Protein Alignment E23 and Abcg5

DIOPT Version :10

• Sequence 1: NP_524648.3
• Gene: E23 / 43895
• FlyBaseID: FBgn0020445
• Length: 1017
• Species: Drosophila melanogaster
• Sequence 2: NP_114090.1
• Gene: Abcg5 / 27409
• MGIID: 1351659
• Length: 652
• Species: Mus musculus
• Alignment Length: 713
• Identity: 175/713 - (24%)
• Similarity: 294/713 - (41%)
• Gaps: 151/713 - (21%)

  Fly   346 QPQHSLQLTFQNLNVLHN--------------ERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLD 396
            :.:|||.:...:.:|.:.              :||||.|||.::...:::.|:|.||||||||||
Mouse    34 EARHSLGVLHVSYSVSNRVGPWWNIKSCQQKWDRQILKDVSLYIESGQIMCILGSSGSGKTTLLD 98

  Fly   397 CLSGQ-RHIDS--GSVFLNREPLTK-KWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPR 457
            .:||: |...:  |.||:|...|.: :::....||||.::|...||:|||:.|||:|.|..|...
Mouse    99 AISGRLRRTGTLEGEVFVNGCELRRDQFQDCFSYVLQSDVFLSSLTVRETLRYTAMLALCRSSAD 163

  Fly   458 AEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSH 522
            ... ::|:.::..|.|........|.|...|:|.||::|.:||.:||.:|.:|:|||||:|||..
Mouse   164 FYN-KKVEAVMTELSLSHVADQMIGSYNFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCM 227

  Fly   523 SAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVT 587
            :|..::.:|...|: ..:.:::::|||.|::|..|||:.:|..|...:.|..:.:...|.:.|..
Mouse   228 TANQIVLLLAELAR-RDRIVIVTIHQPRSELFQHFDKIAILTYGELVFCGTPEEMLGFFNNCGYP 291

  Fly   588 IKPHYNPADFVLEQLKSHPDIREK----------LFIAAKESHGNYLNRNCITSSHHNQVSVSGA 642
            ...|.||.||.::........||:          |..|.|||
Mouse   292 CPEHSNPFDFYMDLTSVDTQSREREIETYKRVQMLECAFKES----------------------- 333

  Fly   643 KGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSS 707
                        ||           :|...||:             |.|::|
Mouse   334 ------------DI-----------YHKILENI-------------ERARYL------------- 349

  Fly   708 CASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVL---SSRNFREAKPRMLSKLNWFQTIGLA 769
                    .:..:.|..:.|      |.....:..||   .:||....|..::.:|.....:||.
Mouse   350 --------KTLPTVPFKTKD------PPGMFGKLGVLLRRVTRNLMRNKQAVIMRLVQNLIMGLF 400

  Fly   770 LMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFG---------ALNSFPSEREVVSKERRS 825
            |:     |.|.|.:.  :.|:|.:  .....:|:.|.|         |:|.||..|.|..:|.:.
Mouse   401 LI-----FYLLRVQN--NTLKGAV--QDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQD 456

  Fly   826 GAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGC-TSLKLFFLMLIFLLINTIVAQSVGFFI 889
            |.|......||.:...||..:....::..:.|..||. ..:..|......||...::.:.:...:
Mouse   457 GLYHKWQMLLAYVLHVLPFSVIATVIFSSVCYWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVL 521

  Fly   890 GACCMDMNVSITLSALYTLATQLFG-GYLSS--RIPEGLSWIRYTSMIHYAYQNMQILEFREGAA 951
            .....:.|:..::.||.:::..|.| |::.:  .:|..|..:.|.:...|..:.:.:.|| .|..
Mouse   522 LGIVQNPNIVNSIVALLSISGLLIGSGFIRNIQEMPIPLKILGYFTFQKYCCEILVVNEF-YGLN 585

  Fly   952 IGCG----SPSSYEICK-QQSTEFIPYEEILKAQNSTSPLWLNTLILMMFFLVFRCLGYAVLR 1009
            ..||    |..::.:|. .|..:||.    .....:||....|.|||..|......||..:.:
Mouse   586 FTCGGSNTSMLNHPMCAITQGVQFIE----KTCPGATSRFTANFLILYGFIPALVILGIVIFK 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	3a01204	363..1009	CDD:273361	171/694 (25%)
Abcg5	NP_114090.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		ABCG_White	50..276	CDD:213201	80/227 (35%)
		3a01204	61..646	CDD:273361	171/686 (25%)