DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and ARHGEF17

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_055601.2 Gene:ARHGEF17 / 9828 HGNCID:21726 Length:2063 Species:Homo sapiens


Alignment Length:1879 Identity:365/1879 - (19%)
Similarity:588/1879 - (31%) Gaps:699/1879 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   622 PGSNQRS--------PYP----LRRPNAKSSTLPLPPHR---PLSTIR----------------- 654
            |||.:.|        |.|    ...|..:|...|.||.|   ||:.:|                 
Human   136 PGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRP 200

  Fly   655 --DKER-DRDRDGYYSDRNELIRERERERDRGYLSDHN--SSF--SNSRCASCIGESAR------ 706
              .:|| .|..||.:|..   |..:.:...|...|..:  :|:  |.||.||...|...      
Human   201 QQQQERAQRPADGLHSWH---IFSQPQAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLP 262

  Fly   707 -AQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLR-------QD-------- 755
             ||...:..|..|||.....|.|           ||:   |...|.||       ||        
Human   263 GAQSPAYHGGHSSGSDDDRDGEG-----------GHR---WGGRPGLRPGSSLLDQDCRPDSDGL 313

  Fly   756 --SSLNDSGYKSARADSLEQRA---EFIR-------------QDSLRSEYLSDRESRYGIVQQAS 802
              ||:|.:|...:.......||   |.:|             |:.||.  :||.......|.:.|
Human   314 NLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLRP--MSDSVGGAFRVAKVS 376

  Fly   803 IESTDSRMCYLTSSEIS-DDDRMSLTTAVSDED-------------------DGESVMASPYKAK 847
            ..|      ||.|...| ...|.|.|..:.|:|                   .||.::.|..:.:
Human   377 FPS------YLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPSFGAGEGLLRSQARTR 435

  Fly   848 ATGTAASSFNCTGAVRKAGF--------------------LSVKKWLLRKKHQIELARKRGWKGY 892
            |.|...:|    .|:|..||                    |::..:|.....::.:.:..|..|.
Human   436 AKGPGGTS----RALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGSSGD 496

  Fly   893 WVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAI--MQPIPEHPKRDYIFCLSTAFGDAYLFQ 955
                :|:.    |.|.|:..|          ..|.:  ::|||                    ..
Human   497 ----RGSN----PLDGRDSPS----------AGGPVGQLEPIP--------------------IP 523

  Fly   956 APC----QVELENWVNSIHSA----CA-AAFARHRGKTGTLHLLQEEIFRLEKAIESD------- 1004
            ||.    :..|::...::..|    |: ...||...:|..|.....|:.......|.|       
Human   524 APASPGTRPTLKDLTATLRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQ 588

  Fly  1005 ----HKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQS---GELPN 1062
                .:.:.:.|..|.:...|:...........|..::.|....|..|....:||..   |..|.
Human   589 DQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPE 653

  Fly  1063 PKSL------LTHVSRPTKNT---LNKLGVFTVSSF--HAFICARSPSLLNNLLAGRGATKRR-- 1114
            |...      .|.:.||..::   .|..|..|..|.  .|.:...:|..       .||.:||  
Human   654 PPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPT-------PGALRRRRK 711

  Fly  1115 -PPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPM 1178
             ||    |.||.|    ::::.:..|          ||                           
Human   712 VPP----SGSGGS----ELSNGEAGE----------AY--------------------------- 731

  Fly  1179 EHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAEL 1243
                     |.:.|.   :|.|:                         :..|.|:..||||::.|
Human   732 ---------RSLSDP---IPQRH-------------------------RAATSEEPTGFSVDSNL 759

  Fly  1244 IENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMY---LESVLQ------- 1298
            :.:...:..|        ..:.||..|:..|..    :.::.|:....|   ::|::|       
Human   760 LGSLSPKTGL--------PATSAMDEGLTSGHS----DWSVGSEESKGYQEVIQSIVQGPGTLGR 812

  Fly  1299 -----------EEQSLS-------------------------MMMRSSRTEP--------PDLVG 1319
                       :::|||                         .|:..|.:||        |:..|
Human   813 VVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPG 877

  Fly  1320 IMRVTDDMIDSL--VCPPPPT-------DP---PVMSEEMI------------------------ 1348
            ..|.......:|  ..|||.|       ||   .::|..:|                        
Human   878 ATRSRAQSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQD 942

  Fly  1349 -TGLI--------------VPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVV 1398
             ||.:              |||     |...:..||    |.||...|.|:...          :
Human   943 QTGSLSRARPSSRHVRHASVPA-----TFMPIVVPE----PPTSVGPPVAVPEP----------I 988

