DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E23 and Abcg2

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_001342406.1	Gene:	Abcg2 / 26357	MGIID:	1347061	Length:	657	Species:	Mus musculus

Alignment Length:	673	Identity:	195/673 - (28%)
Similarity:	318/673 - (47%)	Gaps:	101/673 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 ERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHID--SGSVFLNREPLTKKWRRRIGY 426
            |::||||::|.:.| .:.||:||:|.||::|||.|:.::...  ||.|.:|..|....::...||
Mouse    59 EKEILSDINGIMKP-GLNAILGPTGGGKSSLLDVLAARKDPKGLSGDVLINGAPQPAHFKCCSGY 122

  Fly   427 VLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSG 491
            |:|:::....||:||.:.::|.||||.:|...||..:::.|::.|.|.....:|.|....||:||
Mouse   123 VVQDDVVMGTLTVRENLQFSAALRLPTTMKNHEKNERINTIIKELGLEKVADSKVGTQFIRGISG 187

  Fly   492 GEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHM 556
            ||:||.:|..||:|:|.::.|||||:||||.:|.:::.:|||.:: :.:||:.|:|||...:|.:
Mouse   188 GERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK-QGRTIIFSIHQPRYSIFKL 251

  Fly   557 FDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESHG 621
            ||.|.||..|:..:.|..|....:|...|...:|:.|||||.|:.:..             :|..
Mouse   252 FDSLTLLASGKLVFHGPAQKALEYFASAGYHCEPYNNPADFFLDVING-------------DSSA 303

  Fly   622 NYLNRNCITSSHHNQVSVS--GAKGKKQADSILIDDIINN-YYNQRSNRHHHQYENLHHTSNGCR 683
            ..|||    ....|:.:.:  .:||:|.....|.:..||: .|.:                  .:
Mouse   304 VMLNR----EEQDNEANKTEEPSKGEKPVIENLSEFYINSAIYGE------------------TK 346

  Fly   684 VEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSSRN 748
            .|.|:..                          .|....|.||..:.: |.|||..|...::.|:
Mouse   347 AELDQLP--------------------------GAQEKKGTSAFKEPV-YVTSFCHQLRWIARRS 384

  Fly   749 FRE--AKPRMLSKLNWFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNS 811
            |:.  ..|: .|......|:.|.|:.|||:|.|......:.:..|.:||..|. ..|:...|:..
Mouse   385 FKNLLGNPQ-ASVAQLIVTVILGLIIGAIYFDLKYDAAGMQNRAGVLFFLTTN-QCFSSVSAVEL 447

  Fly   812 FPSEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTV-YLMISYPMLGC-TSLKLFFLMLIF 874
            |..|:::...|..||.||:|:|:..|:.::|..:..||:| :..|.|.|||. .::..||:|:..
Mouse   448 FVVEKKLFIHEYISGYYRVSSYFFGKVMSDLLPMRFLPSVIFTCILYFMLGLKKTVDAFFIMMFT 512

  Fly   875 LLINTIVAQSVGFFIGACCMDMNVSITLSALYTLATQLFGGYLSS--RIPEGLSWIRYTSMIHYA 937
            |::....|.|:...|......::|:..|..:..:...||.|.|.:  .|...|||::|.|:..|.
Mouse   513 LIMVAYTASSMALAIATGQSVVSVATLLMTIAFVFMMLFSGLLVNLRTIGPWLSWLQYFSIPRYG 577

  Fly   938 YQNMQI-----LEFREGAAIGCGSP--SSYEICK------QQSTEFIPYEEILKAQNSTSPLWLN 989
            :..:|.     .||..|..:...|.  :||.||.      .|..|..|:           .||.|
Mouse   578 FTALQYNEFLGQEFCPGFNVTDNSTCVNSYAICTGNEYLINQGIELSPW-----------GLWKN 631

  Fly   990 TLILMMFFLVFRCLGYAVLRFLR 1012
            .:.|....::|..:.|..|.||:
Mouse   632 HVALACMIIIFLTIAYLKLLFLK 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	83/209 (40%)
		3a01204	363..1009	CDD:273361	192/668 (29%)
		ABC2_membrane	744..943	CDD:279410	57/204 (28%)
Abcg2	NP_001342406.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
Abcg2	NP_001342406.1	3a01204	46..651	CDD:273361	192/668 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51839
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730