DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and ARHGEF39

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_011516359.1	Gene:	ARHGEF39 / 84904	HGNCID:	25909	Length:	351	Species:	Homo sapiens

Alignment Length:	267	Identity:	61/267 - (22%)
Similarity:	110/267 - (41%)	Gaps:	38/267 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1462 ELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPD 1526
            ||::|||.|.:.|..:..::|..:|.:..|...|..||||:...|....::.|..||..
Human    29 ELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLEGG------ 87

  Fly  1527 FNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPN-EGNHALQEFLAARNPK 1590
                  |.         |.....:..|.:||:.|.|:..::|..|... :.|...:.|:..:..:
Human    88 ------CW---------GQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEGR 137

  Fly  1591 QQHSS-TLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEM-QRIH 1653
            .:... .|:..|..|:||:.:|..|:..:...|...:.:|..|..|.:.:.:.|:.::.: |:..
Human   138 PEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQKQK 202

  Fly  1654 EEYGAIFDHLFR-QHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAV 1717
            .:     .||.| |...|.:|...|:.|......|  ||.:....|:.:.     .|.|:| :.|
Human   203 ND-----QHLRRVQALLSGRQAKGLTSGRWFLRQG--WLLVVPPHGEPRP-----RMFFLF-TDV 254

  Fly  1718 VFLCKER 1724
            :.:.|.|
Human   255 LLMAKPR 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	42/186 (23%)
		PH2_Tiam1_2	1650..1823	CDD:269957	19/76 (25%)
		PH	1693..1812	CDD:278594	7/32 (22%)
ARHGEF39	XP_011516359.1	RhoGEF	27..195	CDD:295373	42/186 (23%)
ARHGEF39	XP_011516359.1	PH-like	225..>269	CDD:302622	11/45 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910