DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and wht-3

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_497825.2	Gene:	wht-3 / 175528	WormBaseID:	WBGene00007631	Length:	614	Species:	Caenorhabditis elegans

Alignment Length:	684	Identity:	167/684 - (24%)
Similarity:	308/684 - (45%)	Gaps:	133/684 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 LQLTFQNLNV-------LHNERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLD---CLSGQRHID 405
            :.:|::|:.|       ...::|:|:.|||...|.|::|:||.||:|||||::   |.:.:....
Worm    37 ITVTWENIEVKTRKKLFSKKQKQLLNRVSGIAKPGEMVALMGASGAGKTTLMNVLMCRNMKGLEK 101

  Fly   406 SGSVFLNREPLTKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEA 470
            :|:|.:|...:.|:.....|:..|:|||.|.||:.|.::..|.||:..:  :..:..:||.|:|.
Worm   102 NGTVKVNGTKIGKEISLISGFAQQQEIFIPTLTVDEYLMIQARLRMKAN--KHTRRERVDEIIEM 164

  Fly   471 LELGCCQQTKFG-DYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRY 534
            |.|..|:..|.| ..|.:|:||||.:|...|||||:||.|:..|||||||||..|.|::::||..
Worm   165 LRLQNCRDLKIGTPGLVKGISGGEARRLTFACELLSNPSLLFADEPTSGLDSFMAASVVQILKNL 229

  Fly   535 AQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVL 599
            |. ..:|:   :|||::::|..|||::.|..|:||:.|......:.|.|.|..|...:||.:::.
Worm   230 AN-SGRTL---IHQPTAELFFQFDKIIFLSMGKTAFMGTPHESVKFFADCGHPIPKLFNPPEWIQ 290

  Fly   600 EQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQR 664
            .:|...|:...|    ::|:.|.                                 ||..|  ::
Worm   291 SKLSVIPNNETK----SRETIGK---------------------------------IIEFY--EK 316

  Fly   665 SNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSADDD 729
            |..|......:       ||....|...::                         ..||..|:..
Worm   317 SIIHQKSIVEI-------RVIATTELPPYI-------------------------ENPGFFAETG 349

  Fly   730 WLSYPTSFHTQFCVLSSRNFREAKPRMLSKLNWFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMF 794
            .|.      .:.|:...|:..:.:.:::.|      :.:.|..|::::|.|.....:.:....::
Worm   350 ALL------KRACLDVIRSPAQMRMKLIQK------VVMGLFIGSLYWQQPLDPRGVRNTNSALY 402

  Fly   795 FSQTYWMLFALFGALNSFPSEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPM 859
            |.........:||.:.....|..::::|...|.:.:.:||:::..:.|||......:.::|||.|
Worm   403 FLIAELTFSTMFGIMTFMEHELPLIAREYHDGLFYVISYYISRFLSYLPLFTIDGALMIVISYWM 467

  Fly   860 LGCTSLKLFFLMLIFLLINTIVAQSV---GFFIGACCMD-----MNVSITLSALYTLATQLFGGY 916
            :|..|  .:..:...:||:.:|.||.   |.|: ||..:     :..::..|.|:.|.:.|:|.
Worm   468 IGLNS--TWQQVAKSILISVLVEQSATSCGLFL-ACLFETTSLAIAFAVPASGLFALLSGLYGN- 528

  Fly   917 LSSRIPEGLSWIRYTSMIHYAYQNMQILEFREGAAIGCGSPSSYEICKQQSTEFIP-YEEILKAQ 980
             ::..|..:.|:::||...|.::.:.:.::.:                ..:.::.| |.|::..|
Worm   529 -TNNFPVYIRWMQWTSWCRYGFEGLVVNQWSQ----------------VDNPKWDPFYRELILKQ 576

  Fly   981 NSTSP--LWLNTLILMMFFLVFRCLGYAVLRFLR 1012
            .|.:.  ..|:.:.|....:.|...||..| |:|
Worm   577 FSFNKDNYQLDVIGLCSIVIFFYLAGYIAL-FIR 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	87/231 (38%)
		3a01204	363..1009	CDD:273361	161/660 (24%)
		ABC2_membrane	744..943	CDD:279410	42/206 (20%)
wht-3	NP_497825.2	ABCG_EPDR	36..263	CDD:213180	87/231 (38%)
		3a01204	37..614	CDD:273361	167/684 (24%)
		ABC2_membrane	351..555	CDD:279410	44/220 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720