DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and plekhg4

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001128280.3 Gene:plekhg4 / 779571 XenbaseID:XB-GENE-5998210 Length:1921 Species:Xenopus tropicalis


Alignment Length:2038 Identity:378/2038 - (18%)
Similarity:648/2038 - (31%) Gaps:670/2038 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   303 NHVGSQVGNDDPAACQMDMDLSKSE----------------GTQAGGGLHQSVGTCTSSSKGTGT 351
            ::|.|:..:......|:...:|.||                |.|. |.|.||:.....|.:.|..
 Frog   233 DYVSSEASSTLDTEFQVKTSMSSSEIEGEYVQLSDISVPRLGPQM-GSLTQSIALNYKSQQKTVA 296

  Fly   352 RNKDFGDDMTRDAHSHDMHQHNVINNNTRRKTKSTEDMNVDTSTLKRMLKPMPSTESPVTSPEMG 416
            :       .|:|      .|:.|:..::|....|.    |.:..:..:....|||::        
 Frog   297 Q-------QTQD------KQNQVVFLDSRTYKTSV----VSSDIMPTLCSLQPSTKA-------- 336

  Fly   417 RRRYNYYNANAAQTLGHPPHMHQH--------GMAMGMGGGGGGGHHIMNNNTMGRASSQSSRFS 473
                         |..|.|...|:        .:|.|             .:...:...|.|.||
 Frog   337 -------------TFSHKPTTQQNIDVQDKIVDLAFG-------------ESISKKHLKQESSFS 375

  Fly   474 GSRSSHEIGRGYPPRNLYLELER-ERSCIEG--SPPSDNVMFDNQCYATTPSSSNGNSDQDQSYG 535
            .....|........:|.:.:.|. ....:.|  |...|.......|  ..||...||.....|: 
 Frog   376 AGSIKHSFVETCITQNNHQKHEDISEITVPGKVSDTGDTDKCTQSC--EQPSLQGGNFSTSLSF- 437

  Fly   536 QQQSSGQH-----------PQQQQGPPQRSSRHQ-----HHHQQAPNVTP--------------- 569
             ||.|..|           ....|.||...||.|     .:.|.:....|               
 Frog   438 -QQESRSHFINGTEDVRVVTDALQEPPAEHSRPQETVSVEYFQSSNKAIPKDLIHYTITDKCDQS 501

  Fly   570 TPGSPTSRLLLEYEMHLRNTL-----AKGMDAESYSLHTFEA----------------------- 606
            .|...|::...|.:....||.     .|..:|.|:...:.|:                       
 Frog   502 LPSMDTTKCQFEEQKSKENTADTEESPKNRNAGSHIYSSAESSAFAVSVLQEGNNVLNLDVCKES 566

  Fly   607 ----------LLSQSMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIRDKERDRD 661
                      |:|:.:||::...:| ...||...|      ||.:     |..:.|:.:.|    
 Frog   567 GEQVDGVNKELVSRDLENMQLQNAL-SVEQREQEP------KSDS-----HGKIYTMLNSE---- 615

  Fly   662 RDGYY--------SDRNELIRERERE--RDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGW 716
            :.|.:        ||:..|..|...|  .|...|:|.||..||.                     
 Frog   616 QVGTHLSMCVLSGSDKVPLTLETLHEVVEDEQDLADFNSVLSNG--------------------- 659

  Fly   717 RSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQ-RAEFIRQ 780
                              ::|.|              :|.|....|....:.:..:| ..|..:|
 Frog   660 ------------------ELPPS--------------EDISKTALGNLKDQEERTDQDPQENCQQ 692

  Fly   781 DSLRSEYLSDRESRYGI---VQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMAS 842
            :..::..||.|.:...:   .|..::|...|.:.||..::               :..|.:|:. 
 Frog   693 NMCQTPALSRRSNAQPLTIMAQDVNLEVLLSEVVYLPGTK---------------DKSGRAVII- 741

  Fly   843 PYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCD 907
               .....||..:.:|..:  :.|.|.:..:.:.:|....|              |.|||   .|
 Frog   742 ---INTRNTAWLNPHCNAS--ELGRLFLYFYSIPRKDCRSL--------------GLTLL---VD 784

