DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and ARHGEF7

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001340975.1 Gene:ARHGEF7 / 8874 HGNCID:15607 Length:862 Species:Homo sapiens


Alignment Length:922 Identity:179/922 - (19%)
Similarity:301/922 - (32%) Gaps:361/922 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1405 KPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERT 1469
            ||.|..|.             |.||.|.|     ..|||:..|       ....|:..:::||..
Human   225 KPVSPKSG-------------TLKSPPKG-----FDTTAINKS-------YYNVVLQNILETENE 264

  Fly  1470 YVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCG 1534
            |.|.|..:|..||.|::....||:|.|:.|.||:.||.:||:..:|:|||             |.
Human   265 YSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEE-------------CT 316

  Fly  1535 QFRNVLFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLE 1598
            :.......:|..||..:...| ||.::||:|..|..||  .|.:..|.||:..:.........|.
Human   317 KLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVL--TEHSEELGEFMETKGASSPGILVLT 379

  Fly  1599 SYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHL 1663
            :.|.||..|:.|||.||:                               |::|..|:|     |.
Human   380 TGLSKPFMRLDKYPTLLK-------------------------------ELERHMEDY-----HT 408

  Fly  1664 FRQH-QKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQ 1727
            .||. |||                          :...|   .|.|.|            :.:|:
Human   409 DRQDIQKS--------------------------MAAFK---NLSAQC------------QEVRK 432

  Fly  1728 KKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQL------QRRS 1786
            :|:|          |::|:        ||. :|.....|:.:  |..:.::...|      :.::
Human   433 RKEL----------ELQIL--------TEA-IRNWEGDDIKT--LGNVTYMSQVLIQCAGSEEKN 476

  Fly  1787 EKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQT 1851
            |:..:|      |.|..|..                    .:|..:||...||            
Human   477 ERYLLL------FPNVLLML--------------------SASPRMSGFIYQG------------ 503

  Fly  1852 LERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQ 1916
             :.|...:||.          |...|:.|                                    
Human   504 -KLPTTGMTIT----------KLEDSENH------------------------------------ 521

  Fly  1917 QMQPAGFRGRSKTVGDVTE---ITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPP 1978
                   |...:..|.:.|   ::|::.:..|:..:..|:|.::...|:....||..|....|..
Human   522 -------RNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH 579

  Fly  1979 PPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPK-ATLGRTPNHLTLSTTSTLSVGSTGSQ 2042
            |                :.|.:|   ..||:...:.|. .||....:|.|..|  |::.|..   
Human   580 P----------------VTPSSK---HADSKPAPLTPAYHTLPHPSHHGTPHT--TINWGPL--- 620

  Fly  2043 ARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQ 2107
                   .||.:.:|..:..| :|:|                      .|..|.:|...:  |..
Human   621 -------EPPKTPKPWSLSCL-RPAP----------------------PLRPSAALCYKE--DLS 653

  Fly  2108 TQSRTQSQIHSLHPSPRQSPRQSP-------RQSP---KQDIEVIEIFESEAERLAASQQVAVVH 2162
            ...:|..::     .|::.|.:.|       |:|.   ::|.:::::.|:..             
Human   654 KSPKTMKKL-----LPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYC------------- 700

  Fly  2163 QHPSDQARESGHKQRRDRDRNPTETDATARFMDKH-LSDLEQENLTDGTCDIVAYMESLREKAFD 2226
                     :..|.|:..:.....||    .|..| |:|.:|.:|     |.:....||  ...:
Human   701 ---------TSAKTRQTLNSTWQGTD----LMHNHVLADDDQPSL-----DSLGRRSSL--SRLE 745

  Fly  2227 PQDLAEDTG--------DHQQNDSSLSPE---PQTIVENTQQTVVVDIESPSRPATESDSTGNTT 2280
            |.||:||:.        .::...:|.|.:   ||.::...::.:|.:.:|..:...|..|..:|.
Human   746 PSDLSEDSDYDSIWTAHSYRMGSTSRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTV 810

  Fly  2281 GPSERSGDETEE 2292
            ...:   ||.:|
Human   811 YALK---DEVQE 819

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 52/191 (27%)
PH2_Tiam1_2 1650..1823 CDD:269957 29/179 (16%)
PH 1693..1812 CDD:278594 20/124 (16%)
ARHGEF7NP_001340975.1 CH 21..107 CDD:237981
RhoGEF67_u1 117..163 CDD:318756
SH3_betaPIX 167..220 CDD:212994
RhoGEF 251..428 CDD:238091 66/268 (25%)
PH_Cool_Pix 459..557 CDD:269932 24/189 (13%)
Atrophin-1 <562..>643 CDD:331285 25/134 (19%)
RhoGEF67_u2 613..711 CDD:318755 23/161 (14%)
betaPIX_CC 773..859 CDD:318676 10/50 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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