DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and PSD2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_011535998.1	Gene:	PSD2 / 84249	HGNCID:	19092	Length:	791	Species:	Homo sapiens

Alignment Length:	972	Identity:	193/972 - (19%)
Similarity:	315/972 - (32%)	Gaps:	333/972 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 DGQQQVGSGKVVSAVSSTSLYDNVASGGPGT-NQGADTLPRQMKGGQQDRQDVANSGVNTNTPGV 287
            :.|:|.|..:.|:|:....|...|...|..| :.|.:  |.:..|   .|..:|:.|:|
Human     7 ESQEQPGQAEAVAAMEEDKLLSAVPEEGDATRDPGPE--PEEEPG---VRNGMASEGLN------ 60

  Fly   288 IVTGVGNVGSDMCGQNHV--GSQVGNDDP------AACQMDMDLSKSEGTQAGGGLH-------- 336
                     |.:|...|.  |:....::|      |...:.:.||.:.|...|..|:
Human    61 ---------SSLCSPGHERRGTPADTEEPTKDPDVAFHGLSLGLSLTNGLALGPDLNILEDSAES 116

  Fly   337 --QSVGTCTSSSKGTGTRNKDF----------GDDMTRDAHSHDMHQHNVINNNTRRKTKSTEDM 389
              ...|........:.:...|.          |:...||..|....:  ::.:...|.|:.:...
Human   117 RPWRAGVLAEGDNASRSLYPDAEDPQLGLDGPGEPDVRDGFSATFEK--ILESELLRGTQYSSLD 179

  Fly   390 NVDTSTLKRMLKPMPSTESPVT---------SPEMGRRRYNYYNANAAQTLGHPPHMHQHGMAMG 445
            ::|..:|........|.|:|:|         |||.|.                       |:.:|
Human   180 SLDGLSLTDESDSCVSFEAPLTPLIQQRARDSPEPGA-----------------------GLGIG 221

  Fly   446 -------MGGGGGGGHHIMNNNTMG---RASSQSSRFSG--SRSS--------HEIGRGYPPRNL 490
                   ||..||.|.       :|   |.|..|||...  ||.|        ||.|...|..:
Human   222 DMAFEGDMGAAGGDGE-------LGSPLRRSISSSRSENVLSRLSLMAMPNGFHEDGPQGPGGD- 278

  Fly   491 YLELERERSCIEGSPPSDNVMFDNQCYATTPSSSNGNSDQDQSYGQQQSSGQHPQQQ-------Q 548
                       |.....|.....|.  |:.||..:|.||.|...  ..|.|..|...       |
Human   279 -----------EDDDEEDTDKLLNS--ASDPSLKDGLSDSDSEL--SSSEGLEPGSADPLANGCQ 328

  Fly   549 GPPQ---RSSRHQHHHQ--QAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEAL- 607
            |..:   |.:|..:|.:  |..:|....|.             .|..::.:..|..|...|..|
Human   329 GVSEAAHRLARRLYHLEGFQRCDVARQLGK-------------NNEFSRLVAGEYLSFFDFSGLT 380

  Fly   608 LSQSMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNEL 672
            |..::.....|..|.|..|
Human   381 LDGALRTFLKAFPLMGETQ---------------------------------------------- 399

  Fly   673 IRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTI--------GSGSGH 729
                ||||    :..|   ||...| .|..:.:.::     ||..:.:..:        |...|.
Human   400 ----ERER----VLTH---FSRRYC-QCNPDDSTSE-----DGIHTLTCALMLLNTDLHGHNIGK 447

  Fly   730 GMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRESR 794
            .|..||.                            .|..|.|....:|.: |.|::.|.|.:..:
Human   448 KMSCQQF----------------------------IANLDQLNDGQDFAK-DLLKTLYNSIKNEK 483

  Fly   795 YGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCT 859
            .    :.:|:..:.|.   :.||:.||...:.|..|:...||    .:|:.......:|:::
Human   484 L----EWAIDEDELRK---SLSELVDDKFGTGTKKVTRILDG----GNPFLDVPQALSATTY--- 534

  Fly   860 GAVRKAGFLSVKKWLLRKKH-QIELAR----KRGWKGYWVCLKGTTLLFYPCDSREGRSV-EAAP 918
                |.|.|:      ||.| .::..|    :||||.::..||||.|.....:.|..::: |...
Human   535 ----KHGVLT------RKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDL 589

  Fly   919 KHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACA--------A 975
            |:.|.|..|:.....::.|:..:..|.||....:|||||.:.|:.:|:..|:...|        |
Human   590 KNAIRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPA 654

  Fly   976 A------FARHRGKTGTLHLLQEEIFR--------------------LEKAIESDHKLKHMAELQ 1014
            |      |.|....:.|..|.|||..|                    :|:.|:|....::  .|:
Human   655 AVSSMKKFCRPLLPSCTTRLCQEEQLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEY--RLK 717

  Fly  1015 QSVVTDQETRHQIQTQILQWE-----ENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVS 1071
            :..:|.:::|::....:|..:     ::|||:...       :|:|:..:   |....||.|
Human   718 EHYLTFEKSRYETYIHLLAMKIKVGSDDLERIEAR-------LATLEGDD---PSLRKTHSS 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	39/144 (27%)
		PH	873..974	CDD:278594	31/106 (29%)
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
PSD2	XP_011535998.1	Sec7	317..484	CDD:238100	43/271 (16%)
		PH_EFA6	530..653	CDD:270107	36/135 (27%)
		PH	550..645	CDD:278594	28/94 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910