DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and KALRN

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_006713873.1 Gene:KALRN / 8997 HGNCID:4814 Length:2988 Species:Homo sapiens


Alignment Length:2327 Identity:432/2327 - (18%)
Similarity:750/2327 - (32%) Gaps:763/2327 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   572 GSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMENLEFAESLPGSNQRSPYPLRRPN 636
            |.|:....||..:|...||             :|.:.....|..:..::|....||   ||...|
Human   444 GLPSEMQDLELAIHHHQTL-------------YEQVTQAYTEVSQDGKALLDVLQR---PLSPGN 492

  Fly   637 AKSSTLPL----PPHRPLSTIRD-KERDRDRDGYYSDRNELIRER--------ERERDRGYLSDH 688
            ::|.|...    ..|:.|..:.: ....|..:..:..|...:.:|        :.::...::.:|
Human   493 SESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENH 557

  Fly   689 NSSFSNSRCASCIGES---ARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLP 750
            ..:|.:....  :|:|   |||...||.|......:|..:........:|:..:| :..|     
Human   558 GEAFLSKHTG--VGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTG-ECDP----- 614

  Fly   751 SLRQDSSLNDSGYKSARADSLEQR-AEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLT 814
                     :..||:||  .||.| .:|:|:...|...|                  |..:.:.|
Human   615 ---------EEIYKAAR--HLEVRIQDFVRRVEQRKLLL------------------DMSVSFHT 650

  Fly   815 SSE-----ISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWL 874
            .::     :.|..:..|....:|..|....:...::.:.|.|..::.|    |.|.|        
Human   651 HTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLN----VIKEG-------- 703

  Fly   875 LRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKH---LIIVDGAIMQPIPEHP 936
               :..|:..|           .....|..|.::|:.........|   :..::..:.|......
Human   704 ---EDLIQQLR-----------SAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQV 754

  Fly   937 KRDYIFCLSTAFGDAYL-------FQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHL-LQEE 993
            :.:.:|.......|.:|       :......||:.|...:        .|......|..| |.|:
Human   755 QMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDL--------LRQMNDFNTEDLTLAEQ 811

  Fly   994 IFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQI----------------LQWEENLERLH 1042
              ||::  .::.||. |..:...|:...:..||..|::                .|.:|.||.||
Human   812 --RLQR--HTERKLA-MNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQELLEFLH 871

  Fly  1043 CEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAG 1107
            .:|..|.  :.:.|:.:.......|.|:....|..|..:             ....|:||..|. 
Human   872 EKQHELE--LNAEQTHKRLEQCLQLRHLQAEVKQVLGWI-------------RNGESMLNASLV- 920

  Fly  1108 RGATKRRPPMLSRSNSGSSRRSMQMNSRDEP--------------EKTFKVAMPDNAYSTVYLR- 1157
                          |:.|...:.|:....|.              :||.:.|:.....:.|.|: 
Human   921 --------------NASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQA 971

  Fly  1158 ---DAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFV---------------------- 1197
               ||.::.|     ||.:   ...|:.::..:  |||....|                      
Human   972 GHYDADAIRE-----CAEK---VALHWQQLMLK--MEDRLKLVNASVAFYKTSEQVCSVLESLEQ 1026

  Fly  1198 PHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCC-YVSR-- 1259
            .:|.|  |::....:.:....:|.:.:.|....|||...|.....|   |.|..|:.. |:.|  
Human  1027 EYRRD--EDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTL---ARRNAEVFLKYIHRNN 1086

  Fly  1260 VEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEE-----------------QSLSMMM 1307
            |...|||.|.   :|.|..|  .||:|:|        ||.|                 |...:..
Human  1087 VSMPSVASHT---RGPEQQV--KAILSEL--------LQRENRVLHFWTLKKRRLDQCQQYVVFE 1138

  Fly  1308 RSSR------------------------TEPPDLV---GIMRVTDDMIDSLVCPPPPTDPPVMSE 1345
            ||::                        .|..:|:   |..||                |...::
Human  1139 RSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRV----------------PAKQTK 1187

