Protein Alignment E23 and Abcg4

DIOPT Version :9

• Sequence 1: NP_524648.3
• Gene: E23 / 43895
• FlyBaseID: FBgn0020445
• Length: 1017
• Species: Drosophila melanogaster
• Sequence 2: NP_620405.3
• Gene: Abcg4 / 192663
• MGIID: 1890594
• Length: 646
• Species: Mus musculus
• Alignment Length: 719
• Identity: 194/719 - (26%)
• Similarity: 318/719 - (44%)
• Gaps: 125/719 - (17%)

  Fly   309 PASLSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLHNE--------- 364
            |..|:.|.:|......:.|..      ||.|       .:.::.:.|..|:....|
Mouse    30 PPVLTTHLKKVENHITEAQRF------SHLP-------KRSAVDIEFVELSYSVREGPCWRKRGY 81

  Fly   365 RQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHID-SGSVFLNREPL-TKKWRRRIGYV 427
            :.:|..:||.....|::.||||||:||:|.::.|:|.|... .|.:.:|..|. .:.:|:...|:
Mouse    82 KTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCYI 146

  Fly   428 LQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGG 492
            :|:::..|.||:.|.::.:|.|:|.|.  :..|...|..||.||.|..|..|:     ...||||
Mouse   147 MQDDMLLPHLTVLEAMMVSANLKLSEK--QEVKKELVTEILTALGLMSCSHTR-----TALLSGG 204

  Fly   493 EKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMF 557
            ::||..||.||:.||.:|..|||||||||.|...::.::|..|. ..:|::.::||||:::|.||
Mouse   205 QRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAH-GGRTVICTIHQPSAKLFEMF 268

  Fly   558 DKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLK-SHPDIREKLFIAAKESHG 621
            |||.:|.||:..:.|.|.|:..:.:.:|:....::|||||::|... .:.|:...||.|.:
Mouse   269 DKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRAVQ---- 329

  Fly   622 NYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCRVEE 686
               |..|      .......:.||
Mouse   330 ---NGLC------TMAEKKSSPGK----------------------------------------- 344

  Fly   687 DEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSSRNFRE 751
             .|...|...|..:..       ..:.|:::                 ||..||||:|..|.|..
Mouse   345 -NELPAHCPTCPPELD-------PIESHTFA-----------------TSTLTQFCILFRRTFLS 384

  Fly   752 -AKPRMLSKLNWFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSFPSE 815
             .:..:|:.|.:...:.:.::.|.::..:......:.:..|::|||..:.|..||...:.:||.|
Mouse   385 ILRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDASKVFNNTGFLFFSMLFLMFAALMPTVLTFPLE 449

  Fly   816 REVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCTSLKLFFLMLIFLLINT- 879
            ..|..:|..:..|.|.||||||..|::|..:..|.||..|.|.|.|..:....||:...|.|.|
Mouse   450 MAVFMREHLNYWYTLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALAIATA 514

  Fly   880 IVAQSVGFFIGACCMDMNVSITLSALYTLATQLFGGYLSS--RIPEGLSWIRYTSMIHYAYQNMQ 942
            :||||:|..|||....:.|:..:..:..:...||.|:..|  .||..|.|..|.|.:.|.::.:.
Mouse   515 LVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGLI 579

  Fly   943 ILEFREGAAIGCGSPSSYEICKQQSTEFIPYEEILKAQN-STSPLWLNTLILMMFFLVFRCLGYA 1006
            :..:        |....:..|..:...|...:.||:..: ..:.|:::.|:|.:|||..|.|.|.
Mouse   580 LTIY--------GMERGHLTCLDEQCPFRDPQIILRELDVEEAKLYMDFLVLGIFFLALRLLAYL 636

  Fly  1007 VLRF 1010
            |||:
Mouse   637 VLRY 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	81/232 (35%)
		3a01204	363..1009	CDD:273361	182/662 (27%)
		ABC2_membrane	744..943	CDD:279410	60/202 (30%)
Abcg4	NP_620405.3	3a01204	44..646	CDD:273361	190/705 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710