::|..:|..|::   |..|  |...:.||
  Rat   560 ICPQSDMNFDVLTVEENL---SILASVKGIPANNIIQEVQKVLLDLDM---QAIK--DNQAKKLS 616

  Fly   491 GGEKKRANIACELLTNPLLMLLDEPTSGLD---SHSAISLMKVLK-------------------- 532
            ||:|::.::...:|.||.::||||||:|:|   .|...:|:|..|
  Rat   617 GGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILAD 681

  Fly   533 ----------------------------------RYAQLEQKTIVISVHQPSSQMFHMFDKLLL- 562
                                              ||...|..:.::..|.|::.:....|:.::
  Rat   682 RKAVISQGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCATESLSSLVRQHIPAAALLQQNDQQIVY 746

  Fly   563 ------------------LHQ--GRTAYFGDVQNIYRHFEDI--GVTIKPHYNPADF-VLEQ--- 601
                              :|.  |..:|...:..:    ||:  .:.::...:.||: |..|
  Rat   747 SLPFKDMDKFSGLFSALDIHSNLGVISYGVSMTTL----EDVFLKLEVEAEIDQADYSVFTQQPR 807

  Fly   602 -----LKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVS-------VSGAKGKKQADSILID 654
                 .||..::.:.|.|.: |:..:.::   ..|....|||       :|..:..|...|:|:.
  Rat   808 EEETDSKSFDEMEQSLLILS-ETKASLVS---TMSLWKQQVSTIAKFHFLSLKRESKSVRSVLLL 868

  Fly   655 DIINNYYNQRSNRHHHQYEN----------LHHTSNGCRVEEDEEAAQHLVWCAADS-------- 701
            .:|...........||.::|          |:....|.:..:.:.:.  |:..:.||
  Rat   869 LLIFFAVQIFMFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSL--LLQNSTDSDINDLIDF 931

  Fly   702 --QSNFSSCASSDCHSYSAGSGPGHSA-------DDDWLSYPTSFHTQFCVLSSRNFREAKPRML 757
              |.|......:|....||..   |||       :.|::         |..:.:.....:.|.|:
  Rat   932 FTQQNIIVAMFNDSDYVSAAP---HSAALNVVQSEKDYV---------FTAVFNSTMVYSLPVMM 984

  Fly   758 S--------KLNWFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGAL-NSFP 813
            :        .||...||       .||     :..|:.::...:|..:.|:.. ||.|.: .:.|
  Rat   985 NIISNYYLYHLNVTDTI-------QIW-----STPFIQEITDIVFKVELYFQA-ALLGIIVTAMP 1036

  Fly   814 SEREVVSKERRSGAYRLSAYYLAKMCAELP-------LVITLPTVYLMISYPMLGCTSLKLF--- 868
            ....:.:.|.    :::.||...|:...||       .|:.:|..:::::. |||  ||..|
  Rat  1037 PYFAMENAEN----HKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFVVLTL-MLG--SLFAFHHG 1094

  Fly   869 -------FLMLIFLLINTIVAQSVGFFIGACCMDMNVSITLSALYTLATQLFGGYLSS------- 919
                   ||.::|.||..:.:..:..:|        .|.|...:  |.|:.|..::.|
  Rat  1095 LYFYPVKFLAVVFCLIAYVPSVILFTYI--------ASFTFKKI--LNTKEFWSFIYSVTALACV 1149

  Fly   920 RIPEGLSWIRY--TSMIHYAYQNMQILEFREGAAIGCGSPSSYEICKQQSTEFI--PYEEILKAQ 980
            .:.|...::.|  |::.||.:    .:.......:||            ...||  .::.|.|.:
  Rat  1150 AVTEITFFLGYGVTAVFHYTF----CIAIPIYPLLGC------------LISFIKGSWKNIPKTE 1198

  Fly   981 NSTSPLWLNTLILMMFFLVFRCLGYAVLRFLRC 1013
            |:.:| |...|:.:            ::.:|:|
  Rat  1199 NAYNP-WDRLLVAV------------IMPYLQC 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	60/288 (21%)
		3a01204	363..1009	CDD:273361	154/807 (19%)
		ABC2_membrane	744..943	CDD:279410	46/233 (20%)
Abca5	NP_775429.1	ABC2_membrane_3	<214..416	CDD:289468
		CcmA	476..788	CDD:224054	62/304 (20%)
		ABC_subfamily_A	478..701	CDD:213230	51/213 (24%)
		ABC2_membrane_3	<957..1224	CDD:289468	60/330 (18%)
		CcmA	1288..1615	CDD:224054
		ABC_subfamily_A	1290..1521	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000