DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and PREX2

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_079146.2 Gene:PREX2 / 80243 HGNCID:22950 Length:1606 Species:Homo sapiens


Alignment Length:500 Identity:126/500 - (25%)
Similarity:218/500 - (43%) Gaps:91/500 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  1452 DAEK---LRKVVM-ELVDTERTYVKHLNNLLEHYLEPM------KRETFLSNAEINALFGNIHEI 1506
            |.||   ||..|: ||..|||.||..|..|:..:|..|      |.:..::...:..||.||.:|
Human    16 DLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDI 80

  Fly  1507 VTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVL 1571
            :...::||:.:||.|..||            |....:|:.||::.:.|::|..:|::|.||||:|
Human    81 LAVHKEFLKVVEECLHPEP------------NAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLL 133

  Fly  1572 HPNEGNHALQEFL---AARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLC 1633
            ........::.||   .....::.....||.||:.|||||.||||:|:::...|..:..::..:.
Human   134 LELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVM 198

  Fly  1634 EALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISD--- 1695
            |||:.|:.|..:|||.:|..|:...:.:  ::.|.:                 |.|..||:|   
Human   199 EALQAMKAVCSNINEAKRQMEKLEVLEE--WQSHIE-----------------GWEGSNITDTCT 244

  Fly  1696 ------FLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATN-EVEIIRYQVLIP 1753
                  .|.||..|.....:.|:|.:.:|: ||.:.|:.|     :||.:|: ...:.|.::...
Human   245 EMLMCGVLLKISSGNIQERVFFLFDNLLVY-CKRKHRRLK-----NSKASTDGHRYLFRGRINTE 303

  Fly  1754 VTEVQVRASSAKDMDS--HFL---WELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRE 1813
            |.||:.......|..|  |.:   |: ||     .....|.:|....|.:.::.:.:.|.: .||
Human   304 VMEVENVDDGTADFHSSGHIVVNGWK-IH-----NTAKNKWFVCMAKTPEEKHEWFEAILK-ERE 361

  Fly  1814 SVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQ 1878
            ..:.:.:.|:.......|..|.....|  |...||  .::..|:::|..        ||...||:
Human   362 RRKGLKLGMEQDTWVMISEQGEKLYKM--MCRQGN--LIKDRKRKLTTF--------PKCFLGSE 414

  Fly  1879 RHSAGNIDYDNLSGSQEADDLPPSV---GVVHYASGHTHGQQMQP 1920
             ..:..::...:...:|...|..::   |::|:.   |...|.:|
Human   415 -FVSWLLEIGEIHRPEEGVHLGQALLENGIIHHV---TDKHQFKP 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 62/200 (31%)
PH2_Tiam1_2 1650..1823 CDD:269957 38/187 (20%)
PH 1693..1812 CDD:278594 30/133 (23%)
PREX2NP_079146.2 RhoGEF 27..213 CDD:279015 61/197 (31%)
PH_Collybistin_ASEF 218..364 CDD:269931 37/177 (21%)
PH 248..356 CDD:278594 27/119 (23%)
DEP_1_P-Rex 382..462 CDD:239886 17/89 (19%)
DEP_2_P-Rex 474..566 CDD:239887
PDZ_signaling 595..670 CDD:238492
PDZ_signaling 677..744 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1581..1606
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.