DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E23 and abcg8

DIOPT Version :9

Sequence 1:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster
Sequence 2:	NP_001108041.2	Gene:	abcg8 / 100136850	ZFINID:	ZDB-GENE-050517-41	Length:	684	Species:	Danio rerio

Alignment Length:	789	Identity:	202/789 - (25%)
Similarity:	342/789 - (43%)	Gaps:	147/789 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 ASSTSSSSSSSTSSEFTHTSQTTIPSTDNLTSSNGLANIGKSILVDAKSNSPASLSYHFEKSAAA 322
            :..|...|..|.||.:....:..:|....          |:.||.   |:.....|.:|..|...
Zfish     2 SDDTVFHSGESFSSSYEKQIKVALPQNTQ----------GRDILF---SSPEEDSSLYFTYSGGR 53

  Fly   323 NQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLHNERQ-ILSDVSGFVSPCEVLAIMGP 386
            |:      :.:.|.::....:...|.:.....|:....:|:.:| ::.|::..|...::||::|.
Zfish    54 NE------LEVRNLNYEVDTAAQIPWYEKLSEFKMPWEMHSNKQTVIKDLNLHVHSGQMLAVIGS 112

  Fly   387 SGSGKTTLLD---CLSGQRHIDSGSVFLNREPLTKKW-RRRIGYVLQEEIFFPQLTLRETVVYTA 447
            ||.|||:|||   |......::||.:.:|.:|.|:.. ::.|.:|.|::...|.||:|||:.:.|
Zfish   113 SGCGKTSLLDIITCRDEGGSMNSGEILINGKPSTRSLVKKSIAHVRQDDRLLPHLTVRETLAFVA 177

  Fly   448 LLRLPESMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLL 512
            .||||.:..:.::.::||.::..|.|..|..|:.|:...||:||||::|.:||.:||.||.:::|
Zfish   178 KLRLPANFSQKQRDQRVDDVIAELRLRQCAHTRVGNEYVRGVSGGERRRVSIAVQLLWNPGILIL 242

  Fly   513 DEPTSGLDSHSAISLMKVLKRYAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNI 577
            |||||||||.:|.:|:..|.|.|: ..:.:::|||||.|.:|.:||.::||..|...|.|..:::
Zfish   243 DEPTSGLDSFTAHNLVITLYRLAR-GNRLVLLSVHQPRSDIFQLFDLVVLLSSGSAVYCGQAKDM 306

  Fly   578 YRHFEDIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGA 642
            ..:|..:|.....:.||:|:.::.:.......||             ...|:     .:.|:..|
Zfish   307 VSYFTTLGYPCPRYCNPSDYYVDLISIDRRTPEK-------------EAQCL-----EKASMLAA 353

  Fly   643 KGKKQADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSS 707
            :        .::.:.||             |:....|..|. ....||.|..|...:..:|..:.
Zfish   354 Q--------FLEKVKNN-------------EDFMWKSEVCG-PPALEAPQSSVPSVSMKESVITV 396

  Fly   708 CASSDCHSYSAGSGPGHSADDDWLSYPTSFHTQFCVLSSRN-FREAKPRMLSKLNWFQTIGLALM 771
            ....|                   ..|...| ||..|..|. |.:.:..:...::..:.:.::|:
Zfish   397 SKQKD-------------------QLPGKVH-QFTTLIRRQVFNDYRDLVTLVVHGLEALLMSLL 441

  Fly   772 AGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSFP----------SEREVVSKERRSG 826
            .|.::|..  |||.|.       ...|..:|: :.|||..|.          |||.::..|...|
Zfish   442 IGFLYFGC--TEEGLS-------IQDTVALLY-MIGALTPFAVVLDVIAKCHSERAMLYHELEDG 496

  Fly   827 AYRLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCTSLKLFFLMLIFLLI--NTIVAQSVGFFI 889
            .|.::.|:.||:..|||.......||.:..|.:.|.......|| |.|||:  ....::|:..|:
Zfish   497 MYSVTPYFFAKVLGELPEHCAFTLVYGVPIYWLAGLNVAPDRFL-LNFLLVWLTVYCSRSMALFV 560

  Fly   890 GACCMDMNVSITLSALYTLATQLFGG-------YLSSRIPEGL-------SWIRYTSMIHYAYQN 940
            .|            ||.||.|..|.|       ||::.....|       ||..|.|.:.:.::.
Zfish   561 AA------------ALPTLQTSSFMGNALFTVFYLTAGFVISLENMWMVASWFSYISFMRWGFEG 613

  Fly   941 MQILEFREGAAIGCGSPSSYEICKQQSTEF--IPYEEILKAQNSTSPLWLNTLILMMFFLVFRCL 1003
            |..::||     |...|.:   ....:.||  |...|::|.  :..||:...|:|:...|||..|
Zfish   614 MLQVQFR-----GTRIPIT---IGNLTVEFDGIKVVEMMKM--NQYPLFSCYLVLIAVSLVFILL 668

  Fly  1004 GYAVLRFLR 1012
            .|..|:|::
Zfish   669 YYLSLKFIK 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	84/226 (37%)
		3a01204	363..1009	CDD:273361	182/679 (27%)
		ABC2_membrane	744..943	CDD:279410	56/225 (25%)
abcg8	NP_001108041.2	3a01204	47..674	CDD:273361	189/726 (26%)
		ABCG_White	72..301	CDD:213201	85/229 (37%)
		ABC2_membrane	413..617	CDD:279410	56/226 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	LDO	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920