DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and ARHGEF10

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_024303103.1 Gene:ARHGEF10 / 9639 HGNCID:14103 Length:1373 Species:Homo sapiens


Alignment Length:1163 Identity:218/1163 - (18%)
Similarity:365/1163 - (31%) Gaps:364/1163 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1359 NGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAE 1423
            :||...|....|......||:...::.||                   ..|:|..|.:||..   
Human   359 DGTKDGLERTRAAVKRGRSFIRTKSLIAQ-------------------DHRSSLEEEQNLFI--- 401

  Fly  1424 QETRKSSPTGSVTSSVSTTALTPSRQ-LTDAEKLRKVVM-ELVDTERTYVKHLNNLLEHYLEPMK 1486
                      .|........|||..: |:..:.:|:.:: .:||:|:.||..|..:||.|.:|:.
Human   402 ----------DVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLS 456

  Fly  1487 --RETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFA---IGSA 1546
              ....||..::..:|..:.||:.....|...|...:.   :::..|..|......|:   :..|
Human   457 EMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVS---EWDSVEMIGDVFVASFSKSMVLDA 518

  Fly  1547 FLYYVNHFK----LYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQR 1607
            :..|||:|.    :....||:             ..|..|||..........:||.|.::|||||
Human   519 YSEYVNNFSTAVAVLKKTCAT-------------KPAFLEFLKQEQEASPDRTTLYSLMMKPIQR 570

  Fly  1608 ILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQR--------------IHEEY-- 1656
            ..::.||||.|...|.....:.:.|..||..:|.:||.:||.:|              |:|.|  
Human   571 FPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLN 635

  Fly  1657 ------------------------GAIF--------------------------DHLFRQHQKSC 1671
                                    |.|.                          ..:....:...
Human   636 KLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLL 700

  Fly  1672 KQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELH-----AMCFVFKSAVVFLCKERLRQK--- 1728
            |..:.|...|.:.||.      |...|:..:.|.:|     |:....|...|::...:|.|.   
Human   701 KWSVPLGHVDAIEYGS------SAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQN 759

  Fly  1729 -----------KKLMGVSSKNATNEVEIIRY------QVLIPVTEVQVRASSAKDMDSHFLWELI 1776
                       .:|:|....|..|..:.:.:      |.||...|.::||:           :..
Human   760 LLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAA-----------DCC 813

  Fly  1777 HLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMG 1841
            .::.||..:.:|     :....|..|...|....|:||..| |:.|       ..::......||
Human   814 RIQLQLPGKQDK-----SGRPTFFTAVFNTFTPAIKESWVN-SLQM-------AKLALEEENHMG 865

  Fly  1842 SMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYD---NLSGSQEADDLPPSV 1903
            ......:...:::.|..:.:.|      .|...:..|........|:   .|:...:.|....:.
Human   866 WFCVEDDGNHIKKEKHPLLVGH------MPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAH 924

  Fly  1904 GVVHYAS-GHTHGQQMQPAGFRGRSKTVGDV----TEITCSSPEPHQQQQQQQQQQQQLMQQGHA 1963
            |.:...| .|..| |:....|:..:..|.:.    :.|.|....|.::::::...          
Human   925 GFLWIGSCTHQMG-QIAIVSFQNSTPKVIECFNVESRILCMLYVPVEEKRREPGA---------- 978

  Fly  1964 HAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGE---EDSQQGTIRPKATLGRTPNH 2025
                     |.:|..|.:|       :||:..|..||: ||.   ..|.||:.:.:.....||..
Human   979 ---------PPDPETPAVR-------ASDVPTICVGTE-EGSISIYKSSQGSKKVRLQHFFTPEK 1026

  Fly  2026 ---LTLSTTST-----LSVGSTGSQARLIQSSHPPASY--QPVLMKDLGKPSPDESELESESEVH 2080
               ::|:.||.     |..|:..|.||.     |..|:  :|..:..|| ..|..|.|..|..:.
Human  1027 STVMSLACTSQSLYAGLVNGAVASYARA-----PDGSWDSEPQKVIKLG-VLPVRSLLMMEDTLW 1085

  Fly  2081 AAQVAASFNLSL-----------------------------------GSSGSLFASDARDNQTQS 2110
            ||.....|.:|:                                   ||:..||.::...:....
Human  1086 AASGGQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDI 1150

  Fly  2111 RTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEA-ERLAASQQVAVVHQHPSDQARESGH 2174
            ...:.:|::.|.             .|.:.|..:..... ..:..|..|.|....|..|....  
Human  1151 NIATPVHNMLPG-------------HQRLSVTSLLVCHGLLMVGTSLGVLVALPVPRLQGIPK-- 1200

  Fly  2175 KQRRDRDRNPTETDATARFM---DKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTGD 2236
                          .|.|.|   ..|.|.::          .:....:|.||            |
Human  1201 --------------VTGRGMVSYHAHNSPVK----------FIVLATALHEK------------D 1229

  Fly  2237 HQQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATES-------------DSTGNTTGPSERSG- 2287
            ..::..||:|.|:...|:.:..:      ||..|..|             ||.|:.|..|:.|. 
Human  1230 KDKSRDSLAPGPEPQDEDQKDAL------PSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSS 1288

  Fly  2288 -------------DETEEEATTSSLASHIVVIDKKVDKIFKAKSPERPASTKVKGGRR 2332
                         :...|::|...|....|.:..|..:..|||:.........:|.||
Human  1289 SGSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRR 1346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 52/200 (26%)
PH2_Tiam1_2 1650..1823 CDD:269957 41/263 (16%)
PH 1693..1812 CDD:278594 25/143 (17%)
ARHGEF10XP_024303103.1 PTZ00441 <27..278 CDD:240420
RhoGEF 426..610 CDD:238091 52/199 (26%)
PH-like 643..>707 CDD:327399 3/63 (5%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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