  Fly   908 SREGRSVEAAPKHLIIVDGA-----------IMQPIPEHPKRDY--IFCLSTAFGDAYLFQAPCQ 959
            ||....|.|..|...||..|           :.:.:..|.::.:  .|.|.|:....:......|
 Frog   785 SRRCSPVPALFKAFHIVQAAVPSCIHGVLMLVEKDLALHVEKPHGIQFDLLTSTKSLHKHIEASQ 849

  Fly   960 VELE----------NWV----------NSIHSACAAAFARHRGKTGTLHLLQEEIFRL------E 998
            :.||          :||          .:..:|||              .||:.|..|      .
 Frog   850 LPLEFDGLFRYCHKDWVTFRMKLEHLQENCRNACA--------------FLQDAIKNLHIDSLPN 900

  Fly   999 KAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEEN----LERLH----C----EQFRLRCY 1051
            ||.::...|:...||.:.|:.|        |:::|.::.    |.||.    |    |.:|....
 Frog   901 KAEDAKLLLQKFGELMRMVLED--------TRLVQLQKEGGAILARLRKEESCVTLTEDYREAVD 957

  Fly  1052 MASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPP 1116
            :|:....::......|..||......:.     .|..|.||                        
 Frog   958 VAAELYNQVDEGVHSLVKVSNKRIQEME-----LVIEFEAF------------------------ 993

  Fly  1117 MLSRSNSGSSRRSMQMNSRDE--PEKTFKVAMPDNAYSTVYLRDAMSVEEFLASAC--ARRNLNP 1177
                     ..:..::.|..|  .|:..|..........|.|:.....:||...||  .||..:.
 Frog   994 ---------QEQFQEVGSWIEHVGERLLKECNTLEDSLEVLLQTQRQFKEFYVVACEYCRRGQDI 1049

  Fly  1178 MEHFVRVKKRRDMED-----HNYFVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGF 1237
            |:   :::|.:|:..     |...:....:.:|::....|      :..||:| :..||.|.:..
 Frog  1050 MQ---KMEKWQDLSSSETQIHRLKLQRCKEKVEDFWRRLE------ESRYQLE-KSVTLYQFFDK 1104

  Fly  1238 SVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMM----------- 1291
            :.|..|    ||...|..: |..:..|..|....|:|.|...|....:|:...|           
 Frog  1105 AYEWAL----ERMRHLASF-SLDDCSSPEMCLSAIEGLERYKIQHPEISEEKFMEMKELACELKI 1164

  Fly  1292 -------------------YLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDS----LVC 1333
                               .||..|:.......|:...::.|.:..|:.:  .::::|    ...
 Frog  1165 EKATKQWKFAWSKCQEARHVLEKKLEAALRAKSMLSGEQSSPREADGMEQ--KELLESNRNKYFF 1227

  Fly  1334 PPPPTDPPVMSEEMITG-LIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGG-- 1395
            ...|.:.|:...|...| ::...|....|........:.:|.|.|.|.......::::..:.|  
 Frog  1228 QSKPYNSPLCPRERRLGRVLCNRPEIGNTDDHTTRKASPTSDAGSTVTSVFRTRKMSLQSISGED 1292

  Fly  1396 -----VVVGGLGVAKPTSRTSSFEIENLLKTAEQ-------------ETRKSSPTGSVTS----- 1437
                 :.:...|.:.||.....| ...||:.|:.             :.|.|.||....:     
 Frog  1293 LSLDLLHIAPSGSSTPTVTPRPF-TRRLLRKAQSFDLPGSEGPGYGCQRRLSEPTRRGNTGVFIK 1356

  Fly  1438 --SVSTTALT----PSRQLTD----------------------AEKLRKVVMELVDTERTYVKHL 1474
              .||:|.|.    ..||..|                      :.|||.::.|:|.|||.||:.|
 Frog  1357 GLEVSSTELVDRPCSPRQTRDWSAECMYSERRCSVSSSDGRSRSSKLRHIIDEMVTTEREYVRSL 1421

