DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and ARHGEF11

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_006711722.1 Gene:ARHGEF11 / 9826 HGNCID:14580 Length:1579 Species:Homo sapiens


Alignment Length:1956 Identity:366/1956 - (18%)
Similarity:626/1956 - (32%) Gaps:624/1956 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   531 DQSYGQQQSSGQHP---------QQQQGPPQRSSRHQHHHQQAPNVTPTPGSPTSRLLLEYEMH- 585
            |:|..::||....|         ......|:|.|  ..||:|..:.:.|.|.....::::.:.| 
Human    10 DRSASKKQSHLSSPIAAWLSSLSSLGDSAPERKS--PSHHRQPSDASETTGLVQRCVIIQKDQHG 72

  Fly   586 ----------------------LRNTLAKG---------MDAESYSLHTFEALLSQSMENLEFAE 619
                                  ::..:.:|         |...|..|...:.:.|.:...|....
Human    73 FGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLLG 137

  Fly   620 SLPGSN-----QRSPYPLRRPNAKSSTLPLPPHRP----------LSTIRDKERDRDRDGYYSDR 669
            |.|.|.     |:.|.|...|.. :|.:|.||..|          ...::|.|..:......  |
Human   138 SSPSSMGISGLQQDPSPAGAPRI-TSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQIL--R 199

  Fly   670 NELIRERERERDR--GYLSDHNSSFSNSRCASCIGESARAQ------WFRHSDGWRSGSSTIGSG 726
            | ::|:.|:|..|  ...|.:.:|....:.     |.||.:      ..:...|   ||..|...
Human   200 N-MLRQEEKELQRICEVYSRNPASLLEEQI-----EGARRRVTQLQLKIQQETG---GSVDILPL 255

  Fly   727 SGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDR 791
            .|.   |.|.|..|..     ||.|...||.| |||  :.|..||             ||.|.:|
Human   256 YGD---TSQRPSEGRL-----SLDSQEGDSGL-DSG--TERFPSL-------------SESLMNR 296

  Fly   792 ESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSF 856
            .|   ::....::|  .|...:..:.::...|...:.|.......:.|..||             
Human   297 NS---VLSDPGLDS--PRTSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSP------------- 343

  Fly   857 NCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHL 921
                          |..::..:...:       .||:  ...:.::|...:..:.|     |.||
Human   344 --------------KPLIIGPEEDYD-------PGYF--NNESDIIFQDLEKLKSR-----PAHL 380

  Fly   922 IIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGT 986
                |..::         |||  |.|.....||.                .||..:.:...|.. 
Human   381 ----GVFLR---------YIF--SQADPSPLLFY----------------LCAEVYQQASPKDS- 413

  Fly   987 LHLLQEEIFR--LEKAIESDHKLKHM--AELQQSVVTDQETRHQI-QTQILQWEENLERLHCEQF 1046
             ..|.::|:.  |||......|:..|  ||:...:...::.|..: :.|.....|..|::|  .:
Human   414 -RSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIH--DY 475

  Fly  1047 RLRCYMASLQSGELPNPKSLLTHVSRP------TKNTLNKLGVFTVSSFHAFICARSPSLLNNLL 1105
            |.:   .:|..|.|.....||.....|      .:..|..||.. :|.:.....|.....||..:
Human   476 RTK---RTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDI-LSKYEEDRSAPMDFALNTYM 536

  Fly  1106 AGRGATKR--RPPMLSRSNSGSSRRSMQMNSRDEP--EKTFKVAMPDNAYSTVYLRDAMSVEEFL 1166
            :..|...|  ||     ||:....:|.....:..|  .||.|             :.:.|.:|  
Human   537 SHAGIRLREARP-----SNTAEKAQSAPDKDKWLPFFPKTKK-------------QSSNSKKE-- 581

  Fly  1167 ASACARRNLNPMEHFVRVKKRRDMEDHNYFVP---------HRNDLIENYLHNHEFVEVCMKILY 1222
            ..|...:..||:..:  :.|.:......:.:|         :..::|:::.:|.::         
Human   582 KDALEDKKRNPILKY--IGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQY--------- 635

  Fly  1223 QVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIV-- 1285
              :......:::...|...:|:|:...:.|:  .:.|.|.         :||.|.|..:....  
Human   636 --DAPEPGTQRLSTGSFPEDLLESDSSRSEI--RLGRSES---------LKGREEMKRSRKAENV 687

  Fly  1286 ----SDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEE 1346
                ||:||.......:..||.|....|..|.                ||..|.||..|. |...
Human   688 PRSRSDVDMDAAAEATRLHQSASSSTSSLSTR----------------SLENPTPPFTPK-MGRR 735

  Fly  1347 MITGLIVPAPGW-------------NGTSKDLY-SPEAESSPATSFVDPAAMAAQLAVGGVGGVV 1397
            .|..   |:.|:             .|...||. .|:|::...|                ||..|
Human   736 SIES---PSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHT----------------VGKDV 781

  Fly  1398 VGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVME 1462
            |.||     |.|    ||:.                                       ::|:.|
Human   782 VAGL-----TQR----EIDR---------------------------------------QEVINE 798

