DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and wht-5

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_502352.1	Gene:	wht-5 / 178182	WormBaseID:	WBGene00008950	Length:	695	Species:	Caenorhabditis elegans

Alignment Length:	823	Identity:	213/823 - (25%)
Similarity:	355/823 - (43%)	Gaps:	193/823 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 AASVASPPATSDATAATS--VASSDSSASSSASSTS----------SSSSSSTSSEFTHTSQT-T 280
            |..:..|....|....||  |..:..|.|.:...|.          :|.......|..|:|:. .
Worm     8 AEPLLKPKNVEDEGLITSLDVDPTQKSRSPTPKPTPIPVLINDTPVASEIEQVEKELAHSSERFR 72

  Fly   281 IPSTDNLTSSNGLANIGKSILVDAKSNSPASLSYHFEKSAAANQQKQHHNINICNSHHPHHHSQN 345
            .|.|.::|:....|.|...:..:||
Worm    73 KPKTLSVTNDTESARIPSQVKTNAK---------------------------------------- 97

  Fly   346 QPQHSLQLTFQNLN--VLHNE---RQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQ--RH 403
                  :|.|||:.  ||..:   ::||..:.|...|.|:..|||.||:||||||:.|:|:  ::
Worm    98 ------KLVFQNIQAVVLKKKGVRQEILKKIDGVARPGELTFIMGSSGAGKTTLLNILTGRNLKN 156

  Fly   404 IDS-GSVFLN-REPLTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDH 466
            |:: |.:.:| |..::.:.::...||.|:::|...||:|||:.:.|.||.|.::...|....||.
Worm   157 IETDGDIMINGRNMISNEMKKLSAYVQQDDVFIGTLTVRETLRFAAKLRSPSALGATELDSIVDE 221

  Fly   467 ILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVL 531
            :|..:.|..|:.||.|....:.||.||:||...|||:||:|.::..|||||||||..:..::|.|
Worm   222 LLVMMSLKKCENTKVGTMTEKSLSRGERKRLAFACEILTDPPILFCDEPTSGLDSFMSHQVIKAL 286

  Fly   532 KRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPAD 596
             |...:|.||::.::||||:.::||.|:|:||.||..||.|..:.:...|...|
Worm   287 -RQLTIEGKTVICTIHQPSTSVYHMADQLILLSQGHVAYAGPAKQVDAFFGRCG----------- 339

  Fly   597 FVLEQLKSHPD-----IREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILID-D 655
            :.:.:..|.||     |..|.|    |:..:|                     .|:.:.|::: |
Worm   340 YPIPKFVSSPDHFMRVISHKSF----ETEDDY---------------------NKRIEKIVLEHD 379

  Fly   656 IINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGS 720
            |:.            :.::.|.|.:..|.|..|.|.
Worm   380 IMK------------KEQSTHSTLSSSRREHPETAP----------------------------- 403

  Fly   721 GPGHSADDDWLSYPTSFHTQFCVLSSRN----FREAKPRMLSKLNWFQTIGLALMAGAIWFQLPR 781
                      .::|.::..||..:..|:    :|| :..:|.||  .||:.:::|.|:.::.|..
Worm   404 ----------FTFPRTWTAQFFFIFQRSSIQLWRE-RSVLLVKL--IQTLIMSIMIGSTYYGLEI 455

  Fly   782 TEEFLHDLQGWMFFS-QTYWMLFALFGALNSFPSEREVVSKERRSGAYRLSAYYLAKMCAELPLV 845
            .::.|...:|:.|.| |...||| :..|:..|..:..||.:|.::..|..|||||||..|:....
Worm   456 DKKSLPSFKGFAFVSVQMMHMLF-MMPAMTVFWKDYPVVVREFQANMYSPSAYYLAKTTADSIQY 519

  Fly   846 ITLPTVYLMISYPMLGCTSLKLFFLMLI-FLLINTIV---AQSVGFFIGACCMDMNVSITLSALY 906
            :..|.::..|   :||.|||....:::. :|:||.::   |.|||....|.|..:...:|:..:.
Worm   520 LVFPVIFSGI---LLGMTSLPYSVVIITNYLIINILLSLNACSVGQSFAAMCGHLATGMTVLPIV 581

  Fly   907 TLATQLFGGYLSSRIPEGLSW----IRYTSMIHYAYQNMQILEFREGAAI-GCGSPSSYEICK-- 964
            .:...:|||::.:.  |.:.|    ..:.|...|.::.:.|:.|...:.| ||.|.||....|
Worm   582 CVPLMVFGGFMITY--EAIPWYFLPFAWVSWYKYGFEAITIVYFNHNSTISGCESNSSVATLKMS 644

  Fly   965 --QQSTEFIPYEEILKAQN-STSPLWLNTLILMMFFLVFRCLG 1004
              ...|..|   |.:|||. ..:.|||:..:::...|.::.||
Worm   645 IDSNCTTGI---EFIKAQAFEETHLWLDYTVILAVILFWKILG 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	91/230 (40%)
		3a01204	363..1009	CDD:273361	187/674 (28%)
		ABC2_membrane	744..943	CDD:279410	57/211 (27%)
wht-5	NP_502352.1	3a01204	88..695	CDD:273361	196/743 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720