Protein Alignment sif and fgd4b

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: XP_001332264.7
• Gene: fgd4b / 793364
• ZFINID: ZDB-GENE-110421-6
• Length: 775
• Species: Danio rerio
• Alignment Length: 580
• Identity: 110/580 - (18%)
• Similarity: 223/580 - (38%)
• Gaps: 146/580 - (25%)

  Fly  1298 QEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPT---------DPPVMSEEMITGLIV 1353
            |.|.|.|..::       |...::|  ...:.|:...|||.         .|.:.:..:|.|
Zfish    59 QVEDSASSFLK-------DASSVLR--KSAVYSVSAMPPPAVLPKPKFQCPPKISAANVIDG--- 111

  Fly  1354 PAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGG------LGVAKPTSRTSS 1412
                 ..|..| .:.|..:|..::..:.||.:...:....|..|..|      .|..:.:.|.:.
Zfish   112 -----EQTDND-KTRERTTSDQSASSECAASSFSASDQSSGWDVWSGWWSEEVRGQQEESGRGNG 170

  Fly  1413 FEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPS-------RQLTDAEKLRKVVMELVDTERTY 1470
            ..:|   |..||...|..   .:...:......||       ::..:..||.|:..||:.|||.|
Zfish   171 ASVE---KEEEQSRWKQD---GLNEDMENDEDKPSVENDEDQQEQVNKLKLFKISSELLQTERAY 229

  Fly  1471 VKHLNNLLEHYLEPMKRETFLSNAEIN---ALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEH 1532
            |..|:.|.:.:...:..|....:..::   .:|.|:..|.||..|||..     |||...::::.
Zfish   230 VSRLHLLDQVFCVRLTEEALKGSFPVDVVKGIFSNVGSIYTFHSQFLLP-----DLETRMSQWDS 289

  Fly  1533 CGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVL-----HPNEGNHALQEFLAARNPKQQ 1592
            ..:..:||..: :.||      ::|:.:..:...|.::|     ...:.:..:|:.   ::.:..
Zfish   290 KPRVGDVLAQL-APFL------RMYAEYVKNFDSAMELLKLWMERSTQFSAIIQDI---QSQEVC 344

  Fly  1593 HSSTLESYLIKPIQRILKYPLLLQQ-MRNLTDTRADEH-------------VHLCEALKGMEKVA 1643
            .|.||:.::::|:||:.:|.:||:. ::.|.:...|..             .|...|::.|
Zfish   345 GSLTLQHHMLEPVQRVPRYEMLLKDYLKKLPEDDEDRSQAQKSLNIISMAATHSNMAIRKM---- 405

  Fly  1644 EHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKG--LEL 1706
            |::.::..|:|..|                            |..:.:|.|:.|  ||:|  |:|
Zfish   406 ENLKKLMEIYEMLG----------------------------GEEDIVNPSNEL--IKEGQILKL 440

  Fly  1707 HA--------MCFVFKSAVVF------LCKER--LRQKKKLMGVSSKNATNEVEIIRYQVLIPVT 1755
            .|        ..|:|.:.:::      |..:|  :|.:.::.|:.....:||.....:||.....
Zfish   441 AARNTSSMERYLFLFNNMLLYCVPKFSLVGQRFTVRTRVRVEGMKVLETSNEDYPHTFQVSGKER 505

  Fly  1756 EVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESV 1815
            .::::|||.:|.:.   |        ::...|.:.:.......|::|..:...::.:|.:
Zfish   506 TLELQASSQQDKED---W--------IKAFQETIEIFQQKNETFKSACKEATDEVSKEEL 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492	4/9 (44%)
		RhoGEF	1456..1647	CDD:238091	46/212 (22%)
		PH2_Tiam1_2	1650..1823	CDD:269957	32/184 (17%)
		PH	1693..1812	CDD:278594	26/136 (19%)
fgd4b	XP_001332264.7	RhoGEF	221..399	CDD:214619	41/192 (21%)
		PH1_FDG4	431..524	CDD:275434	22/105 (21%)
		FYVE_FGD1_2_4	559..623	CDD:277280
		PH2_FGD1-4	645..748	CDD:270056

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910