  Fly  1463 LVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEP-- 1525
            |..||.::::.|..|...:.:.||:|..:...|:..||.|:.|::.....:.:.:::..:..|  
Human   799 LFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPII 863

  Fly  1526 ----DFNKFEHCGQFRNVLFAIGSAFLYY--------------VNHFKLYSSFCASHSKAQKVLH 1572
                |.......|..|..|..:.:.|..|              .:.|:|:.....||.:.:::  
Human   864 KEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRL-- 926

  Fly  1573 PNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALK 1637
                                   .|...:|..:||:.||||||:.:...|:....||..||.|..
Human   927 -----------------------QLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARD 968

  Fly  1638 GMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCK---------------QPIDLSPGDLLYYGG 1687
            ...::.:::||..:..|.     .|....:||...               :.:||:...:::.|.
Human   969 QCREILKYVNEAVKQTEN-----RHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGP 1028

  Fly  1688 VEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLI 1752
            :.|....|      |.|:||.:  :.:..:|.|.|:   .:|.|:...||.|....:  ..|...
Human  1029 LTWRISKD------KTLDLHVL--LLEDLLVLLQKQ---DEKLLLKCHSKTAVGSSD--SKQTFS 1080

  Fly  1753 PVTE---VQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRES 1814
            ||.:   |.:| |.|.|..:.|    |...|:|  ...::|.|...|:..:|.:::.:.:.:|.:
Human  1081 PVLKLNAVLIR-SVATDKRAFF----IICTSKL--GPPQIYELVALTSSDKNTWMELLEEAVRNA 1138

  Fly  1815 VRNMSIPMKNFGGSSGSVSGHSSQGMGSMGY----PGNSQTLERPKQQ-----------ITIVHG 1864
            .|:                    .|...|..    ||..:    |.||           ..:.||
Human  1139 TRH--------------------PGAAPMPVHPPPPGPRE----PAQQGPTPSRVELDDSDVFHG 1179

  Fly  1865 SHTLGKPKKKSGSQRHSAGN----IDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRG 1925
            .....:....:|||:...|.    ::.....||.|.::|    ||:...|....|:.   .|.|.
Human  1180 EPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEEL----GVLPCPSTSLDGEN---RGIRT 1237

  Fly  1926 RS-----------------KTVGDVTE----ITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHP 1969
            |:                 ..:.||..    |..|....|..:.|..|:.:..:.       |.|
Human  1238 RNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLT-------PTP 1295

  Fly  1970 H-----PHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPN----- 2024
            .     .||.:|..|....|.....::.:    .|.:.|..|....|....:....||.|     
Human  1296 SVISVTSHPWDPGSPGQAPPGGEGDNTQL----AGLEGERPEQEDMGLCSLEHLPPRTRNSGIWE 1356

  Fly  2025 ------HLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQ 2083
                  :|....:||.:.|.    .::::.:....|.....:.:.|:..|...|:|..::     
Human  1357 SPELDRNLAEDASSTEAAGG----YKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTK----- 1412

  Fly  2084 VAASFNLSLGSSGSLF----ASDARDNQT------------------QSRTQSQIHSLHPSPRQS 2126
                      ::|:.|    .|...|:.|                  |:..|.|:...:..||: 
Human  1413 ----------ATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRR- 1466

  Fly  2127 PRQSPRQSPKQDIEVI-EIFESEAERLAASQQVAVVHQH--PSDQARESGHKQRRDRDRNPT--- 2185
            |.:||.....:|:.:| ...|....:|...:.:.:.|:.  .|.....||       ...|.   
Human  1467 PSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSG-------GTTPVGSF 1524

  Fly  2186 ETDATARFMDKHLSDLEQENLTD--------GTCDIVAYMESLREKAFDPQDLAEDTGDHQQNDS 2242
            .|:| ||:.|..||...:|.|..        |.|               |:|.::...:....|:
Human  1525 HTEA-ARWTDGSLSPPAKEPLASDSRNSHELGPC---------------PEDGSDAPLEDSTADA 1573

  Fly  2243 SLSPEP 2248
            :.||.|
Human  1574 AASPGP 1579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 19/124 (15%)
PH 873..974 CDD:278594 15/100 (15%)
TIAM1_RBD 1141..1219 CDD:176413 11/86 (13%)
PDZ_signaling 1221..1308 CDD:238492 17/92 (18%)
RhoGEF 1456..1647 CDD:238091 42/210 (20%)
PH2_Tiam1_2 1650..1823 CDD:269957 39/190 (21%)
PH 1693..1812 CDD:278594 29/121 (24%)
ARHGEF11XP_006711722.1 PDZ_signaling 62..136 CDD:238492 7/73 (10%)
DegQ <77..155 CDD:223343 11/77 (14%)
RGS_PDZRhoGEF 346..490 CDD:188707 36/195 (18%)
RhoGEF 795..979 CDD:279015 42/208 (20%)
PH_PRG 996..1138 CDD:275426 34/161 (21%)
PH <1056..1136 CDD:278594 21/91 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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