DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and Abcg5

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_446206.2	Gene:	Abcg5 / 114628	RGDID:	620298	Length:	652	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	183/788 - (23%)
Similarity:	307/788 - (38%)	Gaps:	193/788 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 SSSASSTSSSSSSSTSSEFTHTSQTTIPSTDNLTSSNGLANIGKSILVDAKSNSPASLSYHFEKS 319
            ::..|.:|....|.|.||..|              |.|:.|:..|:
  Rat    17 NNRGSQSSLEEGSVTGSEARH--------------SLGVLNVSFSV------------------- 48

  Fly   320 AAANQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLHNERQILSDVSGFVSPCEVLAIM 384
              :|:.....||..|....                         :|:||.|||.::...:.:.|:
  Rat    49 --SNRVGPWWNIKSCQQKW-------------------------DRKILKDVSLYIESGQTMCIL 86

  Fly   385 GPSGSGKTTLLDCLSGQ-RHIDS--GSVFLNREPLTK-KWRRRIGYVLQEEIFFPQLTLRETVVY 445
            |.||||||||||.:||: |...:  |.||:|...|.: :::..:.|:||.::|...||:|||:.|
  Rat    87 GSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQDCVSYLLQSDVFLSSLTVRETLRY 151

  Fly   446 TALLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLM 510
            ||:|.|..|...... ::|:.:|..|.|........|:|...|:|.||::|.:||.:||.:|.:|
  Rat   152 TAMLALRSSSADFYD-KKVEAVLTELSLSHVADQMIGNYNFGGISSGERRRVSIAAQLLQDPKVM 215

  Fly   511 LLDEPTSGLD----SHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYF 571
            :|||||:|||    :|..:.|:::.:|     .:.:::::|||.|::||.|||:.:|..|...:.
  Rat   216 MLDEPTTGLDCMTANHIVLLLVELARR-----NRIVIVTIHQPRSELFHHFDKIAILTYGELVFC 275

  Fly   572 GDVQNIYRHFEDIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQ 636
            |..:.:...|.:.|.....|.||.||.::........||:
  Rat   276 GTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDTQSRER------------------------- 315

  Fly   637 VSVSGAKGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGC-RVEEDEEAAQHLVWCAAD 700
                               .|..|      :.....|:....|:.| ::.|:.|..:||
  Rat   316 -------------------EIETY------KRVQMLESAFRQSDICHKILENIERTRHL------ 349

  Fly   701 SQSNFSSCASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLS------SRNFREAKPRMLSK 759
                    .:.....:...:.||                .||.|.      :||....|..::.:
  Rat   350 --------KTLPMVPFKTKNPPG----------------MFCKLGVLLRRVTRNLMRNKQVVIMR 390

  Fly   760 LNWFQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFG---------ALNSFPSE 815
            |.....:||.|:     |.|.|.:..:  |:|.:  .....:|:.|.|         |:|.||..
  Rat   391 LVQNLIMGLFLI-----FYLLRVQNNM--LKGAV--QDRVGLLYQLVGATPYTGMLNAVNLFPML 446

  Fly   816 REVVSKERRSGAYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGC-TSLKLFFLMLIFLLINT 879
            |.|..:|.:.|.|:.....||.:...||..|....::..:.|..||. ..:..|......||...
  Rat   447 RAVSDQESQDGLYQKWQMLLAYVLHALPFSIVATVIFSSVCYWTLGLYPEVARFGYFSAALLAPH 511

  Fly   880 IVAQSVGFFIGACCMDMNVSITLSALYTLATQLFG-GYLSS--RIPEGLSWIRYTSMIHYAYQNM 941
            ::.:.:...:.....:.|:..::.||.:::..|.| |::.:  .:|..|..:.|.:...|..:.:
  Rat   512 LIGEFLTLVLLGMVQNPNIVNSIVALLSISGLLIGSGFIRNIEEMPIPLKILGYFTFQKYCCEIL 576

  Fly   942 QILEFREGAAIGCGS-----PSSYEICKQQSTEFIPYEEILKAQNSTSPLWLNTLILMMFFLVFR 1001
            .:.|| .|....||.     |::......|..:||.    .....:||....|.|||..|.....
  Rat   577 VVNEF-YGLNFTCGGSNTSVPNNPMCSMTQGIQFIE----KTCPGATSRFTTNFLILYSFIPTLV 636

  Fly  1002 CLGYAVLR 1009
            .||..|.:
  Rat   637 ILGMVVFK 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	80/229 (35%)
		3a01204	363..1009	CDD:273361	168/678 (25%)
		ABC2_membrane	744..943	CDD:279410	46/217 (21%)
Abcg5	NP_446206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		2/12 (17%)
		ABCG_White	50..276	CDD:213201	84/256 (33%)
		3a01204	61..646	CDD:273361	169/709 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910