  Fly  1475 NNLLEHYLEPMKRETFLSN--AEINALFGNIHEIVTFQRQ-FLQNLEESLDLEPDFNKFEHCGQF 1536
            ..:.|:|...|:|.....:  .:...:|||:.::..|..| ||:.||...: .|  .:..||   
 Frog  1422 WYISENYFPEMERVDLPQDLRGKRGIIFGNLEKLRDFHSQYFLKELESCCN-HP--LRVSHC--- 1480

  Fly  1537 RNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHA-----LQEFLAARNPKQQHSST 1596
                      ||.:.:.|.:|:.:..:..::..:|    |:|.     .::||..      ....
 Frog  1481 ----------FLRHKDQFGMYALYSKNKPRSDALL----GSHGNIFFKNKQFLLG------DKMD 1525

  Fly  1597 LESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGME----KVAEHINEMQRIHEEYG 1657
            |.|||:|||||:.||.|||:.:           :..||..:..|    :.||.:.:.|..|..  
 Frog  1526 LASYLLKPIQRMSKYALLLKDL-----------IKECEEAQEQELAYLRAAEEMVKFQLRHGN-- 1577

  Fly  1658 AIFDHLFRQHQKSCKQPIDL-SPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLC 1721
               |.|.....:.|  .::| ..|.|     |.....:.:||  :|..:.|.  |:|:..::|  
 Frog  1578 ---DLLAMDAIRDC--DVNLKEQGQL-----VRQDEFTVWLG--RKKCQRHV--FLFEDLILF-- 1626

  Fly  1722 KERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRS 1786
                .:.|::.|        .:::..|:......::.:..:|.   ||...:|:...|    |:|
 Frog  1627 ----SKPKRIEG--------GLDVYIYKRSFKTADIGLTENSG---DSGLRFEIWFRR----RKS 1672

  Fly  1787 EKVYVLSNSTADFRNAFLKTIRQII-RESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQ 1850
            ...::|..|..:.::|:...|.:|: :::.||..|.|               |.|.|||. ||..
 Frog  1673 SDTHILQASNPETKHAWTSDIAKILWQQATRNKEIRM---------------QEMVSMGV-GNKP 1721

  Fly  1851 TLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHG 1915
            .|:.               ||...:.:.|    .:|| .:.|.........:|.:..::..:..|
 Frog  1722 FLDI---------------KPSDAAINNR----AVDY-IMKGRGARTRASIAVSLFDHSDPYKRG 1766

  Fly  1916 QQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPP 1980
            |                 ..|||||     ...........|:...:.|.:              
 Frog  1767 Q-----------------APITCSS-----VSSAGGPSSSSLLGPLNLHTY-------------- 1795

  Fly  1981 IRQPHLHHHSSDIERIDPGTKSEGEE-DSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQAR 2044
            :.|..|....|.....|..:..|.:| :::..:.:|..|...:.:...:|     ..||:||.:.
 Frog  1796 VNQSLLSGVFSTSRPFDTSSCLEEDELENETNSSQPSMTTESSESSQCMS-----GAGSSGSDSG 1855

  Fly  2045 LIQSSHPPASYQPVLMKDLGKPS 2067
            .:  |:.|   |..:.:|.|.||
 Frog  1856 CV--SNIP---QDNVSEDAGSPS 1873

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 29/157 (18%)
PH 873..974 CDD:278594 25/133 (19%)
TIAM1_RBD 1141..1219 CDD:176413 15/84 (18%)
PDZ_signaling 1221..1308 CDD:238492 24/116 (21%)
RhoGEF 1456..1647 CDD:238091 54/202 (27%)
PH2_Tiam1_2 1650..1823 CDD:269957 34/174 (20%)
PH 1693..1812 CDD:278594 22/119 (18%)
plekhg4NP_001128280.3 SEC14 719..857 CDD:238099 33/175 (19%)
SPEC 989..1193 CDD:413338 44/251 (18%)
RhoGEF 1406..1571 CDD:395496 52/201 (26%)
PH_puratrophin-1 1570..1705 CDD:270062 32/171 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.