DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and Arhgef38

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001355681.1 Gene:Arhgef38 / 77669 MGIID:1924919 Length:770 Species:Mus musculus


Alignment Length:608 Identity:130/608 - (21%)
Similarity:232/608 - (38%) Gaps:165/608 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1444 LTPSRQLTDAE---------------KLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSN 1493
            :||..:.:.||               |..|::.||:.|||.|:..|...|...::|: |...:..
Mouse    68 MTPQAECSSAETPTPEDEQQVGRMMAKRAKIIRELIQTERDYLTDLELCLREVVQPL-RSKQIDR 131

  Fly  1494 AEINALFGNIHEIVTFQRQFLQNLEE-SLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFK-L 1556
            .::..||.||..:.....:.|..||| :.|:||             .:..||..||......: :
Mouse   132 LDVEGLFSNIESVHQISAKLLSLLEEATTDVEP-------------AMQVIGEVFLQIKGPLEDI 183

  Fly  1557 YSSFCASHSKAQKVLHPNEGNHALQEFL-----AARNPKQQHSS----TLESYLIKPIQRILKYP 1612
            |..:|..|.:|..||...|....|::.|     :.:|...|...    .:.|.:||||||::|||
Mouse   184 YKIYCYHHDEAHSVLESYEKEEELKQHLSHCLQSLKNIYLQEGKPNLLDMGSLMIKPIQRVMKYP 248

  Fly  1613 LLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQR-------------------------- 1651
            |||.::||.|.....::..|.||...::.:..:|||::|                          
Mouse   249 LLLCELRNSTPPSHPDYRALGEAFAAVKDINVNINELKRRKDLVLKYKKNEEEESLKDKLSKLNI 313

  Fly  1652 --IHEEYGAIFDH---------------------LFRQHQK----------SCKQPI-DLSPGDL 1682
              |.::...:.:|                     |||..:|          ||.|.| :.:|..|
Mouse   314 HSISKKSKRVTNHLKILTRGESQVKDNTFNREEKLFRSLEKTVRLCVKNISSCLQHIEEATPFTL 378

  Fly  1683 LYYGGVEWLNIS--------------------DFLGKIKKGL--ELHAMCFVFKSAVVFLCKERL 1725
              ..|.|...||                    ||..:.::.:  .|.|:..:|..      .::|
Mouse   379 --QSGAELREISYQDGEKNGTEPQDQASKPYQDFAARSQRLILNPLSALLSLFPG------PQKL 435

  Fly  1726 RQKK--KLMGVSS---KNATNEVEIIR--YQVLIP--VTEVQVRASSAKDMDSHFLWELIHLRSQ 1781
            .||:  ||:..:|   ::||.|.::.:  |:.|..  |.|:|....:||.:..:.|...:.|...
Mouse   436 IQKRYDKLLDYNSSLPRSATTESDLAKREYEALNAQLVEELQAFNQAAKTILLNCLCSFVTLLRD 500

  Fly  1782 LQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYP 1846
            |.:.:.:.| .:..|.......:..|:..:.|.|.:::...:|        |....:...|....
Mouse   501 LMQVALQAY-STVKTVPLPVLGISEIQSRVLEEVHSLTFVKEN--------SATFIERKLSFEKK 556

  Fly  1847 GNSQTL-ERPKQ------QITIVHGSHTLGKPKKK-SGSQRHSAGNIDYDNLSGSQEADDLPPS- 1902
            ..:|.| |.|.|      ::...:|:..|.:.|:| :.:|.|....::.:.::..::.|.|..: 
Mouse   557 KPAQILPEVPHQTDAHRSKLLSTYGAEELYRAKRKCNATQEHDINLLEGELVAVLEQKDPLGSTS 621

  Fly  1903 -----VGVVHYASGHTHGQQMQP 1920
                 .|.|   .|:.:...::|
Mouse   622 RWFVDTGCV---KGYVYSSFLKP 641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 56/201 (28%)
PH2_Tiam1_2 1650..1823 CDD:269957 46/263 (17%)
PH 1693..1812 CDD:278594 29/149 (19%)
Arhgef38NP_001355681.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 33..88 4/19 (21%)
RhoGEF 98..283 CDD:306973 55/198 (28%)
BAR_DNMBP 336..510 CDD:153273 39/182 (21%)
SH3 585..641 CDD:354299 10/58 (17%)
SH3_DNMBP_C2 710..766 CDD:213017
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3224
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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