  Fly  1399 GGLGVAKPTSRTSSFE------IENL---------------LKTAEQETRKSSPTGSVTSSVSTT 1442
            |....|.||.:..|.|      :.||               |..|...:.::.|         ..
Human   989 GFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAPPSAEAKP---------PE 1044

  Fly  1443 ALTPSRQLTDAEK--------LRK-VVMELVDTERTYVKHLNNLLEHYLEPMKR---ETFLSNAE 1495
            |..|:.:.|.|.|        :|| |.|.|:|||::||:.|..|::.|::|:|:   ......:.
Human  1045 AARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSL 1109

  Fly  1496 INALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHF------ 1554
            ::.:|..|.|::....|||:.:             .||.|..:....:|:..   |..|      
Human  1110 VDEIFDQIPELLEHHEQFLEQV-------------RHCMQTWHAQQKVGALL---VQSFSKDVLV 1158

  Fly  1555 KLYSSFCASHSKAQKVLH-PNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQM 1618
            .:||::..:...|:..:. ..|...|..:||.....:.:....|...:|||:|||.:|.||::.:
Human  1159 NIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDL 1223

  Fly  1619 RNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLL 1683
            ...|.....:|..|.||.:.:::|||.||:..|..||         .:......|.|:      .
Human  1224 LKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEE---------AERHARVLQEIE------A 1273

  Fly  1684 YYGGVEWLN--ISDFL------------GKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGV 1734
            :..|:|.|.  :..||            ||..:.|      |:|...:|  | ..|::|...:..
Human  1274 HIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSL------FLFTDLIV--C-TTLKRKSGSLRR 1329

  Fly  1735 SSKNATNEVEII----RYQVL--IPVTEVQV--RASSAKDMDSHFLWELIHLRSQLQRRSEKVYV 1791
            ||.:......:|    :|::|  :|:.:..:  .||.|.:.:        :::..:.|..|.:..
Human  1330 SSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRE--------NIQKAISRLDEDLTT 1386

  Fly  1792 LSNSTADFRNAFLKTIRQIIRESVRNMSIPMK-------------NFGGSSGSVSGHSSQGMGS- 1842
            |...:.  .:..|....|.:.:::|::|..|.             :|..:...:.....:|..| 
Human  1387 LGQMSK--LSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSY 1449

  Fly  1843 -MGYP------GNSQTLERPKQQITIVHGSHTLGKP---------KKKSGSQRHSAGNIDYDNLS 1891
             ..:|      |..|..:..|:::.   .|.:...|         |.:||.|...|.    ..|:
Human  1450 IFEFPHPDARLGFEQAFDEAKRKLA---SSKSCLDPEFLKAIPIMKTRSGMQFSCAA----PTLN 1507

  Fly  1892 GSQEADDLPPSVGVVHYASGHTHGQ------QMQPAGFRGRSKTVGDV--------TEITCSSPE 1942
            ...|..   |.|.|.: :.|:. ||      :.:|           ||        ..|.|....
Human  1508 SCPEPS---PEVWVCN-SDGYV-GQVCLLSLRAEP-----------DVEACIAVCSARILCIGAV 1556

  Fly  1943 PHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPP----PPIRQPHLHHHSSDIERIDPGTKSE 2003
            |..|                      |..| |||||    ||...|         |...|....|
Human  1557 PGLQ----------------------PRCH-REPPPSLRSPPETAP---------EPAGPELDVE 1589

  Fly  2004 GEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSP 2068
            ...|.:..|:   |..|..|         .|.:...||...:          .|.|.:  |.|.|
Human  1590 AAADEEAATL---AEPGPQP---------CLHISIAGSGLEM----------TPGLGE--GDPRP 1630

  Fly  2069 DESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSP 2127
            :....:|:|:..::. :.|..|...:|.|..:|...:.:|.|..::...:......|.|
Human  1631 ELVPFDSDSDDESSP-SPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEP 1688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 24/155 (15%)
PH 873..974 CDD:278594 16/110 (15%)
TIAM1_RBD 1141..1219 CDD:176413 6/77 (8%)
PDZ_signaling 1221..1308 CDD:238492 20/132 (15%)
RhoGEF 1456..1647 CDD:238091 52/201 (26%)
PH2_Tiam1_2 1650..1823 CDD:269957 35/194 (18%)
PH 1693..1812 CDD:278594 25/138 (18%)
ARHGEF17NP_055601.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..365 59/247 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..466 19/89 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..581 22/133 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 602..958 74/456 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1060 6/34 (18%)
RhoGEF 1070..1253 CDD:279015 51/198 (26%)
PH-like 1286..>1432 CDD:302622 28/164 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1564..1584 10/29 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1616..1719 16/86 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2036..2055
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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