DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E23 and Abcg8

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_569098.2	Gene:	Abcg8 / 155192	RGDID:	620300	Length:	672	Species:	Rattus norvegicus

Alignment Length:	815	Identity:	194/815 - (23%)
Similarity:	330/815 - (40%)	Gaps:	226/815 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 SSSASSTSSSSSSSTSSEFTHTSQTTIPSTDNLTSSNGLANIGKSILVDAKSNSPASLSYHFEKS 319
            :||...:..||.|..|..||::.|:......:||..           ||..|..|     .||:.
  Rat    20 ASSLQDSVFSSESDNSLYFTYSGQSNTLEVRDLTYQ-----------VDMASQVP-----WFEQL 68

  Fly   320 AAANQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLHNERQILSDVSGFVSPCEVLAIM 384
            |......:...                .|.|..|..:||             |..|...::|||:
  Rat    69 AQFKLPWRSRG----------------SQDSWDLGIRNL-------------SFKVRSGQMLAII 104

  Fly   385 GPSGSGKTTLLDCLSGQRH---IDSGSVFLNREPLTKKW-RRRIGYVLQEEIFFPQLTLRETVVY 445
            |.:|.|:.||||.::|:.|   :.||.:::|.:|.|.:. ::.:.:|.|::...|.||:|||:.:
  Rat   105 GSAGCGRATLLDVITGRDHGGKMKSGQIWINGQPSTPQLIQKCVAHVRQQDQLLPNLTVRETLTF 169

  Fly   446 TALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLM 510
            .|.:|||::..:|::.::|:.::..|.|..|..|:.|:...||:||||::|.:|..:||.||.::
  Rat   170 IAQMRLPKTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGIL 234

  Fly   511 LLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQ 575
            :||||||||||.:|.:|::.|.|.|: ..:.::||:|||.|.:|.:||.:||:..|...|.|..|
  Rat   235 ILDEPTSGLDSFTAHNLVRTLSRLAK-GNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGVAQ 298

  Fly   576 NIYRHFEDIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVS 640
            ::.::|..||.....:.|||||                         |::...|......|...:
  Rat   299 HMVQYFTSIGYPCPRYSNPADF-------------------------YVDLTSIDRRSKEQEVAT 338

  Fly   641 GAKGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQS-- 703
            ..|.:..|...|                                 |..:.....:| .|:::|
  Rat   339 MEKARLLAALFL---------------------------------EKVQGFDDFLW-KAEAKSLD 369

  Fly   704 ----NFSSCASSDCHSYSAGSGPG----------HSADDDWLSYPTSF-H-TQFCVLSSRNFREA 752
                ..|...:.|.:..:|...||          ....:|:...||.| | .:.|::|
  Rat   370 TGTYAVSQTLTQDTNCGTAAELPGMIQQFTTLIRRQISNDFRDLPTLFIHGAEACLMS------- 427

  Fly   753 KPRMLSKLNWFQTIGLALMAGAIWF-QLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSF---- 812
                             |:.|.::: ...:...|: |:...:|          :.|||..|
  Rat   428 -----------------LIIGFLYYGHADKPLSFM-DMAALLF----------MIGALIPFNVIL 464

  Fly   813 ------PSEREVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCTSLK----L 867
                  .|||.::..|...|.|....|:.||:..|||.......:|.|   |:...|:|:    |
  Rat   465 DVVSKCHSERSLLYYELEDGLYTAGPYFFAKVLGELPEHCAYVIIYGM---PIYWLTNLRPGPEL 526

  Fly   868 FFL--MLIFLLINTIVAQSVGFFIGACCMDMNV------------SITLSALYTLATQLFGGYLS 918
            |.|  ||::|::             .||..|.:            |...:|||. :..|..|::.
  Rat   527 FLLHFMLLWLVV-------------FCCRTMALAASAMLPTFHMSSFCCNALYN-SFYLTAGFMI 577

  Fly   919 SR-----IPEGLSWIRYTSMIHYAYQNMQILEFREGAAIGCGSPSSYEICKQQSTEFIPYEEILK 978
            :.     :|   :||...|.:.:.:..:..::|.       |...:.:|  ...|..:|.:.::.
  Rat   578 NLNNLWIVP---AWISKMSFLRWCFSGLMQIQFN-------GHIYTTQI--GNLTFSVPGDAMVT 630

  Fly   979 AQNSTS-PLWLNTLILMMFFLVFRCLGYAVLRFLR 1012
            |.:..| ||:...||::.....|..|.|..|:|::
  Rat   631 AMDLNSHPLYAIYLIVIGISCGFLSLYYLSLKFIK 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	82/225 (36%)
		3a01204	363..1009	CDD:273361	169/702 (24%)
		ABC2_membrane	744..943	CDD:279410	46/232 (20%)
Abcg8	NP_569098.2	ABCG_White	60..295	CDD:213201	88/269 (33%)
		3a01204	88..662	CDD:273361	171/710 (24%)
		ABC2_membrane	401..605	CDD:279410	52/258 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6143
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	LDO	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920