  Fly  1346 EMITGLIVPAPGWNGTSK-DLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSR 1409
            |.:..||..|..:  ..| .:::.|......|  ||.......|.:|.....:...|||....::
Human  1188 EKVKLLIQLADSF--VEKGHIHATEIRKWVTT--VDKHYRDFSLRMGKYRYSLEKALGVNTEDNK 1248

  Fly  1410 TSSFEI--------ENLLKTA----EQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVME 1462
            ....:|        |..|:.|    .:|.|||                       |.|...::.|
Human  1249 DLELDIIPASLSDREVKLRDANHEVNEEKRKS-----------------------ARKKEFIMAE 1290

  Fly  1463 LVDTERTYVKHLNNLLEHYLEPM-----KRETFLSNAEINALFGNIHEIVTFQRQ-FLQNLEESL 1521
            |:.||:.||:.|:..||.||..|     :....:.|.| :.:||||.||..|... ||:.||:..
Human  1291 LLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKE-HIIFGNIQEIYDFHNNIFLKELEKYE 1354

  Fly  1522 DLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAA 1586
            .|..|                :|..|:.:.:.|::|.::|.:...:.:::..:.|.. ..|.   
Human  1355 QLPED----------------VGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTF-FDEI--- 1399

  Fly  1587 RNPKQQH--SSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEM 1649
               :|:|  ::::.||||||:|||.||.|||:::....:....|   |.:.|:.|..|.:..|:.
Human  1400 ---QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE---LKDGLEVMLSVPKKANDA 1458

  Fly  1650 QRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVE-WLNISDFLGKIKKGLELHAMCFVF 1713
            ..:....|  ||           :.:|:. |:|:.....: |    |....|:||.|.|  .|:|
Human  1459 MHVSMLEG--FD-----------ENLDVQ-GELILQDAFQVW----DPKSLIRKGRERH--LFLF 1503

  Fly  1714 KSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHL 1778
            :.::||        .|::     |:::...:.: |:..:..:|:.|......|.....||     
Human  1504 EISLVF--------SKEI-----KDSSGHTKYV-YKNKLLTSELGVTEHVEGDPCKFALW----- 1549

  Fly  1779 RSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNM-----------SIPMKNFGGSS-GS 1831
             |.....|:...||..|..:.:..::|.||::|:|.:.::           ..|.|....|. ..
Human  1550 -SGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1613

  Fly  1832 VSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEA 1896
            |....|||.||                          .:|...|.:.|.|...:|.|.|||..|.
Human  1614 VEDIDSQGDGS--------------------------SQPDTISIASRTSQNTVDSDKLSGGCEL 1652

  Fly  1897 DDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEI---------------TCSSPE---- 1942
                 :|.:..:::||:....:|          ||...|:               |..||.    
Human  1653 -----TVVLQDFSAGHSSELTIQ----------VGQTVELLERPSERPGWCLVRTTERSPPLEGL 1702

  Fly  1943 --------PHQQQQQQQQQQQQLMQQGHAH----------------AHP-----HPHPHPREPP- 1977
                    .|.:...:......|::..::|                |.|     |..|.|:... 
Human  1703 VPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTN 1767

  Fly  1978 ------PPPIRQPHLHHHSSDIER----------IDPGTKSEGEEDSQQG-TIRPKATLG---RT 2022
                  ..|:|:.:......:|::          .|.|:...|:|.:.|| :...|:..|   ..
Human  1768 TLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDE 1832

  Fly  2023 PNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDL-GKPSPDE------------SELE 2074
            |:                      :.||.|.   |..||.. ..|:.||            :|:.
Human  1833 PD----------------------EESHTPL---PPPMKIFDNDPTQDEMSSSLLAARQASTEVP 1872

  Fly  2075 SESE-VHAAQVAASFNLSLGSSGSLFASDARD-----NQTQSRTQSQIHSLHPSPRQSPRQSPR- 2132
            :.:: |:|.:......|||  .||.:....:|     |:..:         .|:|.::|.:..: 
Human  1873 TAADLVNAIEKLVKNKLSL--EGSSYRGSLKDPAGCLNEGMA---------PPTPPKNPEEEQKA 1926

