DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E23 and abcx-1

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_495321.3	Gene:	abcx-1 / 183860	WormBaseID:	WBGene00006522	Length:	710	Species:	Caenorhabditis elegans

Alignment Length:	776	Identity:	150/776 - (19%)
Similarity:	276/776 - (35%)	Gaps:	265/776 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 DAKSNSPASLSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQPQHSL----------QLTFQN 357
            |.:|:...|:.:    |...::..:|...::.|     |::||:.:..:          |.|...
Worm    13 DDESSGRDSIYF----STIRSRHAEHFFADMQN-----HNTQNEKKGIIRYLEYYEINSQSTRPY 68

  Fly   358 LNVLHNE---------------------RQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQ 401
            .|:|.|:                     :|.:.::|..:|..:|||||....|...:||..:.|.
Worm    69 PNLLLNKLSFSKDLRSSSDKVLLRLPVLKQEVHNISFELSSSDVLAIMYTKESETISLLKIICGI 133

  Fly   402 RHID---SGSVFLNREPLTK-KWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESM--PRAEK 460
            :.:.   ||.:.:|...::: :..:.||:|..|.   |..||.    ....|.:..:.  |..|:
Worm   134 KDVRGKLSGDILVNGHRMSRDRLEKTIGFVSLES---PTSTLS----VRQYLHVHGNFYPPMTER 191

  Fly   461 MRQVDHILEAL--ELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHS 523
            ...|.|::..|  :||.   ....|.:...|:..:.:|..:|.:|:.:|.:::..:....:|.|.
Worm   192 YGGVGHLINKLMTDLGL---FPVSDIICSRLNRSQWQRVKVASQLVRDPTILVCSDIFKDIDVHD 253

  Fly   524 AISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTI 588
            ...|:..|:.:|....:.:::::...|.|:.:||.|.::|..||..|||..:::.::||.||...
Worm   254 QCFLIDYLREWAVKTNRIVIMAISPTSLQILNMFSKAMILASGRMIYFGPPKSMQQYFETIGCPC 318

  Fly   589 KPHYNPADFVLEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILI 653
            .|:.|..|:.:: |.:|.::...   |::||                              |:.|
Worm   319 PPYKNVCDYYVD-LVTHDNLTSD---ASRES------------------------------SVRI 349

  Fly   654 DDIINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSA 718
            ..::|. :||.:       ..:..|::|..:
Worm   350 ARLVNK-WNQTA-------PPVRRTASGKFL---------------------------------- 372

  Fly   719 GSGPGHSADDDWLSYPTS--FHTQFCVLSSRNFREAKPRMLSKLNWFQTIGLALMAGAIWFQLPR 781
                        |..||:  |.....::|              |.||..|.  ..|..|:|.|
Worm   373 ------------LDLPTAGIFMNLLTLIS--------------LFWFNFIN--NRASRIFFLL-- 407

  Fly   782 TEEFLHDLQGWM--------------FFSQTYWMLFALF------GALN----SFPSERE----- 817
               |:..|...:              |.::..::...:|      |.:|    :|.||.:
Worm   408 ---FIFSLSTCLSLHLSDLSLTLPDAFLNRNSYLELLIFYVPLFIGLVNLKKCTFLSEFDKFYLF 469

  Fly   818 VVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCTSLKLFFLMLIFL------- 875
            :.::.......:||.  |..||:.|.::|    |..::..|.|..||:.....|.||.
Worm   470 ISARHHLKELLKLSP--LKNMCSSLSIII----VSFVVELPFLLITSMVFAMPMSIFTDFHQKSS 528

  Fly   876 -LINTIVAQSVGFFIGACCMDMNVSITLSALYTLATQLFGGYLSSRIPEGLSW----IRYTSMIH 935
             .:.::|:.|..|||       |:|:         |||....:|:...|.||:    |.:.|:.
Worm   529 NHLTSLVSISSSFFI-------NLSV---------TQLVVNSVSNLSSEPLSFFFFVISWFSLF- 576

  Fly   936 YAYQNMQILEFREGAAIGCGSPSSYEICKQQSTEFIPYEEILKAQNSTSPLWLNTLILMMF 996
                            ..||.|             .|...|||..|   ||:..|..:..|
Worm   577 ----------------FACGFP-------------FPIHSILKYFN---PLFFPTTSVFRF 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	55/260 (21%)
		3a01204	363..1009	CDD:273361	137/706 (19%)
		ABC2_membrane	744..943	CDD:279410	49/239 (21%)
abcx-1	NP_495321.3	P-loop_NTPase	102..302	CDD:304359	49/209 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820