DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and FARP2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_011510535.1	Gene:	FARP2 / 9855	HGNCID:	16460	Length:	1061	Species:	Homo sapiens

Alignment Length:	1087	Identity:	215/1087 - (19%)
Similarity:	381/1087 - (35%)	Gaps:	284/1087 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   890 KGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLII-VDGAIMQPIPEHPKRDYIFCLSTAFGDAYL 953
            :.||:.|:....:.        |.:. .||:::: :......|.|...:.:|         ..||
Human    93 QSYWIWLEPMKPII--------RQIR-RPKNVVLRLAVKFFPPDPGQLQEEY---------TRYL 139

  Fly   954 FQAPCQVELENWVNSIHSACA---AAFARHRGKTGTLHLLQEEIFRLEKAIESDH-KLKHMAELQ 1014
            |    .::|:..:......||   ||..       |.||||.||...::.::.:| |:......|
Human   140 F----ALQLKRDLLEERLTCADTTAALL-------TSHLLQSEIGDYDETLDREHLKVNEYLPGQ 193

  Fly  1015 Q---SVVTDQETRHQIQT------QILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHV 1070
            |   ..:.:...:|..||      |:|:....|     |.:.:|.:|||.:.|  ...:..::|:
Human   194 QHCLEKILEFHQKHVGQTPAESDFQVLEIARKL-----EMYGIRFHMASDREG--TKIQLAVSHM 251

  Fly  1071 SRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQ--MN 1133
            .........|:..|..|........|...|:          |..|.:     .|..:.:::  :.
Human   252 GVLVFQGTTKINTFNWSKVRKLSFKRKRFLI----------KLHPEV-----HGPYQDTLEFLLG 301

  Fly  1134 SRDEPEKTFKVAMPDNAYSTVY-LRD-----AMSV-----EEFLASACARRNLNPMEHFVRVKKR 1187
            ||||.:..:|:.:   .|.|.: |.|     |.:|     ..|..|...::.|  :::|.....:
Human   302 SRDECKNFWKICV---EYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQL--VDYFKDSGMK 361

  Fly  1188 RDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDE 1252
            |        :|        |...|......::.| ..:|.:.::....|....|.       ...
Human   362 R--------IP--------YERRHSKTHTSVRAL-TADLPKQSISFPEGLRTPAS-------PSS 402

  Fly  1253 LCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDL 1317
            ...:.|.  ..|..:.:|:.:..:    :.:.::|..:.|::|...|.:|      .:....||.
Human   403 ANAFYSL--SPSTLVPSGLPEFKD----SSSSLTDPQVSYVKSPAAERRS------GAVAGGPDT 455

  Fly  1318 VGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPA 1382
            ....               |..||.:.         |.||.: |.....||.:..||.:  :.|
Human   456 PSAQ---------------PLGPPALQ---------PGPGLS-TKSPQPSPSSRKSPLS--LSP- 492

  Fly  1383 AMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPS 1447
              |.|:.:|              |..:.||    .||          ||..|...........|.
Human   493 --AFQVPLG--------------PAEQGSS----PLL----------SPVLSDAGGAGMDCEEPR 527

  Fly  1448 RQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQ 1512
            .:...|::...:|.|::.|||||:|.|..:...:...:.:|..:....:..||.||..|..|.|.
Human   528 HKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRG 592

  Fly  1513 FLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASH----------SKA 1567
            ||:.:|:.|.|....:|....|..:.    ||...|..:...|.::|:...|          :|.
Human   593 FLREVEQRLALWEGPSKAHTKGSHQR----IGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKR 653

  Fly  1568 QKVLHPNEGNHALQE--FLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHV 1630
            .|.|........||:  :|           .|.::|:|||||:|.|.|||:::.........::.
Human   654 CKKLEAVYKEFELQKVCYL-----------PLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYA 707

  Fly  1631 HLCEALKGMEKVA---EHINEMQRIHEEYGAIFDHLFRQH--QKSCKQPIDLSPGDLLYYGGVEW 1690
            ...:|||.:.:|.   :||                |.|..  ||..:...||...:.|...|.|:
Human   708 DCHDALKAITEVTTTLQHI----------------LIRLENLQKLTELQRDLVGIENLIAPGREF 756

  Fly  1691 LNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVT 1755
            :.........||||: ..|.|:|...:::..|          ||:..:.      .|.:.|:|:.
Human   757 IREGCLHKLTKKGLQ-QRMFFLFSDMLLYTSK----------GVAGTSH------FRIRGLLPLQ 804

  Fly  1756 EVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSI 1820
            .:.:........:|...|.:.|..:..  .::|..|::.||...:..::..:         |.:|
Human   805 GMLLIVLDPPVEESDNEWSVPHCFTIY--AAQKTIVVAASTRLEKEKWMLDL---------NSAI 858

  Fly  1821 PMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPK--QQITIVHGSHTLGKPKKKS--GSQRHS 1881
            .....||.:            :...||.:.....|:  .::::...|....:..:.|  |..:|.
Human   859 QAAKSGGDT------------APALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHR 911

  Fly  1882 AGNID----YDNLSGSQEADDLPPSVGVVHYASGH-------THGQQ 1917
            |....    |.|.|.|: ||.   |..|.:..||:       :||.|
Human   912 ANTTMHVCWYRNTSVSR-ADH---SAAVENQLSGYLLRKFKNSHGWQ 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	17/98 (17%)
		PH	873..974	CDD:278594	13/84 (15%)
		TIAM1_RBD	1141..1219	CDD:176413	15/88 (17%)
		PDZ_signaling	1221..1308	CDD:238492	12/86 (14%)
		RhoGEF	1456..1647	CDD:238091	53/205 (26%)
		PH2_Tiam1_2	1650..1823	CDD:269957	31/174 (18%)
		PH	1693..1812	CDD:278594	20/118 (17%)
FARP2	XP_011510535.1	B41	45..234	CDD:214604	36/174 (21%)
		FERM_C_FARP1-like	221..341	CDD:270014	27/144 (19%)
		FA	333..375	CDD:312314	9/59 (15%)
		Herpes_ICP4_C	358..>533	CDD:332854	42/268 (16%)
		RhoGEF	537..720	CDD:238091	51/197 (26%)
		PH1_FARP1-like	749..862	CDD:269928	25/140 (18%)
		PH2_FARP1-like	935..1032	CDD:270055	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910