  Fly  2133 --------------QSPKQDIE----VIEIFESEAERLAASQQV--------AVVHQHPSDQARE 2171
                          |:.|..::    |:|.|....|.....:.:        ..:||      ..
Human  1927 KALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQ------IY 1985

  Fly  2172 SGHK-----------QRRDR-------------------DRNPTETDATARFMDKHLSDLEQE-- 2204
            ..||           |.:||                   ...|......|.: |.:..:::||  
Human  1986 DWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DAYFEEVKQEIN 2049

  Fly  2205 ---NLTDGTC--------------DIVAYMESLREKAFDPQDLAE-------------DTGDHQQ 2239
               .|:|...              |.:.|.|....:..|.:...|             :.|..|.
Human  2050 QRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQG 2114

  Fly  2240 NDSSLSPEPQTIVENTQQTVVVDIESPSRPATE-----------SDSTGNTTGPSERSGDETEEE 2293
            .:.:|:.:.:.:.::|...:.:|....||....           |:..        |.|..|...
Human  2115 FEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELL--------RKGSLTPGY 2171

  Fly  2294 ATTSSLASHIVVIDKKVDK------IFKAKSPERPASTKVKGGRRQIYISP--DRCKSQG----- 2345
            ....|:..:.:|:::.||.      :...::.||..........:|.::..  ...::|.     
Human  2172 MFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNA 2236

  Fly  2346 -SSPVRIIKIKSPRTSLSDQGKRLSVCSSRDNSQDRLSAGRRTPSPRRSSEGGGI--LK-HTTGP 2406
             .||:...:.:.....:..|..||...|.|..|.  :.||...| |:.||....:  || .|:..
Human  2237 LQSPIEYQRKERSTAVMRSQPARLPQASPRPYSS--VPAGSEKP-PKGSSYNPPLPPLKISTSNG 2298

  Fly  2407 DPGI--LKPPSSPAKSKSPD----------------------RSCLKKGGPSHVCSVETLSPRVS 2447
            .||.  .:|......||..|                      ..|:.:|....|.:|...:..:.
Human  2299 SPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLV 2363

  Fly  2448 PRGSMDHLSPDRGMTSSSCLRHSPRSSFDSHGESDHNLDVPHGSRKRSMSAH 2499
            .:.:.||.....|....|.|  :|.:...:...||       ||.|:|.|.|
Human  2364 YQPASDHSPAAEGWVPGSIL--APLTKATAAESSD-------GSIKKSCSWH 2406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 17/134 (13%)
PH 873..974 CDD:278594 13/110 (12%)
TIAM1_RBD 1141..1219 CDD:176413 17/103 (17%)
PDZ_signaling 1221..1308 CDD:238492 27/106 (25%)
RhoGEF 1456..1647 CDD:238091 55/198 (28%)
PH2_Tiam1_2 1650..1823 CDD:269957 36/184 (20%)
PH 1693..1812 CDD:278594 26/118 (22%)
KALRNXP_006713873.1 SEC14 41..179 CDD:214706
SPEC 192..412 CDD:238103
SPEC 313..538 CDD:238103 21/109 (19%)
SPEC 539..768 CDD:238103 45/291 (15%)
SPEC 893..1131 CDD:238103 57/293 (19%)
SPEC <1101..1240 CDD:295325 28/168 (17%)
RhoGEF 1286..1456 CDD:238091 55/196 (28%)
PH1_Kalirin_Trio_like 1463..1585 CDD:270060 35/161 (22%)
PH 1496..1581 CDD:278594 22/106 (21%)
SH3_Kalirin_1 1651..1710 CDD:212786 11/73 (15%)
SH3-RhoG_link 1708..1934 CDD:293215 42/261 (16%)
RhoGEF 1935..2105 CDD:279015 25/176 (14%)
PH2_Kalirin_Trio_p63RhoGEF 2109..2243 CDD:270061 21/141 (15%)
PH 2142..2228 CDD:278594 13/93 (14%)
SH3_Kalirin_2 2327..2385 CDD:212787 9/59 (15%)
I-set 2473..2567 CDD:254352
Ig 2490..2564 CDD:143165
FN3 2571..2662 CDD:238020
S_TKc 2686..2940 CDD:214567
STKc_Kalirin_C 2692..2939 CDD:271017
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.